5E7M
Crystal structure of the active catalytic core of the human DEAD-box protein DDX3 bound to AMPPNP
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue ANP A 801 |
| Chain | Residue |
| A | TYR200 |
| A | LYS230 |
| A | THR231 |
| A | LEU278 |
| A | GLN281 |
| A | GLU285 |
| A | GLU348 |
| A | HOH902 |
| A | ARG202 |
| A | PRO203 |
| A | THR204 |
| A | GLN207 |
| A | THR226 |
| A | GLY227 |
| A | SER228 |
| A | GLY229 |
Functional Information from PROSITE/UniProt
| site_id | PS00039 |
| Number of Residues | 9 |
| Details | DEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. VLDEADRmL |
| Chain | Residue | Details |
| A | VAL345-LEU353 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | TYR200 | |
| A | ALA224 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphoserine; by TBK1; in vitro => ECO:0000269|PubMed:18583960 |
| Chain | Residue | Details |
| A | SER181 | |
| A | SER240 | |
| A | SER269 | |
| A | SER442 | |
| A | SER456 | |
| A | SER520 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by TBK1 => ECO:0000269|PubMed:18583960, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER183 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by CSNK1E and TBK1; in vitro => ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:29222110 |
| Chain | Residue | Details |
| A | SER429 | |
| A | SER543 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by TBK1; in vitro => ECO:0000269|PubMed:18583960 |
| Chain | Residue | Details |
| A | THR438 | |
| A | THR542 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by CSNK1E; in vitro => ECO:0000269|PubMed:29222110 |
| Chain | Residue | Details |
| A | THR469 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by CSNK1E; in vitro => ECO:0000269|PubMed:29222110 |
| Chain | Residue | Details |
| A | SER470 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | LYS215 |
