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3FCS

Structure of complete ectodomain of integrin aIIBb3

Functional Information from GO Data
ChainGOidnamespacecontents
A0001525biological_processangiogenesis
A0002687biological_processpositive regulation of leukocyte migration
A0005178molecular_functionintegrin binding
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0005925cellular_componentfocal adhesion
A0007155biological_processcell adhesion
A0007160biological_processcell-matrix adhesion
A0007229biological_processintegrin-mediated signaling pathway
A0008305cellular_componentintegrin complex
A0009897cellular_componentexternal side of plasma membrane
A0009986cellular_componentcell surface
A0016020cellular_componentmembrane
A0031092cellular_componentplatelet alpha granule membrane
A0033627biological_processcell adhesion mediated by integrin
A0042802molecular_functionidentical protein binding
A0046872molecular_functionmetal ion binding
A0050840molecular_functionextracellular matrix binding
A0060090molecular_functionmolecular adaptor activity
A0070051molecular_functionfibrinogen binding
A0070062cellular_componentextracellular exosome
A0072562cellular_componentblood microparticle
A0098609biological_processcell-cell adhesion
B0001618molecular_functionvirus receptor activity
B0001934biological_processpositive regulation of protein phosphorylation
B0001938biological_processpositive regulation of endothelial cell proliferation
B0001954biological_processpositive regulation of cell-matrix adhesion
B0001968molecular_functionfibronectin binding
B0002020molecular_functionprotease binding
B0002687biological_processpositive regulation of leukocyte migration
B0003756molecular_functionprotein disulfide isomerase activity
B0005080molecular_functionprotein kinase C binding
B0005161molecular_functionplatelet-derived growth factor receptor binding
B0005178molecular_functionintegrin binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005886cellular_componentplasma membrane
B0005911cellular_componentcell-cell junction
B0005925cellular_componentfocal adhesion
B0007044biological_processcell-substrate junction assembly
B0007155biological_processcell adhesion
B0007160biological_processcell-matrix adhesion
B0007229biological_processintegrin-mediated signaling pathway
B0007566biological_processembryo implantation
B0007596biological_processblood coagulation
B0008277biological_processregulation of G protein-coupled receptor signaling pathway
B0008305cellular_componentintegrin complex
B0009897cellular_componentexternal side of plasma membrane
B0009986cellular_componentcell surface
B0010595biological_processpositive regulation of endothelial cell migration
B0010628biological_processpositive regulation of gene expression
B0010745biological_processnegative regulation of macrophage derived foam cell differentiation
B0010763biological_processpositive regulation of fibroblast migration
B0010888biological_processnegative regulation of lipid storage
B0014823biological_processresponse to activity
B0014909biological_processsmooth muscle cell migration
B0014911biological_processpositive regulation of smooth muscle cell migration
B0015026molecular_functioncoreceptor activity
B0016020cellular_componentmembrane
B0016324cellular_componentapical plasma membrane
B0016477biological_processcell migration
B0017134molecular_functionfibroblast growth factor binding
B0019899molecular_functionenzyme binding
B0019960molecular_functionC-X3-C chemokine binding
B0030168biological_processplatelet activation
B0030335biological_processpositive regulation of cell migration
B0030949biological_processpositive regulation of vascular endothelial growth factor receptor signaling pathway
B0031092cellular_componentplatelet alpha granule membrane
B0031258cellular_componentlamellipodium membrane
B0031527cellular_componentfilopodium membrane
B0031528cellular_componentmicrovillus membrane
B0031589biological_processcell-substrate adhesion
B0031994molecular_functioninsulin-like growth factor I binding
B0032147biological_processactivation of protein kinase activity
B0032369biological_processnegative regulation of lipid transport
B0032587cellular_componentruffle membrane
B0032880biological_processregulation of protein localization
B0032956biological_processregulation of actin cytoskeleton organization
B0032991cellular_componentprotein-containing complex
B0033627biological_processcell adhesion mediated by integrin
B0033630biological_processpositive regulation of cell adhesion mediated by integrin
B0033690biological_processpositive regulation of osteoblast proliferation
B0034113biological_processheterotypic cell-cell adhesion
B0034446biological_processsubstrate adhesion-dependent cell spreading
B0034683cellular_componentintegrin alphav-beta3 complex
B0035295biological_processtube development
B0035313biological_processwound healing, spreading of epidermal cells
B0035866cellular_componentalphav-beta3 integrin-PKCalpha complex
B0035867cellular_componentalphav-beta3 integrin-IGF-1-IGF1R complex
B0035868cellular_componentalphav-beta3 integrin-HMGB1 complex
B0036119biological_processresponse to platelet-derived growth factor
B0036120biological_processcellular response to platelet-derived growth factor stimulus
B0038027biological_processapolipoprotein A-I-mediated signaling pathway
B0038132molecular_functionneuregulin binding
B0042060biological_processwound healing
B0042470cellular_componentmelanosome
B0042802molecular_functionidentical protein binding
B0042995cellular_componentcell projection
B0043184molecular_functionvascular endothelial growth factor receptor 2 binding
B0043235cellular_componentreceptor complex
B0043277biological_processapoptotic cell clearance
