4OV6
Crystal structure of PCSK9(53-451) with Adnectin
Summary for 4OV6
Entry DOI | 10.2210/pdb4ov6/pdb |
Descriptor | Proprotein convertase subtilisin/kexin type 9, Adnectin, 1,2-ETHANEDIOL, ... (6 entities in total) |
Functional Keywords | pcsk9, adnectin, ldl-cholesterol, hydrolase-protein binding complex, hydrolase/protein binding |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm: Q8NBP7 Q8NBP7 |
Total number of polymer chains | 6 |
Total formula weight | 106200.01 |
Authors | Khan, J.A. (deposition date: 2014-02-20, release date: 2014-07-02, Last modification date: 2017-11-22) |
Primary citation | Mitchell, T.,Chao, G.,Sitkoff, D.,Lo, F.,Monshizadegan, H.,Meyers, D.,Low, S.,Russo, K.,DiBella, R.,Denhez, F.,Gao, M.,Myers, J.,Duke, G.,Witmer, M.,Miao, B.,Ho, S.P.,Khan, J.,Parker, R.A. Pharmacologic Profile of the Adnectin BMS-962476, a Small Protein Biologic Alternative to PCSK9 Antibodies for Low-Density Lipoprotein Lowering. J.Pharmacol.Exp.Ther., 350:412-424, 2014 Cited by PubMed: 24917546DOI: 10.1124/jpet.114.214221 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.69 Å) |
Structure validation
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