4OV6
Crystal structure of PCSK9(53-451) with Adnectin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0004252 | molecular_function | serine-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008236 | molecular_function | serine-type peptidase activity |
| E | 0004252 | molecular_function | serine-type endopeptidase activity |
| E | 0006508 | biological_process | proteolysis |
| E | 0008236 | molecular_function | serine-type peptidase activity |
| F | 0005178 | molecular_function | integrin binding |
| F | 0005201 | molecular_function | extracellular matrix structural constituent |
| F | 0007044 | biological_process | cell-substrate junction assembly |
| F | 0007160 | biological_process | cell-matrix adhesion |
| F | 0007399 | biological_process | nervous system development |
| F | 0007507 | biological_process | heart development |
| F | 0043394 | molecular_function | proteoglycan binding |
| G | 0005178 | molecular_function | integrin binding |
| G | 0005201 | molecular_function | extracellular matrix structural constituent |
| G | 0007044 | biological_process | cell-substrate junction assembly |
| G | 0007160 | biological_process | cell-matrix adhesion |
| G | 0007399 | biological_process | nervous system development |
| G | 0007507 | biological_process | heart development |
| G | 0043394 | molecular_function | proteoglycan binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 201 |
| Chain | Residue |
| A | TRP72 |
| A | PHE150 |
| B | LYS258 |
| F | HIS80 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO B 501 |
| Chain | Residue |
| B | PHE318 |
| B | ARG319 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO B 502 |
| Chain | Residue |
| B | PHE379 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PG4 B 503 |
| Chain | Residue |
| E | GLN413 |
| B | GLN413 |
| B | ILE416 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PG4 D 201 |
| Chain | Residue |
| D | LEU108 |
| D | LYS125 |
| D | MET126 |
| D | HOH308 |
Functional Information from PROSITE/UniProt
| site_id | PS00687 |
| Number of Residues | 8 |
| Details | ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. GETGGNSP |
| Chain | Residue | Details |
| F | GLY37-PRO44 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | ACT_SITE: Charge relay system => ECO:0000255|PROSITE-ProRule:PRU01240 |
| Chain | Residue | Details |
| B | ASP186 | |
| B | HIS226 | |
| B | SER386 | |
| E | ASP186 | |
| E | HIS226 | |
| E | SER386 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by furin and PCSK5 => ECO:0000269|PubMed:16912035 |
| Chain | Residue | Details |
| B | ARG218 | |
| E | ARG218 |
