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4KIT

Crystal structure of human Brr2 in complex with the Prp8 Jab1/MPN domain

Summary for 4KIT
Entry DOI10.2210/pdb4kit/pdb
DescriptorU5 small nuclear ribonucleoprotein 200 kDa helicase, Pre-mRNA-processing-splicing factor 8, ADENOSINE-5'-DIPHOSPHATE, ... (4 entities in total)
Functional Keywordsreca domain, winged helix domain, sec63 unit, jab1/mpn domain, pre-mrna splicing, atp binding, rna binding, ubiquitin binding, rna binding protein
Biological sourceHomo sapiens (human)
More
Cellular locationNucleus: O75643
Nucleus speckle (By similarity): Q6P2Q9
Total number of polymer chains2
Total formula weight231525.49
Authors
Wahl, M.C.,Wandersleben, T.,Santos, K.F. (deposition date: 2013-05-02, release date: 2013-06-05, Last modification date: 2023-09-20)
Primary citationMozaffari-Jovin, S.,Wandersleben, T.,Santos, K.F.,Will, C.L.,Luhrmann, R.,Wahl, M.C.
Inhibition of RNA helicase Brr2 by the C-terminal tail of the spliceosomal protein Prp8.
Science, 341:80-84, 2013
Cited by
PubMed: 23704370
DOI: 10.1126/science.1237515
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.598 Å)
Structure validation

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