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4IZ5

Structure of the complex between ERK2 phosphomimetic mutant and PEA-15

Functional Information from GO Data
ChainGOidnamespacecontents
A0000165biological_processMAPK cascade
A0001784molecular_functionphosphotyrosine residue binding
A0003677molecular_functionDNA binding
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004707molecular_functionMAP kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005576cellular_componentextracellular region
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005769cellular_componentearly endosome
A0005770cellular_componentlate endosome
A0005788cellular_componentendoplasmic reticulum lumen
A0005794cellular_componentGolgi apparatus
A0005813cellular_componentcentrosome
A0005819cellular_componentspindle
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0005901cellular_componentcaveola
A0005925cellular_componentfocal adhesion
A0006357biological_processregulation of transcription by RNA polymerase II
A0006468biological_processprotein phosphorylation
A0006915biological_processapoptotic process
A0006935biological_processchemotaxis
A0006974biological_processDNA damage response
A0007165biological_processsignal transduction
A0007166biological_processcell surface receptor signaling pathway
A0007268biological_processchemical synaptic transmission
A0007507biological_processheart development
A0007611biological_processlearning or memory
A0008286biological_processinsulin receptor signaling pathway
A0008353molecular_functionRNA polymerase II CTD heptapeptide repeat kinase activity
A0009887biological_processanimal organ morphogenesis
A0010759biological_processpositive regulation of macrophage chemotaxis
A0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
A0014032biological_processneural crest cell development
A0014044biological_processSchwann cell development
A0016020cellular_componentmembrane
A0016301molecular_functionkinase activity
A0018105biological_processpeptidyl-serine phosphorylation
A0018107biological_processpeptidyl-threonine phosphorylation
A0019858biological_processcytosine metabolic process
A0019902molecular_functionphosphatase binding
A0030278biological_processregulation of ossification
A0030521biological_processandrogen receptor signaling pathway
A0030641biological_processregulation of cellular pH
A0030878biological_processthyroid gland development
A0031143cellular_componentpseudopodium
A0031647biological_processregulation of protein stability
A0031663biological_processlipopolysaccharide-mediated signaling pathway
A0032212biological_processpositive regulation of telomere maintenance via telomerase
A0032496biological_processresponse to lipopolysaccharide
A0032872biological_processregulation of stress-activated MAPK cascade
A0033598biological_processmammary gland epithelial cell proliferation
A0034198biological_processcellular response to amino acid starvation
A0034614biological_processcellular response to reactive oxygen species
A0035094biological_processresponse to nicotine
A0035556biological_processintracellular signal transduction
A0035578cellular_componentazurophil granule lumen
A0038127biological_processERBB signaling pathway
A0038133biological_processERBB2-ERBB3 signaling pathway
A0042473biological_processouter ear morphogenesis
A0042552biological_processmyelination
A0042802molecular_functionidentical protein binding
A0043330biological_processresponse to exogenous dsRNA
A0043401biological_processsteroid hormone mediated signaling pathway
A0045202cellular_componentsynapse
A0045596biological_processnegative regulation of cell differentiation
A0048009biological_processinsulin-like growth factor receptor signaling pathway
A0048538biological_processthymus development
A0050847biological_processprogesterone receptor signaling pathway
A0050852biological_processT cell receptor signaling pathway
A0050853biological_processB cell receptor signaling pathway
A0051403biological_processstress-activated MAPK cascade
A0051493biological_processregulation of cytoskeleton organization
A0051973biological_processpositive regulation of telomerase activity
A0060020biological_processBergmann glial cell differentiation
A0060291biological_processlong-term synaptic potentiation
A0060324biological_processface development
A0060425biological_processlung morphogenesis
A0060440biological_processtrachea formation
A0060716biological_processlabyrinthine layer blood vessel development
A0061308biological_processcardiac neural crest cell development involved in heart development
A0070161cellular_componentanchoring junction
A0070371biological_processERK1 and ERK2 cascade
A0070849biological_processresponse to epidermal growth factor
A0071276biological_processcellular response to cadmium ion
