6FS7

Influenza A/California/04/2009 (pH1N1) endonuclease with I38T mutation with bound inhibitor, baloxavir acid (BXA)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0039694	biological_process	viral RNA genome replication
B	0003723	molecular_function	RNA binding
B	0039694	biological_process	viral RNA genome replication
C	0003723	molecular_function	RNA binding
C	0039694	biological_process	viral RNA genome replication
D	0003723	molecular_function	RNA binding
D	0039694	biological_process	viral RNA genome replication
E	0003723	molecular_function	RNA binding
E	0039694	biological_process	viral RNA genome replication
F	0003723	molecular_function	RNA binding
F	0039694	biological_process	viral RNA genome replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue MN A 901

Chain	Residue
A	HIS41
A	ASP108
A	GLU119
A	ILE120
A	E4Z903

---

site_id	AC2
Number of Residues	5
Details	binding site for residue MN A 902

Chain	Residue
A	HOH1051
A	GLU80
A	ASP108
A	E4Z903
A	HOH1011

---

site_id	AC3
Number of Residues	19
Details	binding site for residue E4Z A 903

Chain	Residue
A	MET21
A	TYR24
A	GLU26
A	LYS34
A	ALA37
A	THR38
A	HIS41
A	GLU80
A	ASP108
A	GLU119
A	ILE120
A	LYS134
A	MN901
A	MN902
A	HOH1011
A	HOH1033
A	HOH1044
A	HOH1051
D	GLU198

---

site_id	AC4
Number of Residues	5
Details	binding site for residue MN B 901

Chain	Residue
B	HIS41
B	ASP108
B	GLU119
B	ILE120
B	E4Z903

---

site_id	AC5
Number of Residues	5
Details	binding site for residue MN B 902

Chain	Residue
B	GLU80
B	ASP108
B	E4Z903
B	HOH1024
B	HOH1033

---

site_id	AC6
Number of Residues	16
Details	binding site for residue E4Z B 903

Chain	Residue
B	MET21
B	TYR24
B	GLU26
B	LYS34
B	HIS41
B	GLU80
B	ASP108
B	GLU119
B	ILE120
B	LYS134
B	MN901
B	MN902
B	HOH1024
B	HOH1031
B	HOH1039
C	GLU198

---

site_id	AC7
Number of Residues	5
Details	binding site for residue MN C 901

Chain	Residue
C	HIS41
C	ASP108
C	GLU119
C	ILE120
C	E4Z903

---

site_id	AC8
Number of Residues	5
Details	binding site for residue MN C 902

Chain	Residue
C	GLU80
C	ASP108
C	E4Z903
C	HOH1006
C	HOH1018

---

site_id	AC9
Number of Residues	15
Details	binding site for residue E4Z C 903

Chain	Residue
B	GLU198
C	MET21
C	TYR24
C	GLU26
C	LYS34
C	HIS41
C	GLU80
C	ASP108
C	GLU119
C	ILE120
C	LYS134
C	MN901
C	MN902
C	HOH1006
C	HOH1044

---

site_id	AD1
Number of Residues	5
Details	binding site for residue MN D 901

Chain	Residue
D	HIS41
D	ASP108
D	GLU119
D	ILE120
D	E4Z903

---

site_id	AD2
Number of Residues	5
Details	binding site for residue MN D 902

Chain	Residue
D	GLU80
D	ASP108
D	E4Z903
D	HOH1008
D	HOH1033

---

site_id	AD3
Number of Residues	16
Details	binding site for residue E4Z D 903

Chain	Residue
D	ILE120
D	LYS134
D	MN901
D	MN902
D	HOH1008
D	HOH1037
D	HOH1040
A	GLU198
D	MET21
D	TYR24
D	GLU26
D	LYS34
D	HIS41
D	GLU80
D	ASP108
D	GLU119

---

site_id	AD4
Number of Residues	6
Details	binding site for residue MN E 901

Chain	Residue
E	HIS41
E	ASP108
E	GLU119
E	ILE120
E	MN902
E	E4Z903

---

site_id	AD5
Number of Residues	6
Details	binding site for residue MN E 902

Chain	Residue
E	GLU80
E	ASP108
E	MN901
E	E4Z903
E	HOH1014
E	HOH1029

---

site_id	AD6
Number of Residues	17
Details	binding site for residue E4Z E 903

Chain	Residue
E	MET21
E	TYR24
E	GLU26
E	LYS34
E	HIS41
E	GLU80
E	ASP108
E	GLU119
E	ILE120
E	LYS134
E	MN901
E	MN902
E	HOH1014
E	HOH1020
E	HOH1021
E	HOH1029
F	GLU198

---

site_id	AD7
Number of Residues	6
Details	binding site for residue MN F 901

Chain	Residue
F	HIS41
F	ASP108
F	GLU119
F	ILE120
F	MN902
F	E4Z903

---

site_id	AD8
Number of Residues	6
Details	binding site for residue MN F 902

Chain	Residue
F	GLU80
F	ASP108
F	MN901
F	E4Z903
F	HOH1015
F	HOH1041

---

site_id	AD9
Number of Residues	17
Details	binding site for residue E4Z F 903

Chain	Residue
E	GLU198
F	MET21
F	TYR24
F	GLU26
F	LYS34
F	HIS41
F	GLU80
F	ASP108
F	GLU119
F	ILE120
F	LYS134
F	MN901
F	MN902
F	HOH1015
F	HOH1022
F	HOH1026
F	HOH1041

---