5HZK

Crystal structure of photoinhibitable Intersectin1 containing wildtype LOV2 domain in complex with Cdc42

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
A	0007264	biological_process	small GTPase-mediated signal transduction
B	0005085	molecular_function	guanyl-nucleotide exchange factor activity
B	0035556	biological_process	intracellular signal transduction
C	0003924	molecular_function	GTPase activity
C	0005525	molecular_function	GTP binding
C	0007264	biological_process	small GTPase-mediated signal transduction
D	0005085	molecular_function	guanyl-nucleotide exchange factor activity
D	0035556	biological_process	intracellular signal transduction

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue GDP A 200

Chain	Residue
A	ASP11
A	LEU119
A	SER158
A	ALA159
A	LEU160
A	ALA13
A	VAL14
A	GLY15
A	LYS16
A	THR17
A	CYS18
A	GLN116
A	ASP118

---

site_id	AC2
Number of Residues	20
Details	binding site for residue FMN B 1801

Chain	Residue
B	VAL1321
B	THR1323
B	ASN1330
B	ASN1354
B	CYS1355
B	ARG1356
B	LEU1358
B	GLN1359
B	VAL1368
B	ILE1371
B	ARG1372
B	ILE1375
B	LEU1385
B	ASN1387
B	ASN1397
B	PHE1399
B	LEU1401
B	PHE1414
B	GLY1416
B	GLN1418

---

site_id	AC3
Number of Residues	13
Details	binding site for residue GDP C 201

Chain	Residue
C	ASP11
C	ALA13
C	VAL14
C	GLY15
C	LYS16
C	THR17
C	CYS18
C	GLN116
C	ASP118
C	LEU119
C	SER158
C	ALA159
C	LEU160

---

site_id	AC4
Number of Residues	19
Details	binding site for residue FMN D 1801

Chain	Residue
A	GLY164
D	VAL1321
D	THR1323
D	ASN1330
D	ASN1354
D	CYS1355
D	ARG1356
D	LEU1358
D	GLN1359
D	ARG1372
D	ILE1375
D	LEU1385
D	ASN1387
D	ASN1397
D	PHE1399
D	LEU1401
D	PHE1414
D	GLY1416
D	GLN1418

---

Functional Information from PROSITE/UniProt

site_id	PS00741
Number of Residues	26
Details	DH_1 Dbl homology (DH) domain signature. LssFIlkPMqrVtRypLiIkNIlenT

Chain	Residue	Details
B	LEU1514-THR1539

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING:

Chain	Residue	Details
A	GLY10
A	THR115
C	GLY10
C	THR115

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	ASP57
C	ASP57

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: (Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate => ECO:0000269|PubMed:19362538, ECO:0000269|PubMed:20622875

Chain	Residue	Details
A	TYR32
C	TYR32

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: (Microbial infection) O-AMP-threonine; by Vibrio VopS => ECO:0000269|PubMed:19039103

Chain	Residue	Details
A	THR35
C	THR35

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphotyrosine; by SRC => ECO:0000269|PubMed:14506284

Chain	Residue	Details
A	TYR64
C	TYR64

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Cysteine methyl ester => ECO:0000269|PubMed:10676816, ECO:0007744|PDB:1DOA

Chain	Residue	Details
A	SER188
C	SER188

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	LIPID: S-geranylgeranyl cysteine => ECO:0000269|PubMed:10676816, ECO:0007744|PDB:1DOA

Chain	Residue	Details
A	SER188
C	SER188

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	CARBOHYD: (Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate => ECO:0000269|PubMed:24141704

Chain	Residue	Details
A	TYR32
C	TYR32

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	CARBOHYD: (Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB; alternate => ECO:0000269|PubMed:24905543, ECO:0000269|PubMed:7775453, ECO:0000269|PubMed:7777059

Chain	Residue	Details
A	THR35
C	THR35

---