A0071356biological_processcellular response to tumor necrosis factor
A0072584biological_processcaveolin-mediated endocytosis
A0072686cellular_componentmitotic spindle
A0090170biological_processregulation of Golgi inheritance
A0106310molecular_functionprotein serine kinase activity
A0120041biological_processpositive regulation of macrophage proliferation
A1904355biological_processpositive regulation of telomere capping
A1904813cellular_componentficolin-1-rich granule lumen
A2000641biological_processregulation of early endosome to late endosome transport
B0000165biological_processMAPK cascade
B0001784molecular_functionphosphotyrosine residue binding
B0003677molecular_functionDNA binding
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0004707molecular_functionMAP kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005576cellular_componentextracellular region
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005769cellular_componentearly endosome
B0005770cellular_componentlate endosome
B0005788cellular_componentendoplasmic reticulum lumen
B0005794cellular_componentGolgi apparatus
B0005813cellular_componentcentrosome
B0005819cellular_componentspindle
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005886cellular_componentplasma membrane
B0005901cellular_componentcaveola
B0005925cellular_componentfocal adhesion
B0006357biological_processregulation of transcription by RNA polymerase II
B0006468biological_processprotein phosphorylation
B0006915biological_processapoptotic process
B0006935biological_processchemotaxis
B0006974biological_processDNA damage response
B0007165biological_processsignal transduction
B0007166biological_processcell surface receptor signaling pathway
B0007268biological_processchemical synaptic transmission
B0007507biological_processheart development
B0007611biological_processlearning or memory
B0008286biological_processinsulin receptor signaling pathway
B0008353molecular_functionRNA polymerase II CTD heptapeptide repeat kinase activity
B0009887biological_processanimal organ morphogenesis
B0010759biological_processpositive regulation of macrophage chemotaxis
B0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
B0014032biological_processneural crest cell development
B0014044biological_processSchwann cell development
B0016020cellular_componentmembrane
B0016301molecular_functionkinase activity
B0018105biological_processpeptidyl-serine phosphorylation
B0018107biological_processpeptidyl-threonine phosphorylation
B0019858biological_processcytosine metabolic process
B0019902molecular_functionphosphatase binding
B0030278biological_processregulation of ossification
B0030521biological_processandrogen receptor signaling pathway
B0030641biological_processregulation of cellular pH
B0030878biological_processthyroid gland development
B0031143cellular_componentpseudopodium
B0031647biological_processregulation of protein stability
B0031663biological_processlipopolysaccharide-mediated signaling pathway
B0032212biological_processpositive regulation of telomere maintenance via telomerase
B0032496biological_processresponse to lipopolysaccharide
B0032872biological_processregulation of stress-activated MAPK cascade
B0033598biological_processmammary gland epithelial cell proliferation
B0034198biological_processcellular response to amino acid starvation
B0034614biological_processcellular response to reactive oxygen species
B0035094biological_processresponse to nicotine
B0035556biological_processintracellular signal transduction
B0035578cellular_componentazurophil granule lumen
B0038127biological_processERBB signaling pathway
B0038133biological_processERBB2-ERBB3 signaling pathway
B0042473biological_processouter ear morphogenesis
B0042552biological_processmyelination
B0042802molecular_functionidentical protein binding
B0043330biological_processresponse to exogenous dsRNA
B0043401biological_processsteroid hormone mediated signaling pathway
B0045202cellular_componentsynapse
B0045596biological_processnegative regulation of cell differentiation
B0048009biological_processinsulin-like growth factor receptor signaling pathway
B0048538biological_processthymus development
B0050847biological_processprogesterone receptor signaling pathway
B0050852biological_processT cell receptor signaling pathway
B0050853biological_processB cell receptor signaling pathway
B0051403biological_processstress-activated MAPK cascade
B0051493biological_processregulation of cytoskeleton organization
B0051973biological_processpositive regulation of telomerase activity
B0060020biological_processBergmann glial cell differentiation
B0060291biological_processlong-term synaptic potentiation
B0060324biological_processface development
B0060425biological_processlung morphogenesis
B0060440biological_processtrachea formation
