4E45

Crystal structure of the hMHF1/hMHF2 Histone-Fold Tetramer in Complex with Fanconi Anemia Associated Helicase hFANCM

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0046982	molecular_function	protein heterodimerization activity
A	0071821	cellular_component	FANCM-MHF complex
B	0000712	biological_process	resolution of meiotic recombination intermediates
B	0000775	cellular_component	chromosome, centromeric region
B	0000776	cellular_component	kinetochore
B	0000785	cellular_component	chromatin
B	0000939	cellular_component	inner kinetochore
B	0003677	molecular_function	DNA binding
B	0003690	molecular_function	double-stranded DNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005694	cellular_component	chromosome
B	0005829	cellular_component	cytosol
B	0006281	biological_process	DNA repair
B	0006974	biological_process	DNA damage response
B	0007049	biological_process	cell cycle
B	0007059	biological_process	chromosome segregation
B	0031297	biological_process	replication fork processing
B	0031398	biological_process	positive regulation of protein ubiquitination
B	0036297	biological_process	interstrand cross-link repair
B	0043240	cellular_component	Fanconi anaemia nuclear complex
B	0051301	biological_process	cell division
B	0051382	biological_process	kinetochore assembly
B	0071821	cellular_component	FANCM-MHF complex
C	0046982	molecular_function	protein heterodimerization activity
C	0071821	cellular_component	FANCM-MHF complex
D	0000712	biological_process	resolution of meiotic recombination intermediates
D	0000775	cellular_component	chromosome, centromeric region
D	0000776	cellular_component	kinetochore
D	0000785	cellular_component	chromatin
D	0000939	cellular_component	inner kinetochore
D	0003677	molecular_function	DNA binding
D	0003690	molecular_function	double-stranded DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005694	cellular_component	chromosome
D	0005829	cellular_component	cytosol
D	0006281	biological_process	DNA repair
D	0006974	biological_process	DNA damage response
D	0007049	biological_process	cell cycle
D	0007059	biological_process	chromosome segregation
D	0031297	biological_process	replication fork processing
D	0031398	biological_process	positive regulation of protein ubiquitination
D	0036297	biological_process	interstrand cross-link repair
D	0043240	cellular_component	Fanconi anaemia nuclear complex
D	0051301	biological_process	cell division
D	0051382	biological_process	kinetochore assembly
D	0071821	cellular_component	FANCM-MHF complex
F	0046982	molecular_function	protein heterodimerization activity
F	0071821	cellular_component	FANCM-MHF complex
G	0000712	biological_process	resolution of meiotic recombination intermediates
G	0000775	cellular_component	chromosome, centromeric region
G	0000776	cellular_component	kinetochore
G	0000785	cellular_component	chromatin
G	0000939	cellular_component	inner kinetochore
G	0003677	molecular_function	DNA binding
G	0003690	molecular_function	double-stranded DNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005694	cellular_component	chromosome
G	0005829	cellular_component	cytosol
G	0006281	biological_process	DNA repair
G	0006974	biological_process	DNA damage response
G	0007049	biological_process	cell cycle
G	0007059	biological_process	chromosome segregation
G	0031297	biological_process	replication fork processing
G	0031398	biological_process	positive regulation of protein ubiquitination
G	0036297	biological_process	interstrand cross-link repair
G	0043240	cellular_component	Fanconi anaemia nuclear complex
G	0051301	biological_process	cell division
G	0051382	biological_process	kinetochore assembly
G	0071821	cellular_component	FANCM-MHF complex
H	0046982	molecular_function	protein heterodimerization activity
H	0071821	cellular_component	FANCM-MHF complex
I	0000712	biological_process	resolution of meiotic recombination intermediates
I	0000775	cellular_component	chromosome, centromeric region
I	0000776	cellular_component	kinetochore
I	0000785	cellular_component	chromatin
I	0000939	cellular_component	inner kinetochore
I	0003677	molecular_function	DNA binding
I	0003690	molecular_function	double-stranded DNA binding
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005694	cellular_component	chromosome
I	0005829	cellular_component	cytosol
I	0006281	biological_process	DNA repair
I	0006974	biological_process	DNA damage response
I	0007049	biological_process	cell cycle
I	0007059	biological_process	chromosome segregation
I	0031297	biological_process	replication fork processing
I	0031398	biological_process	positive regulation of protein ubiquitination
I	0036297	biological_process	interstrand cross-link repair
I	0043240	cellular_component	Fanconi anaemia nuclear complex
I	0051301	biological_process	cell division
I	0051382	biological_process	kinetochore assembly
I	0071821	cellular_component	FANCM-MHF complex
K	0046982	molecular_function	protein heterodimerization activity
K	0071821	cellular_component	FANCM-MHF complex
L	0000712	biological_process	resolution of meiotic recombination intermediates
L	0000775	cellular_component	chromosome, centromeric region
L	0000776	cellular_component	kinetochore
L	0000785	cellular_component	chromatin
L	0000939	cellular_component	inner kinetochore
L	0003677	molecular_function	DNA binding
L	0003690	molecular_function	double-stranded DNA binding
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005694	cellular_component	chromosome
L	0005829	cellular_component	cytosol
L	0006281	biological_process	DNA repair
L	0006974	biological_process	DNA damage response
L	0007049	biological_process	cell cycle
L	0007059	biological_process	chromosome segregation
L	0031297	biological_process	replication fork processing
L	0031398	biological_process	positive regulation of protein ubiquitination
L	0036297	biological_process	interstrand cross-link repair
L	0043240	cellular_component	Fanconi anaemia nuclear complex
L	0051301	biological_process	cell division
L	0051382	biological_process	kinetochore assembly
L	0071821	cellular_component	FANCM-MHF complex
M	0046982	molecular_function	protein heterodimerization activity
M	0071821	cellular_component	FANCM-MHF complex
N	0000712	biological_process	resolution of meiotic recombination intermediates
N	0000775	cellular_component	chromosome, centromeric region
N	0000776	cellular_component	kinetochore
N	0000785	cellular_component	chromatin
N	0000939	cellular_component	inner kinetochore
N	0003677	molecular_function	DNA binding
N	0003690	molecular_function	double-stranded DNA binding
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005694	cellular_component	chromosome
N	0005829	cellular_component	cytosol
N	0006281	biological_process	DNA repair
N	0006974	biological_process	DNA damage response
N	0007049	biological_process	cell cycle
N	0007059	biological_process	chromosome segregation
N	0031297	biological_process	replication fork processing
N	0031398	biological_process	positive regulation of protein ubiquitination
N	0036297	biological_process	interstrand cross-link repair
N	0043240	cellular_component	Fanconi anaemia nuclear complex
N	0051301	biological_process	cell division
N	0051382	biological_process	kinetochore assembly
N	0071821	cellular_component	FANCM-MHF complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE GOL B 101

Chain	Residue
B	ARG17

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 101

Chain	Residue
D	GLN76
D	ASP80
E	HIS751
E	CYS755

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site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL H 201

Chain	Residue
H	GLU32
H	PHE42
H	HOH320
J	LEU691

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN J 901

Chain	Residue
I	GLN76
I	ASP80
J	HIS751
J	CYS755

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN N 101

Chain	Residue
N	GLN76
N	ASP80
O	HIS751
O	CYS755

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22814378

Chain	Residue	Details
B	MET1
D	MET1
G	MET1
I	MET1
L	MET1
N	MET1

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