B0045124biological_processregulation of bone resorption
B0045202cellular_componentsynapse
B0045211cellular_componentpostsynaptic membrane
B0045766biological_processpositive regulation of angiogenesis
B0045780biological_processpositive regulation of bone resorption
B0046718biological_processsymbiont entry into host cell
B0046872molecular_functionmetal ion binding
B0048008biological_processplatelet-derived growth factor receptor signaling pathway
B0048146biological_processpositive regulation of fibroblast proliferation
B0048333biological_processmesodermal cell differentiation
B0048661biological_processpositive regulation of smooth muscle cell proliferation
B0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
B0050748biological_processnegative regulation of lipoprotein metabolic process
B0050839molecular_functioncell adhesion molecule binding
B0050840molecular_functionextracellular matrix binding
B0050919biological_processnegative chemotaxis
B0051279biological_processregulation of release of sequestered calcium ion into cytosol
B0051611biological_processregulation of serotonin uptake
B0060055biological_processangiogenesis involved in wound healing
B0070051molecular_functionfibrinogen binding
B0070062cellular_componentextracellular exosome
B0070161cellular_componentanchoring junction
B0070374biological_processpositive regulation of ERK1 and ERK2 cascade
B0070527biological_processplatelet aggregation
B0071062cellular_componentalphav-beta3 integrin-vitronectin complex
B0071133cellular_componentalpha9-beta1 integrin-ADAM8 complex
B0071260biological_processcellular response to mechanical stimulus
B0071466biological_processcellular response to xenobiotic stimulus
B0072126biological_processpositive regulation of glomerular mesangial cell proliferation
B0072378biological_processblood coagulation, fibrin clot formation
B0097060cellular_componentsynaptic membrane
B0098690cellular_componentglycinergic synapse
B0098880biological_processmaintenance of postsynaptic specialization structure
B0098978cellular_componentglutamatergic synapse
B0099149biological_processregulation of postsynaptic neurotransmitter receptor internalization
B0150054biological_processregulation of postsynaptic neurotransmitter receptor diffusion trapping
B1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
B1900731biological_processpositive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway
B1901163biological_processregulation of trophoblast cell migration
B1903053biological_processregulation of extracellular matrix organization
B1905598biological_processnegative regulation of low-density lipoprotein receptor activity
B1990314biological_processcellular response to insulin-like growth factor stimulus
B2000352biological_processnegative regulation of endothelial cell apoptotic process
B2000406biological_processpositive regulation of T cell migration
C0001525biological_processangiogenesis
C0002687biological_processpositive regulation of leukocyte migration
C0005178molecular_functionintegrin binding
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0005925cellular_componentfocal adhesion
C0007155biological_processcell adhesion
C0007160biological_processcell-matrix adhesion
C0007229biological_processintegrin-mediated signaling pathway
C0008305cellular_componentintegrin complex
C0009897cellular_componentexternal side of plasma membrane
C0009986cellular_componentcell surface
C0016020cellular_componentmembrane
C0031092cellular_componentplatelet alpha granule membrane
C0033627biological_processcell adhesion mediated by integrin
C0042802molecular_functionidentical protein binding
C0046872molecular_functionmetal ion binding
C0050840molecular_functionextracellular matrix binding
C0060090molecular_functionmolecular adaptor activity
C0070051molecular_functionfibrinogen binding
C0070062cellular_componentextracellular exosome
C0072562cellular_componentblood microparticle
C0098609biological_processcell-cell adhesion
D0001618molecular_functionvirus receptor activity
D0001934biological_processpositive regulation of protein phosphorylation
D0001938biological_processpositive regulation of endothelial cell proliferation
D0001954biological_processpositive regulation of cell-matrix adhesion
D0001968molecular_functionfibronectin binding
D0002020molecular_functionprotease binding
D0002687biological_processpositive regulation of leukocyte migration
D0003756molecular_functionprotein disulfide isomerase activity
D0005080molecular_functionprotein kinase C binding
D0005161molecular_functionplatelet-derived growth factor receptor binding
D0005178molecular_functionintegrin binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005886cellular_componentplasma membrane
D0005911cellular_componentcell-cell junction
D0005925cellular_componentfocal adhesion
D0007044biological_processcell-substrate junction assembly
D0007155biological_processcell adhesion
D0007160biological_processcell-matrix adhesion
D0007229biological_processintegrin-mediated signaling pathway
D0007566biological_processembryo implantation
D0007596biological_processblood coagulation
D0008277biological_processregulation of G protein-coupled receptor signaling pathway
D0008305cellular_componentintegrin complex
D0009897cellular_componentexternal side of plasma membrane
D0009986cellular_componentcell surface
D0010595biological_processpositive regulation of endothelial cell migration
D0010628biological_processpositive regulation of gene expression
D0010745biological_processnegative regulation of macrophage derived foam cell differentiation
D0010763biological_processpositive regulation of fibroblast migration
D0010888biological_processnegative regulation of lipid storage
D0014823biological_processresponse to activity
