Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3ENZ

Arsenolytic structure of Plasmodium falciparum purine nucleoside phosphorylase with hypoxanthine, ribose and arsenate ion

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004731	molecular_function	purine-nucleoside phosphorylase activity
A	0004850	molecular_function	uridine phosphorylase activity
A	0005829	cellular_component	cytosol
A	0006148	biological_process	inosine catabolic process
A	0006166	biological_process	purine ribonucleoside salvage
A	0006195	biological_process	purine nucleotide catabolic process
A	0006218	biological_process	uridine catabolic process
A	0009116	biological_process	nucleoside metabolic process
A	0016757	molecular_function	glycosyltransferase activity
A	0017061	molecular_function	S-methyl-5-thioadenosine phosphorylase activity
A	0047975	molecular_function	guanosine phosphorylase activity
B	0003824	molecular_function	catalytic activity
B	0004731	molecular_function	purine-nucleoside phosphorylase activity
B	0004850	molecular_function	uridine phosphorylase activity
B	0005829	cellular_component	cytosol
B	0006148	biological_process	inosine catabolic process
B	0006166	biological_process	purine ribonucleoside salvage
B	0006195	biological_process	purine nucleotide catabolic process
B	0006218	biological_process	uridine catabolic process
B	0009116	biological_process	nucleoside metabolic process
B	0016757	molecular_function	glycosyltransferase activity
B	0017061	molecular_function	S-methyl-5-thioadenosine phosphorylase activity
B	0047975	molecular_function	guanosine phosphorylase activity
C	0003824	molecular_function	catalytic activity
C	0004731	molecular_function	purine-nucleoside phosphorylase activity
C	0004850	molecular_function	uridine phosphorylase activity
C	0005829	cellular_component	cytosol
C	0006148	biological_process	inosine catabolic process
C	0006166	biological_process	purine ribonucleoside salvage
C	0006195	biological_process	purine nucleotide catabolic process
C	0006218	biological_process	uridine catabolic process
C	0009116	biological_process	nucleoside metabolic process
C	0016757	molecular_function	glycosyltransferase activity
C	0017061	molecular_function	S-methyl-5-thioadenosine phosphorylase activity
C	0047975	molecular_function	guanosine phosphorylase activity
D	0003824	molecular_function	catalytic activity
D	0004731	molecular_function	purine-nucleoside phosphorylase activity
D	0004850	molecular_function	uridine phosphorylase activity
D	0005829	cellular_component	cytosol
D	0006148	biological_process	inosine catabolic process
D	0006166	biological_process	purine ribonucleoside salvage
D	0006195	biological_process	purine nucleotide catabolic process
D	0006218	biological_process	uridine catabolic process
D	0009116	biological_process	nucleoside metabolic process
D	0016757	molecular_function	glycosyltransferase activity
D	0017061	molecular_function	S-methyl-5-thioadenosine phosphorylase activity
D	0047975	molecular_function	guanosine phosphorylase activity
E	0003824	molecular_function	catalytic activity
E	0004731	molecular_function	purine-nucleoside phosphorylase activity
E	0004850	molecular_function	uridine phosphorylase activity
E	0005829	cellular_component	cytosol
E	0006148	biological_process	inosine catabolic process
E	0006166	biological_process	purine ribonucleoside salvage
E	0006195	biological_process	purine nucleotide catabolic process
E	0006218	biological_process	uridine catabolic process
E	0009116	biological_process	nucleoside metabolic process
E	0016757	molecular_function	glycosyltransferase activity
E	0017061	molecular_function	S-methyl-5-thioadenosine phosphorylase activity
E	0047975	molecular_function	guanosine phosphorylase activity
F	0003824	molecular_function	catalytic activity
F	0004731	molecular_function	purine-nucleoside phosphorylase activity
F	0004850	molecular_function	uridine phosphorylase activity
F	0005829	cellular_component	cytosol
F	0006148	biological_process	inosine catabolic process
F	0006166	biological_process	purine ribonucleoside salvage
F	0006195	biological_process	purine nucleotide catabolic process
F	0006218	biological_process	uridine catabolic process
F	0009116	biological_process	nucleoside metabolic process
F	0016757	molecular_function	glycosyltransferase activity
F	0017061	molecular_function	S-methyl-5-thioadenosine phosphorylase activity
F	0047975	molecular_function	guanosine phosphorylase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: Proton donor => ECO:0000305\|PubMed:24416224

