6AQU
Crystal Structure of Plasmodium falciparum purine nucleoside phosphorylase: The M183L mutant
Summary for 6AQU
| Entry DOI | 10.2210/pdb6aqu/pdb |
| Descriptor | Purine nucleoside phosphorylase, PHOSPHATE ION (3 entities in total) |
| Functional Keywords | plasmodium falciparum, purine nucleoside phosphorylase (pnp), pnp mutation, drug resistant pnp., transferase |
| Biological source | Plasmodium falciparum |
| Total number of polymer chains | 2 |
| Total formula weight | 54319.42 |
| Authors | Harijan, R.K.,Ducati, R.G.,Namanja-Magliano, H.A.,Bonanno, J.B.,Almo, S.C.,Schramm, V.L. (deposition date: 2017-08-21, release date: 2018-03-28, Last modification date: 2023-10-04) |
| Primary citation | Ducati, R.G.,Namanja-Magliano, H.A.,Harijan, R.K.,Fajardo, J.E.,Fiser, A.,Daily, J.P.,Schramm, V.L. Genetic resistance to purine nucleoside phosphorylase inhibition inPlasmodium falciparum. Proc. Natl. Acad. Sci. U.S.A., 115:2114-2119, 2018 Cited by PubMed: 29440412DOI: 10.1073/pnas.1525670115 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
Download full validation report
