4KIT
Crystal structure of human Brr2 in complex with the Prp8 Jab1/MPN domain
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0005524 | molecular_function | ATP binding |
| C | 0000398 | biological_process | mRNA splicing, via spliceosome |
| C | 0005681 | cellular_component | spliceosomal complex |
| C | 0008233 | molecular_function | peptidase activity |
| C | 0008237 | molecular_function | metallopeptidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE ADP B 2201 |
| Chain | Residue |
| B | THR480 |
| B | GLN485 |
| B | GLY508 |
| B | LYS509 |
| B | THR510 |
| B | ASP615 |
| B | GLU616 |
| B | ASN820 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE ADP B 2202 |
| Chain | Residue |
| B | PHE1327 |
| B | GLN1332 |
| B | GLY1353 |
| B | SER1354 |
| B | GLY1355 |
| B | LYS1356 |
| B | THR1357 |
| B | GLU1455 |
| B | PRO1694 |
| B | MG2203 |
| B | PHE1325 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG B 2203 |
| Chain | Residue |
| B | THR1357 |
| B | ASP1454 |
| B | ADP2202 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00541, ECO:0000269|PubMed:23045696, ECO:0007744|PDB:4F93 |
| Chain | Residue | Details |
| B | ALA503 | |
| B | ALA1350 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:F1LNJ2 |
| Chain | Residue | Details |
| B | TYR709 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| B | LYS971 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | THR1428 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q6P4T2 |
| Chain | Residue | Details |
| B | THR1765 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | SER2002 |
