5TJH

hUGDH A136M Substitution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001702	biological_process	gastrulation with mouth forming second
A	0003979	molecular_function	UDP-glucose 6-dehydrogenase activity
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005829	cellular_component	cytosol
A	0006024	biological_process	glycosaminoglycan biosynthetic process
A	0006065	biological_process	UDP-glucuronate biosynthetic process
A	0015012	biological_process	heparan sulfate proteoglycan biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0030206	biological_process	chondroitin sulfate biosynthetic process
A	0034214	biological_process	protein hexamerization
A	0042802	molecular_function	identical protein binding
A	0048666	biological_process	neuron development
A	0051287	molecular_function	NAD binding
A	0070062	cellular_component	extracellular exosome
B	0001702	biological_process	gastrulation with mouth forming second
B	0003979	molecular_function	UDP-glucose 6-dehydrogenase activity
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005829	cellular_component	cytosol
B	0006024	biological_process	glycosaminoglycan biosynthetic process
B	0006065	biological_process	UDP-glucuronate biosynthetic process
B	0015012	biological_process	heparan sulfate proteoglycan biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0030206	biological_process	chondroitin sulfate biosynthetic process
B	0034214	biological_process	protein hexamerization
B	0042802	molecular_function	identical protein binding
B	0048666	biological_process	neuron development
B	0051287	molecular_function	NAD binding
B	0070062	cellular_component	extracellular exosome
C	0001702	biological_process	gastrulation with mouth forming second
C	0003979	molecular_function	UDP-glucose 6-dehydrogenase activity
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005829	cellular_component	cytosol
C	0006024	biological_process	glycosaminoglycan biosynthetic process
C	0006065	biological_process	UDP-glucuronate biosynthetic process
C	0015012	biological_process	heparan sulfate proteoglycan biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0030206	biological_process	chondroitin sulfate biosynthetic process
C	0034214	biological_process	protein hexamerization
C	0042802	molecular_function	identical protein binding
C	0048666	biological_process	neuron development
C	0051287	molecular_function	NAD binding
C	0070062	cellular_component	extracellular exosome
D	0001702	biological_process	gastrulation with mouth forming second
D	0003979	molecular_function	UDP-glucose 6-dehydrogenase activity
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005829	cellular_component	cytosol
D	0006024	biological_process	glycosaminoglycan biosynthetic process
D	0006065	biological_process	UDP-glucuronate biosynthetic process
D	0015012	biological_process	heparan sulfate proteoglycan biosynthetic process
D	0016491	molecular_function	oxidoreductase activity
D	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D	0030206	biological_process	chondroitin sulfate biosynthetic process
D	0034214	biological_process	protein hexamerization
D	0042802	molecular_function	identical protein binding
D	0048666	biological_process	neuron development
D	0051287	molecular_function	NAD binding
D	0070062	cellular_component	extracellular exosome
E	0001702	biological_process	gastrulation with mouth forming second
E	0003979	molecular_function	UDP-glucose 6-dehydrogenase activity
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005829	cellular_component	cytosol
E	0006024	biological_process	glycosaminoglycan biosynthetic process
E	0006065	biological_process	UDP-glucuronate biosynthetic process
E	0015012	biological_process	heparan sulfate proteoglycan biosynthetic process
E	0016491	molecular_function	oxidoreductase activity
E	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
E	0030206	biological_process	chondroitin sulfate biosynthetic process
E	0034214	biological_process	protein hexamerization
E	0042802	molecular_function	identical protein binding
E	0048666	biological_process	neuron development
E	0051287	molecular_function	NAD binding
E	0070062	cellular_component	extracellular exosome
F	0001702	biological_process	gastrulation with mouth forming second
F	0003979	molecular_function	UDP-glucose 6-dehydrogenase activity
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005829	cellular_component	cytosol
F	0006024	biological_process	glycosaminoglycan biosynthetic process
F	0006065	biological_process	UDP-glucuronate biosynthetic process
F	0015012	biological_process	heparan sulfate proteoglycan biosynthetic process
F	0016491	molecular_function	oxidoreductase activity
F	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
F	0030206	biological_process	chondroitin sulfate biosynthetic process
F	0034214	biological_process	protein hexamerization
F	0042802	molecular_function	identical protein binding
F	0048666	biological_process	neuron development
F	0051287	molecular_function	NAD binding
F	0070062	cellular_component	extracellular exosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue POP A 501