Chain	Residue	Details
A	ASP206
B	ASP206
C	ASP206
D	ASP206
E	ASP206
F	ASP206

site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000305\|PubMed:24416224, ECO:0000305\|Ref.7, ECO:0007744\|PDB:3FOW, ECO:0007744\|PDB:3PHC

Chain	Residue	Details
A	HIS7
B	HIS7
C	HIS7
D	HIS7
E	HIS7
F	HIS7

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: in other chain => ECO:0000269\|PubMed:24416224, ECO:0000269\|Ref.7, ECO:0000305\|PubMed:14982926, ECO:0000305\|PubMed:19575810, ECO:0007744\|PDB:1NW4, ECO:0007744\|PDB:1Q1G, ECO:0007744\|PDB:3ENZ, ECO:0007744\|PDB:3FOW, ECO:0007744\|PDB:3PHC

Chain	Residue	Details
A	GLY23
B	GLY23
C	GLY23
D	GLY23
E	GLY23
F	GLY23

site_id	SWS_FT_FI4
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269\|PubMed:24416224, ECO:0000269\|Ref.7, ECO:0000305\|PubMed:14982926, ECO:0000305\|PubMed:19575810, ECO:0007744\|PDB:1NW4, ECO:0007744\|PDB:1Q1G, ECO:0007744\|PDB:3ENZ, ECO:0007744\|PDB:3FOW, ECO:0007744\|PDB:3PHC

Chain	Residue	Details
A	ARG45
B	ARG45
C	ARG45
D	ARG45
E	ARG45
F	ARG45

site_id	SWS_FT_FI5
Number of Residues	6
Details	BINDING: in other chain => ECO:0000269\|PubMed:24416224, ECO:0000269\|PubMed:29440412, ECO:0000269\|Ref.7, ECO:0000305\|PubMed:14982926, ECO:0000305\|PubMed:19575810, ECO:0007744\|PDB:1NW4, ECO:0007744\|PDB:1Q1G, ECO:0007744\|PDB:3ENZ, ECO:0007744\|PDB:3FOW, ECO:0007744\|PDB:3PHC, ECO:0007744\|PDB:6AQS, ECO:0007744\|PDB:6AQU

Chain	Residue	Details
A	ARG88
B	ARG88
C	ARG88
D	ARG88
E	ARG88
F	ARG88

site_id	SWS_FT_FI6
Number of Residues	6
Details	BINDING: in other chain => ECO:0000269\|PubMed:16131758, ECO:0000305\|PubMed:24416224, ECO:0000305\|Ref.7, ECO:0007744\|PDB:2BSX, ECO:0007744\|PDB:3FOW, ECO:0007744\|PDB:3PHC

Chain	Residue	Details
A	MET183
B	MET183
C	MET183
D	MET183
E	MET183
F	MET183

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	4
Details	M-CSA 695

Chain	Residue	Details
A	ARG27	electrostatic stabiliser
A	ARG45	electrostatic stabiliser
A	ARG88	electrostatic stabiliser
A	ASP206	proton acceptor, proton donor

site_id	MCSA2
Number of Residues	4
Details	M-CSA 695

Chain	Residue	Details
B	ARG27	electrostatic stabiliser
B	ARG45	electrostatic stabiliser
B	ARG88	electrostatic stabiliser
B	ASP206	proton acceptor, proton donor

site_id	MCSA3
Number of Residues	4
Details	M-CSA 695

Chain	Residue	Details
C	ARG27	electrostatic stabiliser
C	ARG45	electrostatic stabiliser
C	ARG88	electrostatic stabiliser
C	ASP206	proton acceptor, proton donor

site_id	MCSA4
Number of Residues	4
Details	M-CSA 695

Chain	Residue	Details
D	ARG27	electrostatic stabiliser
D	ARG45	electrostatic stabiliser
D	ARG88	electrostatic stabiliser
D	ASP206	proton acceptor, proton donor

site_id	MCSA5
Number of Residues	4
Details	M-CSA 695

Chain	Residue	Details
E	ARG27	electrostatic stabiliser
E	ARG45	electrostatic stabiliser
E	ARG88	electrostatic stabiliser
E	ASP206	proton acceptor, proton donor

site_id	MCSA6
Number of Residues	4
Details	M-CSA 695

Chain	Residue	Details
F	ARG27	electrostatic stabiliser
F	ARG45	electrostatic stabiliser
F	ARG88	electrostatic stabiliser
F	ASP206	proton acceptor, proton donor

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)