D0014909biological_processsmooth muscle cell migration
D0014911biological_processpositive regulation of smooth muscle cell migration
D0015026molecular_functioncoreceptor activity
D0016020cellular_componentmembrane
D0016324cellular_componentapical plasma membrane
D0016477biological_processcell migration
D0017134molecular_functionfibroblast growth factor binding
D0019899molecular_functionenzyme binding
D0019960molecular_functionC-X3-C chemokine binding
D0030168biological_processplatelet activation
D0030335biological_processpositive regulation of cell migration
D0030949biological_processpositive regulation of vascular endothelial growth factor receptor signaling pathway
D0031092cellular_componentplatelet alpha granule membrane
D0031258cellular_componentlamellipodium membrane
D0031527cellular_componentfilopodium membrane
D0031528cellular_componentmicrovillus membrane
D0031589biological_processcell-substrate adhesion
D0031994molecular_functioninsulin-like growth factor I binding
D0032147biological_processactivation of protein kinase activity
D0032369biological_processnegative regulation of lipid transport
D0032587cellular_componentruffle membrane
D0032880biological_processregulation of protein localization
D0032956biological_processregulation of actin cytoskeleton organization
D0032991cellular_componentprotein-containing complex
D0033627biological_processcell adhesion mediated by integrin
D0033630biological_processpositive regulation of cell adhesion mediated by integrin
D0033690biological_processpositive regulation of osteoblast proliferation
D0034113biological_processheterotypic cell-cell adhesion
D0034446biological_processsubstrate adhesion-dependent cell spreading
D0034683cellular_componentintegrin alphav-beta3 complex
D0035295biological_processtube development
D0035313biological_processwound healing, spreading of epidermal cells
D0035866cellular_componentalphav-beta3 integrin-PKCalpha complex
D0035867cellular_componentalphav-beta3 integrin-IGF-1-IGF1R complex
D0035868cellular_componentalphav-beta3 integrin-HMGB1 complex
D0036119biological_processresponse to platelet-derived growth factor
D0036120biological_processcellular response to platelet-derived growth factor stimulus
D0038027biological_processapolipoprotein A-I-mediated signaling pathway
D0038132molecular_functionneuregulin binding
D0042060biological_processwound healing
D0042470cellular_componentmelanosome
D0042802molecular_functionidentical protein binding
D0042995cellular_componentcell projection
D0043184molecular_functionvascular endothelial growth factor receptor 2 binding
D0043235cellular_componentreceptor complex
D0043277biological_processapoptotic cell clearance
D0045124biological_processregulation of bone resorption
D0045202cellular_componentsynapse
D0045211cellular_componentpostsynaptic membrane
D0045766biological_processpositive regulation of angiogenesis
D0045780biological_processpositive regulation of bone resorption
D0046718biological_processsymbiont entry into host cell
D0046872molecular_functionmetal ion binding
D0048008biological_processplatelet-derived growth factor receptor signaling pathway
D0048146biological_processpositive regulation of fibroblast proliferation
D0048333biological_processmesodermal cell differentiation
D0048661biological_processpositive regulation of smooth muscle cell proliferation
D0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
D0050748biological_processnegative regulation of lipoprotein metabolic process
D0050839molecular_functioncell adhesion molecule binding
D0050840molecular_functionextracellular matrix binding
D0050919biological_processnegative chemotaxis
D0051279biological_processregulation of release of sequestered calcium ion into cytosol
D0051611biological_processregulation of serotonin uptake
D0060055biological_processangiogenesis involved in wound healing
D0070051molecular_functionfibrinogen binding
D0070062cellular_componentextracellular exosome
D0070161cellular_componentanchoring junction
D0070374biological_processpositive regulation of ERK1 and ERK2 cascade
D0070527biological_processplatelet aggregation
D0071062cellular_componentalphav-beta3 integrin-vitronectin complex
D0071133cellular_componentalpha9-beta1 integrin-ADAM8 complex
D0071260biological_processcellular response to mechanical stimulus
D0071466biological_processcellular response to xenobiotic stimulus
D0072126biological_processpositive regulation of glomerular mesangial cell proliferation
D0072378biological_processblood coagulation, fibrin clot formation
D0097060cellular_componentsynaptic membrane
D0098690cellular_componentglycinergic synapse
D0098880biological_processmaintenance of postsynaptic specialization structure
D0098978cellular_componentglutamatergic synapse
D0099149biological_processregulation of postsynaptic neurotransmitter receptor internalization
D0150054biological_processregulation of postsynaptic neurotransmitter receptor diffusion trapping
D1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
D1900731biological_processpositive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway
D1901163biological_processregulation of trophoblast cell migration
D1903053biological_processregulation of extracellular matrix organization
D1905598biological_processnegative regulation of low-density lipoprotein receptor activity
D1990314biological_processcellular response to insulin-like growth factor stimulus
D2000352biological_processnegative regulation of endothelial cell apoptotic process
D2000406biological_processpositive regulation of T cell migration
Functional Information from PROSITE/UniProt
site_idPS01186
Number of Residues14
DetailsEGF_2 EGF-like domain signature 2. CrCgpGWlgsqce..C
ChainResidueDetails
BCYS460-CYS473