B0060716biological_processlabyrinthine layer blood vessel development
B0061308biological_processcardiac neural crest cell development involved in heart development
B0070161cellular_componentanchoring junction
B0070371biological_processERK1 and ERK2 cascade
B0070849biological_processresponse to epidermal growth factor
B0071276biological_processcellular response to cadmium ion
B0071356biological_processcellular response to tumor necrosis factor
B0072584biological_processcaveolin-mediated endocytosis
B0072686cellular_componentmitotic spindle
B0090170biological_processregulation of Golgi inheritance
B0106310molecular_functionprotein serine kinase activity
B0120041biological_processpositive regulation of macrophage proliferation
B1904355biological_processpositive regulation of telomere capping
B1904813cellular_componentficolin-1-rich granule lumen
B2000641biological_processregulation of early endosome to late endosome transport
C0000165biological_processMAPK cascade
C0001784molecular_functionphosphotyrosine residue binding
C0003677molecular_functionDNA binding
C0004672molecular_functionprotein kinase activity
C0004674molecular_functionprotein serine/threonine kinase activity
C0004707molecular_functionMAP kinase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005576cellular_componentextracellular region
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005769cellular_componentearly endosome
C0005770cellular_componentlate endosome
C0005788cellular_componentendoplasmic reticulum lumen
C0005794cellular_componentGolgi apparatus
C0005813cellular_componentcentrosome
C0005819cellular_componentspindle
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005886cellular_componentplasma membrane
C0005901cellular_componentcaveola
C0005925cellular_componentfocal adhesion
C0006357biological_processregulation of transcription by RNA polymerase II
C0006468biological_processprotein phosphorylation
C0006915biological_processapoptotic process
C0006935biological_processchemotaxis
C0006974biological_processDNA damage response
C0007165biological_processsignal transduction
C0007166biological_processcell surface receptor signaling pathway
C0007268biological_processchemical synaptic transmission
C0007507biological_processheart development
C0007611biological_processlearning or memory
C0008286biological_processinsulin receptor signaling pathway
C0008353molecular_functionRNA polymerase II CTD heptapeptide repeat kinase activity
C0009887biological_processanimal organ morphogenesis
C0010759biological_processpositive regulation of macrophage chemotaxis
C0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
C0014032biological_processneural crest cell development
C0014044biological_processSchwann cell development
C0016020cellular_componentmembrane
C0016301molecular_functionkinase activity
C0018105biological_processpeptidyl-serine phosphorylation
C0018107biological_processpeptidyl-threonine phosphorylation
C0019858biological_processcytosine metabolic process
C0019902molecular_functionphosphatase binding
C0030278biological_processregulation of ossification
C0030521biological_processandrogen receptor signaling pathway
C0030641biological_processregulation of cellular pH
C0030878biological_processthyroid gland development
C0031143cellular_componentpseudopodium
C0031647biological_processregulation of protein stability
C0031663biological_processlipopolysaccharide-mediated signaling pathway
C0032212biological_processpositive regulation of telomere maintenance via telomerase
C0032496biological_processresponse to lipopolysaccharide
C0032872biological_processregulation of stress-activated MAPK cascade
C0033598biological_processmammary gland epithelial cell proliferation
C0034198biological_processcellular response to amino acid starvation
C0034614biological_processcellular response to reactive oxygen species
C0035094biological_processresponse to nicotine
C0035556biological_processintracellular signal transduction
C0035578cellular_componentazurophil granule lumen
C0038127biological_processERBB signaling pathway
C0038133biological_processERBB2-ERBB3 signaling pathway
C0042473biological_processouter ear morphogenesis
C0042552biological_processmyelination
C0042802molecular_functionidentical protein binding
C0043330biological_processresponse to exogenous dsRNA
C0043401biological_processsteroid hormone mediated signaling pathway
C0045202cellular_componentsynapse
C0045596biological_processnegative regulation of cell differentiation
C0048009biological_processinsulin-like growth factor receptor signaling pathway
C0048538biological_processthymus development
C0050847biological_processprogesterone receptor signaling pathway
C0050852biological_processT cell receptor signaling pathway
C0050853biological_processB cell receptor signaling pathway
