3OB2
Crystal structure of c-Cbl TKB domain in complex with double phosphorylated EGFR peptide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0001784 | molecular_function | phosphotyrosine residue binding |
| B | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0007166 | biological_process | cell surface receptor signaling pathway |
| B | 0023051 | biological_process | regulation of signaling |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL |
| Chain | Residue | Details |
| B | ASP229 | |
| B | THR231 | |
| B | ASN233 | |
| B | TYR235 | |
| B | GLU240 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| B | ARG294 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:3138233 |
| Chain | Residue | Details |
| A | SEP1070 | |
| A | SER1071 |
