5EBT

Tankyrase 1 with Phthalazinone 2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003950	molecular_function	NAD+ ADP-ribosyltransferase activity
B	0003950	molecular_function	NAD+ ADP-ribosyltransferase activity
C	0003950	molecular_function	NAD+ ADP-ribosyltransferase activity
D	0003950	molecular_function	NAD+ ADP-ribosyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue BU3 A 1401

Chain	Residue
A	ALA1202
A	TYR1203
A	PHE1208
A	GLY1209
A	5N81402
A	HOH1521

---

site_id	AC2
Number of Residues	17
Details	binding site for residue 5N8 A 1402

Chain	Residue
A	PHE1197
A	ASP1198
A	HIS1201
A	ALA1202
A	PHE1208
A	GLY1211
A	ILE1212
A	TYR1213
A	SER1221
A	TYR1224
A	ILE1228
A	GLU1291
A	BU31401
A	HOH1516
A	HIS1184
A	GLY1185
A	PHE1188

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 1403

Chain	Residue
A	CYS1234
A	HIS1237
A	CYS1242
A	CYS1245

---

site_id	AC4
Number of Residues	17
Details	binding site for residue 5N8 B 1401

Chain	Residue
B	HIS1184
B	GLY1185
B	PHE1188
B	PHE1197
B	ASP1198
B	HIS1201
B	ALA1202
B	PHE1208
B	GLY1211
B	ILE1212
B	TYR1213
B	LYS1220
B	SER1221
B	TYR1224
B	ILE1228
B	GLU1291
B	HOH1508

---

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN B 1402

Chain	Residue
B	CYS1234
B	HIS1237
B	CYS1242
B	CYS1245

---

site_id	AC6
Number of Residues	7
Details	binding site for residue BU3 C 1401

Chain	Residue
C	ALA1202
C	TYR1203
C	GLY1205
C	PHE1208
C	GLY1209
C	5N81402
C	HOH1512

---

site_id	AC7
Number of Residues	19
Details	binding site for residue 5N8 C 1402

Chain	Residue
C	HIS1184
C	GLY1185
C	PHE1188
C	PHE1197
C	ASP1198
C	HIS1201
C	ALA1202
C	PHE1208
C	GLY1211
C	ILE1212
C	TYR1213
C	LYS1220
C	SER1221
C	TYR1224
C	ILE1228
C	GLU1291
C	BU31401
C	HOH1539
C	HOH1566

---

site_id	AC8
Number of Residues	4
Details	binding site for residue ZN C 1403

Chain	Residue
C	CYS1234
C	HIS1237
C	CYS1242
C	CYS1245

---

site_id	AC9
Number of Residues	4
Details	binding site for residue ZN D 1401

Chain	Residue
D	CYS1234
D	HIS1237
D	CYS1242
D	CYS1245

---

site_id	AD1
Number of Residues	16
Details	binding site for residue 5N8 D 1402

Chain	Residue
D	HIS1184
D	GLY1185
D	PHE1188
D	PHE1197
D	ASP1198
D	HIS1201
D	ALA1202
D	PHE1208
D	GLY1211
D	ILE1212
D	TYR1213
D	SER1221
D	TYR1224
D	ILE1228
D	HOH1511
D	HOH1524

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269|PubMed:18436240, ECO:0007744|PDB:2RF5, ECO:0007744|PDB:3UDD, ECO:0007744|PDB:3UH2, ECO:0007744|PDB:3UH4, ECO:0007744|PDB:4DVI, ECO:0007744|PDB:4I9I, ECO:0007744|PDB:4K4E, ECO:0007744|PDB:4K4F, ECO:0007744|PDB:4KRS, ECO:0007744|PDB:4LI6, ECO:0007744|PDB:4LI8, ECO:0007744|PDB:4MSG, ECO:0007744|PDB:4MSK, ECO:0007744|PDB:4MT9, ECO:0007744|PDB:4N3R, ECO:0007744|PDB:4N4V, ECO:0007744|PDB:4OA7, ECO:0007744|PDB:4TOR, ECO:0007744|PDB:4TOS, ECO:0007744|PDB:4W5S, ECO:0007744|PDB:4W6E

Chain	Residue	Details
A	CYS1234
A	HIS1237
A	CYS1242
A	CYS1245
B	CYS1234
B	HIS1237
B	CYS1242
B	CYS1245
C	CYS1234
C	HIS1237
C	CYS1242
C	CYS1245
D	CYS1234
D	HIS1237
D	CYS1242
D	CYS1245

---