Chain	Residue
A	PHE272
A	GLY273
A	PHE277
A	PHE338
A	ARG442
A	HOH656

---

site_id	AC2
Number of Residues	9
Details	binding site for residue POP B 501

Chain	Residue
B	PHE277
B	PHE338
B	LYS339
B	ARG442
B	HOH601
B	HOH603
B	GLY271
B	PHE272
B	GLY273

---

site_id	AC3
Number of Residues	1
Details	binding site for residue CL B 502

Chain	Residue
B	SER316

---

site_id	AC4
Number of Residues	17
Details	binding site for residue UPG C 501

Chain	Residue
C	PHE162
C	LYS220
C	ASN224
C	ILE231
C	PHE265
C	LYS267
C	SER269
C	PHE272
C	GLY273
C	CYS276
C	PHE277
C	PHE338
C	LYS339
C	ARG442
C	HOH621
C	HOH710
D	ARG260

---

site_id	AC5
Number of Residues	8
Details	binding site for residue POP D 501

Chain	Residue
D	GLY271
D	PHE272
D	GLY273
D	PHE277
D	PHE338
D	ARG442
D	HOH602
D	HOH678

---

site_id	AC6
Number of Residues	3
Details	binding site for residue CL D 502

Chain	Residue
D	TRP417
D	ASP418
D	MET419

---

site_id	AC7
Number of Residues	6
Details	binding site for residue POP E 501

Chain	Residue
E	PHE272
E	GLY273
E	PHE338
E	LYS339
E	HOH624
E	HOH667

---

site_id	AC8
Number of Residues	8
Details	binding site for residue POP F 501

Chain	Residue
F	GLY271
F	PHE272
F	GLY273
F	PHE277
F	PHE338
F	HOH601
F	HOH602
F	HOH701

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	ACT_SITE: Proton donor/acceptor => ECO:0000269|PubMed:22123821

Chain	Residue	Details
A	GLU161
E	LYS220
F	GLU161
F	LYS220
A	LYS220
B	GLU161
B	LYS220
C	GLU161
C	LYS220
D	GLU161
D	LYS220
E	GLU161

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	ACT_SITE: Nucleophile => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21984906, ECO:0000269|PubMed:22123821

Chain	Residue	Details
A	CYS276
B	CYS276
C	CYS276
D	CYS276
E	CYS276
F	CYS276

---

site_id	SWS_FT_FI3
Number of Residues	30
Details	BINDING: BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK

Chain	Residue	Details
A	GLY11
B	CYS276
C	GLY11
C	ASP36
C	ARG41
C	VAL89
C	CYS276
D	GLY11
D	ASP36
D	ARG41
D	VAL89
A	ASP36
D	CYS276
E	GLY11
E	ASP36
E	ARG41
E	VAL89
E	CYS276
F	GLY11
F	ASP36
F	ARG41
F	VAL89
A	ARG41
F	CYS276
A	VAL89
A	CYS276
B	GLY11
B	ASP36
B	ARG41
B	VAL89

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445

Chain	Residue	Details
A	SER130
B	SER130
C	SER130
D	SER130
E	SER130
F	SER130

---

site_id	SWS_FT_FI5
Number of Residues	24
Details	BINDING: BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF

Chain	Residue	Details
A	GLU161
C	LYS220
C	LYS267
C	PHE338
D	GLU161
D	LYS220
D	LYS267
D	PHE338
E	GLU161
E	LYS220
E	LYS267
A	LYS220
E	PHE338
F	GLU161
F	LYS220
F	LYS267
F	PHE338
A	LYS267
A	PHE338
B	GLU161
B	LYS220
B	LYS267
B	PHE338
C	GLU161

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:21502315, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4

Chain	Residue	Details
A	GLU165
B	GLU165
C	GLU165
D	GLU165
E	GLU165
F	GLU165

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:23106432, ECO:0000269|PubMed:27966912, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF, ECO:0007744|PDB:5TJH

Chain	Residue	Details
A	ARG260
B	ARG260
C	ARG260
D	ARG260
E	ARG260
F	ARG260

---

site_id	SWS_FT_FI8
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0000269|PubMed:22123821, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK

Chain	Residue	Details
A	ARG346
B	ARG346
C	ARG346
D	ARG346
E	ARG346
F	ARG346

---

site_id	SWS_FT_FI9
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:22123821, ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3KHU, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF

Chain	Residue	Details
A	ARG442
B	ARG442
C	ARG442
D	ARG442
E	ARG442
F	ARG442

---

site_id	SWS_FT_FI10
Number of Residues	6
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS107
B	LYS107
C	LYS107
D	LYS107
E	LYS107
F	LYS107

---

site_id	SWS_FT_FI11
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER476
B	SER476
C	SER476
D	SER476
E	SER476
F	SER476

---