C0051403biological_processstress-activated MAPK cascade
C0051493biological_processregulation of cytoskeleton organization
C0051973biological_processpositive regulation of telomerase activity
C0060020biological_processBergmann glial cell differentiation
C0060291biological_processlong-term synaptic potentiation
C0060324biological_processface development
C0060425biological_processlung morphogenesis
C0060440biological_processtrachea formation
C0060716biological_processlabyrinthine layer blood vessel development
C0061308biological_processcardiac neural crest cell development involved in heart development
C0070161cellular_componentanchoring junction
C0070371biological_processERK1 and ERK2 cascade
C0070849biological_processresponse to epidermal growth factor
C0071276biological_processcellular response to cadmium ion
C0071356biological_processcellular response to tumor necrosis factor
C0072584biological_processcaveolin-mediated endocytosis
C0072686cellular_componentmitotic spindle
C0090170biological_processregulation of Golgi inheritance
C0106310molecular_functionprotein serine kinase activity
C0120041biological_processpositive regulation of macrophage proliferation
C1904355biological_processpositive regulation of telomere capping
C1904813cellular_componentficolin-1-rich granule lumen
C2000641biological_processregulation of early endosome to late endosome transport
D0000165biological_processMAPK cascade
D0001784molecular_functionphosphotyrosine residue binding
D0003677molecular_functionDNA binding
D0004672molecular_functionprotein kinase activity
D0004674molecular_functionprotein serine/threonine kinase activity
D0004707molecular_functionMAP kinase activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005576cellular_componentextracellular region
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005769cellular_componentearly endosome
D0005770cellular_componentlate endosome
D0005788cellular_componentendoplasmic reticulum lumen
D0005794cellular_componentGolgi apparatus
D0005813cellular_componentcentrosome
D0005819cellular_componentspindle
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005886cellular_componentplasma membrane
D0005901cellular_componentcaveola
D0005925cellular_componentfocal adhesion
D0006357biological_processregulation of transcription by RNA polymerase II
D0006468biological_processprotein phosphorylation
D0006915biological_processapoptotic process
D0006935biological_processchemotaxis
D0006974biological_processDNA damage response
D0007165biological_processsignal transduction
D0007166biological_processcell surface receptor signaling pathway
D0007268biological_processchemical synaptic transmission
D0007507biological_processheart development
D0007611biological_processlearning or memory
D0008286biological_processinsulin receptor signaling pathway
D0008353molecular_functionRNA polymerase II CTD heptapeptide repeat kinase activity
D0009887biological_processanimal organ morphogenesis
D0010759biological_processpositive regulation of macrophage chemotaxis
D0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
D0014032biological_processneural crest cell development
D0014044biological_processSchwann cell development
D0016020cellular_componentmembrane
D0016301molecular_functionkinase activity
D0018105biological_processpeptidyl-serine phosphorylation
D0018107biological_processpeptidyl-threonine phosphorylation
D0019858biological_processcytosine metabolic process
D0019902molecular_functionphosphatase binding
D0030278biological_processregulation of ossification
D0030521biological_processandrogen receptor signaling pathway
D0030641biological_processregulation of cellular pH
D0030878biological_processthyroid gland development
D0031143cellular_componentpseudopodium
D0031647biological_processregulation of protein stability
D0031663biological_processlipopolysaccharide-mediated signaling pathway
D0032212biological_processpositive regulation of telomere maintenance via telomerase
D0032496biological_processresponse to lipopolysaccharide
D0032872biological_processregulation of stress-activated MAPK cascade
D0033598biological_processmammary gland epithelial cell proliferation
D0034198biological_processcellular response to amino acid starvation
D0034614biological_processcellular response to reactive oxygen species
D0035094biological_processresponse to nicotine
D0035556biological_processintracellular signal transduction
D0035578cellular_componentazurophil granule lumen
D0038127biological_processERBB signaling pathway
D0038133biological_processERBB2-ERBB3 signaling pathway
D0042473biological_processouter ear morphogenesis
D0042552biological_processmyelination
D0042802molecular_functionidentical protein binding
D0043330biological_processresponse to exogenous dsRNA
D0043401biological_processsteroid hormone mediated signaling pathway
