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3OB2

Crystal structure of c-Cbl TKB domain in complex with double phosphorylated EGFR peptide

Summary for 3OB2
Entry DOI10.2210/pdb3ob2/pdb
Related3OB1
Descriptor12-meric peptide from Epidermal growth factor receptor, E3 ubiquitin-protein ligase CBL (3 entities in total)
Functional Keywordsprotein-peptide complex, double phosphorylation, ligase-signaling protein complex, ligase/signaling protein
Biological sourceHomo sapiens (human)
More
Cellular locationCell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
Cytoplasm: P22681
Total number of polymer chains2
Total formula weight39768.52
Authors
Sun, Q.,Sivaraman, J. (deposition date: 2010-08-06, release date: 2010-08-18, Last modification date: 2023-12-06)
Primary citationSun, Q.,Jackson, R.A.,Ng, C.,Guy, G.R.,Sivaraman, J.
Additional serine/threonine phosphorylation reduces binding affinity but preserves interface topography of substrate proteins to the c-Cbl TKB domain
Plos One, 5:e12819-e12819, 2010
Cited by
PubMed: 20877636
DOI: 10.1371/journal.pone.0012819
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

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