4QI9

Crystal structure of dihydrofolate reductase from Yersinia pestis complexed with methotrexate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004146	molecular_function	dihydrofolate reductase activity
A	0005829	cellular_component	cytosol
A	0006545	biological_process	glycine biosynthetic process
A	0006730	biological_process	one-carbon metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0046452	biological_process	dihydrofolate metabolic process
A	0046654	biological_process	tetrahydrofolate biosynthetic process
A	0046655	biological_process	folic acid metabolic process
A	0046872	molecular_function	metal ion binding
A	0050661	molecular_function	NADP binding
B	0004146	molecular_function	dihydrofolate reductase activity
B	0005829	cellular_component	cytosol
B	0006545	biological_process	glycine biosynthetic process
B	0006730	biological_process	one-carbon metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0046452	biological_process	dihydrofolate metabolic process
B	0046654	biological_process	tetrahydrofolate biosynthetic process
B	0046655	biological_process	folic acid metabolic process
B	0046872	molecular_function	metal ion binding
B	0050661	molecular_function	NADP binding
C	0004146	molecular_function	dihydrofolate reductase activity
C	0005829	cellular_component	cytosol
C	0006545	biological_process	glycine biosynthetic process
C	0006730	biological_process	one-carbon metabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0046452	biological_process	dihydrofolate metabolic process
C	0046654	biological_process	tetrahydrofolate biosynthetic process
C	0046655	biological_process	folic acid metabolic process
C	0046872	molecular_function	metal ion binding
C	0050661	molecular_function	NADP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE MTX A 201

Chain	Residue
A	ILE6
A	TYR101
A	THR114
A	HOH303
A	HOH305
A	ALA7
A	ASP28
A	PHE32
A	LYS33
A	ARG53
A	LEU55
A	ARG58
A	MSE95

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site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE MTX B 201

Chain	Residue
B	ILE6
B	ALA7
B	ALA8
B	ASP28
B	LYS33
B	ARG53
B	ARG58
B	MSE95
B	TYR101
B	THR114
B	HOH302
B	HOH317

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site_id	AC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE MTX C 201

Chain	Residue
C	ILE6
C	ALA7
C	ALA8
C	ASP28
C	PHE32
C	LYS33
C	ARG53
C	LEU55
C	ARG58
C	MSE95
C	TYR101
C	THR114
C	HOH318

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Functional Information from PROSITE/UniProt

site_id	PS00075
Number of Residues	23
Details	DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGmenaMPWhlpa.DlawFkrnT

Chain	Residue	Details
A	VAL14-THR36

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