site_idPS00022
Number of Residues12
DetailsEGF_1 EGF-like domain signature 1. CrCgpGwlGSqC
ChainResidueDetails
BCYS460-CYS471
BCYS547-CYS558

site_idPS00243
Number of Residues14
DetailsINTEGRIN_BETA Integrins beta chain cysteine-rich domain signature. CsQr..GeClCgqCvC
ChainResidueDetails
BCYS495-CYS508
BCYS536-CYS549
BCYS575-CYS588

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING: in MIDAS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU
ChainResidueDetails
BSER121
AASP305
AASP365
AASP367
AASP369
ATYR371
AASP373
AASP426
AASP428
AASN430
ATYR432
BGLU220
AASP434
CGLU243
CASP245
CASP247
CTHR250
CGLU252
CASP297
CASN299
CASP301
CARG303
DSER121
CASP305
CASP365
CASP367
CASP369
CTYR371
CASP373
CASP426
CASP428
CASN430
CTYR432
DGLU220
CASP434
AGLU252
AASP297
AASN299
AASP301
AARG303

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: in MIDAS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCU
ChainResidueDetails
BSER123
DSER123

site_idSWS_FT_FI3
Number of Residues4
DetailsBINDING: in ADMIDAS binding site => ECO:0000269|PubMed:11546839, ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1JV2, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU, ECO:0007744|PDB:3IJE
ChainResidueDetails
BASP126
BASP127
DASP126
DASP127

site_idSWS_FT_FI4
Number of Residues8
DetailsBINDING: in LIMBS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU
ChainResidueDetails
BASP158
BASN215
BASP217
BPRO219
DASP158
DASN215
DASP217
DPRO219

site_idSWS_FT_FI5
Number of Residues2
DetailsBINDING: in LIMBS binding site => ECO:0007744|PDB:4G1M
ChainResidueDetails
BASP251
DASP251

site_idSWS_FT_FI6
Number of Residues2
DetailsBINDING: in ADMIDAS binding site and unliganded-closed conformation => ECO:0000269|PubMed:11546839, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1JV2, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3IJE
ChainResidueDetails
BMET335
DMET335

site_idSWS_FT_FI7
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:16263699, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3IJE
ChainResidueDetails
BASN99
DASN99

site_idSWS_FT_FI8
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11546839, ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1JV2, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3IJE
ChainResidueDetails
BASN320
BASN371
DASN320
DASN371

site_idSWS_FT_FI9
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:3IJE
ChainResidueDetails
BASN452
DASN452

site_idSWS_FT_FI10
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11546839, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1JV2, ECO:0007744|PDB:3IJE
ChainResidueDetails
BASN559
DASN559

site_idSWS_FT_FI11
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11546839, ECO:0000269|PubMed:19159218, ECO:0007744|PDB:1JV2
ChainResidueDetails
BASN654
DASN654

218853

PDB entries from 2024-04-24

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