3DXD
Crystal structure of the intracellular domain of human APP (T668E mutant) in complex with Fe65-PTB2
Functional Information from GO Data
Functional Information from PROSITE/UniProt
| site_id | PS00320 |
| Number of Residues | 8 |
| Details | APP_INTRA Amyloid precursor protein (APP) intracellular domain signature. GYENPTYK |
| Chain | Residue | Details |
| B | GLY681-LYS688 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by caspase-6, caspase-8 or caspase-9 => ECO:0000269|PubMed:10319819 |
| Chain | Residue | Details |
| B | ASP664 | |
| D | ASP664 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by CDK5 and MAPK10 => ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:8131745, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| B | GLU668 | |
| D | GLU668 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:11877420 |
| Chain | Residue | Details |
| B | TYR682 | |
| D | TYR682 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P08592 |
| Chain | Residue | Details |
| B | LYS688 | |
| D | LYS688 |