D0045202cellular_componentsynapse
D0045596biological_processnegative regulation of cell differentiation
D0048009biological_processinsulin-like growth factor receptor signaling pathway
D0048538biological_processthymus development
D0050847biological_processprogesterone receptor signaling pathway
D0050852biological_processT cell receptor signaling pathway
D0050853biological_processB cell receptor signaling pathway
D0051403biological_processstress-activated MAPK cascade
D0051493biological_processregulation of cytoskeleton organization
D0051973biological_processpositive regulation of telomerase activity
D0060020biological_processBergmann glial cell differentiation
D0060291biological_processlong-term synaptic potentiation
D0060324biological_processface development
D0060425biological_processlung morphogenesis
D0060440biological_processtrachea formation
D0060716biological_processlabyrinthine layer blood vessel development
D0061308biological_processcardiac neural crest cell development involved in heart development
D0070161cellular_componentanchoring junction
D0070371biological_processERK1 and ERK2 cascade
D0070849biological_processresponse to epidermal growth factor
D0071276biological_processcellular response to cadmium ion
D0071356biological_processcellular response to tumor necrosis factor
D0072584biological_processcaveolin-mediated endocytosis
D0072686cellular_componentmitotic spindle
D0090170biological_processregulation of Golgi inheritance
D0106310molecular_functionprotein serine kinase activity
D0120041biological_processpositive regulation of macrophage proliferation
D1904355biological_processpositive regulation of telomere capping
D1904813cellular_componentficolin-1-rich granule lumen
D2000641biological_processregulation of early endosome to late endosome transport
E0000165biological_processMAPK cascade
E0005515molecular_functionprotein binding
E0005654cellular_componentnucleoplasm
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0005875cellular_componentmicrotubule associated complex
E0006915biological_processapoptotic process
E0042981biological_processregulation of apoptotic process
E0043231cellular_componentintracellular membrane-bounded organelle
E0046325biological_processnegative regulation of glucose import
E0071702biological_processorganic substance transport
E1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
E1902043biological_processpositive regulation of extrinsic apoptotic signaling pathway via death domain receptors
F0000165biological_processMAPK cascade
F0005515molecular_functionprotein binding
F0005654cellular_componentnucleoplasm
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0005875cellular_componentmicrotubule associated complex
F0006915biological_processapoptotic process
F0042981biological_processregulation of apoptotic process
F0043231cellular_componentintracellular membrane-bounded organelle
F0046325biological_processnegative regulation of glucose import
F0071702biological_processorganic substance transport
F1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
F1902043biological_processpositive regulation of extrinsic apoptotic signaling pathway via death domain receptors
G0000165biological_processMAPK cascade
G0005515molecular_functionprotein binding
G0005654cellular_componentnucleoplasm
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0005875cellular_componentmicrotubule associated complex
G0006915biological_processapoptotic process
G0042981biological_processregulation of apoptotic process
G0043231cellular_componentintracellular membrane-bounded organelle
G0046325biological_processnegative regulation of glucose import
G0071702biological_processorganic substance transport
G1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
G1902043biological_processpositive regulation of extrinsic apoptotic signaling pathway via death domain receptors
H0000165biological_processMAPK cascade
H0005515molecular_functionprotein binding
H0005654cellular_componentnucleoplasm
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0005875cellular_componentmicrotubule associated complex
H0006915biological_processapoptotic process
H0042981biological_processregulation of apoptotic process
H0043231cellular_componentintracellular membrane-bounded organelle
H0046325biological_processnegative regulation of glucose import
H0071702biological_processorganic substance transport
H1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
H1902043biological_processpositive regulation of extrinsic apoptotic signaling pathway via death domain receptors
Functional Information from PDB Data
site_idAC1
Number of Residues11
DetailsBINDING SITE FOR RESIDUE ADP A 900
ChainResidue
AGLY34
ALYS114
ALEU156
AALA35
AVAL39
AALA52
ALYS54
AASP106
ALEU107
AMET108
AASP111

