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3DXD

Crystal structure of the intracellular domain of human APP (T668E mutant) in complex with Fe65-PTB2

Summary for 3DXD
Entry DOI10.2210/pdb3dxd/pdb
Related3DXC 3DXE
DescriptorAmyloid beta A4 protein-binding family B member 1, Amyloid beta A4 protein (3 entities in total)
Functional Keywordsalzheimer's disease, app, aicd, fe65, ptb domain, alzheimer disease, amyloid, apoptosis, cell adhesion, coated pit, disease mutation, endocytosis, glycoprotein, heparin-binding, iron, membrane, metal-binding, notch signaling pathway, phosphoprotein, protease inhibitor, proteoglycan, serine protease inhibitor, transmembrane, protein binding
Biological sourceHomo sapiens (Human)
More
Cellular locationCell membrane: O00213
Membrane; Single-pass type I membrane protein: P05067
Total number of polymer chains4
Total formula weight39166.41
Authors
Radzimanowski, J.,Sinning, I.,Wild, K. (deposition date: 2008-07-24, release date: 2008-09-16, Last modification date: 2024-02-21)
Primary citationRadzimanowski, J.,Simon, B.,Sattler, M.,Beyreuther, K.,Sinning, I.,Wild, K.
Structure of the intracellular domain of the amyloid precursor protein in complex with Fe65-PTB2.
Embo Rep., 9:1134-1140, 2008
Cited by
PubMed: 18833287
DOI: 10.1038/embor.2008.188
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

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