4IZ5

Structure of the complex between ERK2 phosphomimetic mutant and PEA-15

Summary for 4IZ5

• Entry DOI: 10.2210/pdb4iz5/pdb
• Related: 4IZ7 4IZA
• Descriptor: Mitogen-activated protein kinase 1, Astrocytic phosphoprotein PEA-15, ADENOSINE-5'-DIPHOSPHATE, ... (4 entities in total)
• Functional Keywords: map kinase, death effector domain, transferase
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm, cytoskeleton, spindle (By similarity): P28482; Cytoplasm: Q15121
• Total number of polymer chains: 8
• Total formula weight: 229124.17

Authors

Mace, P.D.,Robinson, H.,Riedl, S.J. (deposition date: 2013-01-29, release date: 2013-04-10, Last modification date: 2024-02-28)

• Primary citation: Mace, P.D.,Wallez, Y.,Egger, M.F.,Dobaczewska, M.K.,Robinson, H.,Pasquale, E.B.,Riedl, S.J.; Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK.; Nat Commun, 4:1681-1681, 2013; PubMed: 23575685; DOI: 10.1038/ncomms2687

Experimental method

X-RAY DIFFRACTION (3.19 Å)