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4OV6

Crystal structure of PCSK9(53-451) with Adnectin

Summary for 4OV6
Entry DOI10.2210/pdb4ov6/pdb
DescriptorProprotein convertase subtilisin/kexin type 9, Adnectin, 1,2-ETHANEDIOL, ... (6 entities in total)
Functional Keywordspcsk9, adnectin, ldl-cholesterol, hydrolase-protein binding complex, hydrolase/protein binding
Biological sourceHomo sapiens (human)
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Cellular locationCytoplasm: Q8NBP7 Q8NBP7
Total number of polymer chains6
Total formula weight106200.01
Authors
Khan, J.A. (deposition date: 2014-02-20, release date: 2014-07-02, Last modification date: 2017-11-22)
Primary citationMitchell, T.,Chao, G.,Sitkoff, D.,Lo, F.,Monshizadegan, H.,Meyers, D.,Low, S.,Russo, K.,DiBella, R.,Denhez, F.,Gao, M.,Myers, J.,Duke, G.,Witmer, M.,Miao, B.,Ho, S.P.,Khan, J.,Parker, R.A.
Pharmacologic Profile of the Adnectin BMS-962476, a Small Protein Biologic Alternative to PCSK9 Antibodies for Low-Density Lipoprotein Lowering.
J.Pharmacol.Exp.Ther., 350:412-424, 2014
Cited by
PubMed: 24917546
DOI: 10.1124/jpet.114.214221
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.69 Å)
Structure validation

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