site_idAC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 A 901
ChainResidue
AARG70
AARG172
AVAL173
AMET333
AGLU334
ALEU335
AASP336

site_idAC3
Number of Residues8
DetailsBINDING SITE FOR RESIDUE SO4 A 902
ChainResidue
AARG148
AARG172
AHIS178
AHIS180
ATHR181
AGLY182
APHE183
ALEU184

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 A 903
ChainResidue
AVAL188
AALA189
ATHR190
BARG15

site_idAC5
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A 904
ChainResidue
AARG191
ALYS231
AHIS232

site_idAC6
Number of Residues11
DetailsBINDING SITE FOR RESIDUE ADP B 900
ChainResidue
BGLY34
BALA35
BVAL39
BALA52
BLYS54
BGLN105
BASP106
BMET108
BASP111
BLYS114
BLEU156

site_idAC7
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 B 901
ChainResidue
BARG70
BARG172
BVAL173
BMET333
BGLU334
BLEU335
BASP336

site_idAC8
Number of Residues8
DetailsBINDING SITE FOR RESIDUE SO4 B 902
ChainResidue
BARG148
BARG172
BHIS178
BHIS180
BTHR181
BGLY182
BPHE183
BLEU184

site_idAC9
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 B 903
ChainResidue
AARG15
BVAL188
BALA189
BTHR190

site_idBC1
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SO4 B 904
ChainResidue
BARG191
BHIS232

site_idBC2
Number of Residues12
DetailsBINDING SITE FOR RESIDUE ADP C 900
ChainResidue
CGLY34
CALA35
CVAL39
CALA52
CLYS54
CGLN105
CASP106
CMET108
CASP111
CLYS114
CSER153
CLEU156

site_idBC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 C 901
ChainResidue
CARG70
CARG172
CVAL173
CMET333
CGLU334
CLEU335
CASP336

site_idBC4
Number of Residues8
DetailsBINDING SITE FOR RESIDUE SO4 C 902
ChainResidue
CARG148
CARG172
CHIS178
CHIS180
CTHR181
CGLY182
CPHE183
CLEU184

site_idBC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 C 903
ChainResidue
CTYR187
CVAL188
CALA189
CTHR190
DARG15

site_idBC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 C 904
ChainResidue
CHIS232
CARG191
CLYS231

site_idBC7
Number of Residues12
DetailsBINDING SITE FOR RESIDUE ADP D 900
ChainResidue
DGLY34
DALA35
DVAL39
DALA52
DLYS54
DGLN105
DASP106
DLEU107
DMET108
DASP111
DLYS114
DSER153

site_idBC8
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 D 901
ChainResidue
DARG70
DARG172
DVAL173
DMET333
DGLU334
DLEU335
DASP336

site_idBC9
Number of Residues8
DetailsBINDING SITE FOR RESIDUE SO4 D 902
ChainResidue
DARG148
DARG172
DHIS178
DHIS180
DTHR181
DGLY182
DPHE183
DLEU184

site_idCC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 D 903
ChainResidue
CARG15
DVAL188
DALA189
DTHR190

site_idCC2
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SO4 D 904
ChainResidue
DARG191
DHIS232

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues25
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGAYGMVCsAydnvnkvrv.........AIKK
ChainResidueDetails
AILE31-LYS55

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDLKpsNLLL
ChainResidueDetails
AVAL145-LEU157

site_idPS01351
Number of Residues103
DetailsMAPK MAP kinase signature. FehqtycqrtlREikillrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhicyflyqilrglkyihsanvlh..........RDlKpsnlllnttC
ChainResidueDetails
APHE59-CYS161

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231
ChainResidueDetails
GSER61
HSER61
ESER61
FSER61

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q62048
ChainResidueDetails
ESER90
FSER90
GSER90
HSER90

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
GSER104
HSER104
CILE31
CLYS54
DILE31
DLYS54
ESER104
FSER104

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
GSER116
HSER116
ESER116
FSER116

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: Phosphothreonine; by MAP2K1 and MAP2K2 => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
AGLU185
BGLU185
CGLU185
DGLU185

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: Phosphotyrosine; by MAP2K1 and MAP2K2 => ECO:0000269|PubMed:19053285, ECO:0000269|PubMed:19494114, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
ATYR187
BTYR187
CTYR187
DTYR187

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:19060905
ChainResidueDetails
ATHR190
BTHR190
CTHR190
DTHR190

site_idSWS_FT_FI8
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:18760948
ChainResidueDetails
CSER246
CSER248
DSER246
DSER248
ASER246
ASER248
BSER246
BSER248

site_idSWS_FT_FI9
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19369195
ChainResidueDetails
ASER284
BSER284
CSER284
DSER284

219140

PDB entries from 2024-05-01

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