2ODE
Crystal structure of the heterodimeric complex of human RGS8 and activated Gi alpha 3
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000139 | cellular_component | Golgi membrane |
| A | 0001664 | molecular_function | G protein-coupled receptor binding |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005730 | cellular_component | nucleolus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005765 | cellular_component | lysosomal membrane |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005813 | cellular_component | centrosome |
| A | 0005834 | cellular_component | heterotrimeric G-protein complex |
| A | 0005856 | cellular_component | cytoskeleton |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007165 | biological_process | signal transduction |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0007188 | biological_process | adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| A | 0007193 | biological_process | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
| A | 0007194 | biological_process | negative regulation of adenylate cyclase activity |
| A | 0007212 | biological_process | dopamine receptor signaling pathway |
| A | 0016020 | cellular_component | membrane |
| A | 0016239 | biological_process | positive regulation of macroautophagy |
| A | 0019001 | molecular_function | guanyl nucleotide binding |
| A | 0019003 | molecular_function | GDP binding |
| A | 0030496 | cellular_component | midbody |
| A | 0031683 | molecular_function | G-protein beta/gamma-subunit complex binding |
| A | 0046039 | biological_process | GTP metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051301 | biological_process | cell division |
| A | 0070062 | cellular_component | extracellular exosome |
| C | 0000139 | cellular_component | Golgi membrane |
| C | 0001664 | molecular_function | G protein-coupled receptor binding |
| C | 0003924 | molecular_function | GTPase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005525 | molecular_function | GTP binding |
| C | 0005654 | cellular_component | nucleoplasm |
| C | 0005730 | cellular_component | nucleolus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005765 | cellular_component | lysosomal membrane |
| C | 0005789 | cellular_component | endoplasmic reticulum membrane |
| C | 0005794 | cellular_component | Golgi apparatus |
| C | 0005813 | cellular_component | centrosome |
| C | 0005834 | cellular_component | heterotrimeric G-protein complex |
| C | 0005856 | cellular_component | cytoskeleton |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0007165 | biological_process | signal transduction |
| C | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| C | 0007188 | biological_process | adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| C | 0007193 | biological_process | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
| C | 0007194 | biological_process | negative regulation of adenylate cyclase activity |
| C | 0007212 | biological_process | dopamine receptor signaling pathway |
| C | 0016020 | cellular_component | membrane |
| C | 0016239 | biological_process | positive regulation of macroautophagy |
| C | 0019001 | molecular_function | guanyl nucleotide binding |
| C | 0019003 | molecular_function | GDP binding |
| C | 0030496 | cellular_component | midbody |
| C | 0031683 | molecular_function | G-protein beta/gamma-subunit complex binding |
| C | 0046039 | biological_process | GTP metabolic process |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0051301 | biological_process | cell division |
| C | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE ALF A 2001 |
| Chain | Residue |
| A | GLY42 |
| A | MG3001 |
| A | HOH3229 |
| A | HOH3231 |
| A | HOH3236 |
| A | GLU43 |
| A | LYS46 |
| A | ARG178 |
| A | LYS180 |
| A | THR181 |
| A | GLY203 |
| A | GLN204 |
| A | GDP1001 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE ALF C 2002 |
| Chain | Residue |
| C | GLY42 |
| C | GLU43 |
| C | LYS46 |
| C | ARG178 |
| C | LYS180 |
| C | THR181 |
| C | VAL201 |
| C | GLY203 |
| C | GLN204 |
| C | GDP1002 |
| C | MG3002 |
| C | HOH3187 |
| C | HOH3190 |
| C | HOH3194 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 3001 |
| Chain | Residue |
| A | SER47 |
| A | THR181 |
| A | GDP1001 |
| A | ALF2001 |
| A | HOH3229 |
| A | HOH3231 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG C 3002 |
| Chain | Residue |
| C | SER47 |
| C | THR181 |
| C | GDP1002 |
| C | ALF2002 |
| C | HOH3187 |
| C | HOH3190 |
| site_id | AC5 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE GDP A 1001 |
| Chain | Residue |
| A | GLU43 |
| A | SER44 |
| A | GLY45 |
| A | LYS46 |
| A | SER47 |
| A | THR48 |
| A | SER151 |
| A | LEU175 |
| A | ARG176 |
| A | THR177 |
| A | ARG178 |
| A | ASN269 |
| A | LYS270 |
| A | ASP272 |
| A | LEU273 |
| A | CYS325 |
| A | ALA326 |
| A | THR327 |
| A | ALF2001 |
| A | MG3001 |
| A | HOH3002 |
| A | HOH3007 |
| A | HOH3012 |
| A | HOH3229 |
| A | HOH3231 |
| site_id | AC6 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE GDP C 1002 |
| Chain | Residue |
| C | GLU43 |
| C | SER44 |
| C | GLY45 |
| C | LYS46 |
| C | SER47 |
| C | THR48 |
| C | SER151 |
| C | LEU175 |
| C | ARG176 |
| C | THR177 |
| C | ARG178 |
| C | ASN269 |
| C | LYS270 |
| C | ASP272 |
| C | LEU273 |
| C | CYS325 |
| C | ALA326 |
| C | THR327 |
| C | ALF2002 |
| C | MG3002 |
| C | HOH3007 |
| C | HOH3008 |
| C | HOH3018 |
| C | HOH3187 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0007744|PDB:2IHB, ECO:0007744|PDB:2ODE, ECO:0007744|PDB:2V4Z, ECO:0007744|PDB:4G5O, ECO:0007744|PDB:4G5R, ECO:0007744|PDB:4G5S |
| Chain | Residue | Details |
| A | GLU43 | |
| A | LEU175 | |
| A | ASN269 | |
| C | GLU43 | |
| C | LEU175 | |
| C | ASN269 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:19478087, ECO:0007744|PDB:2V4Z |
| Chain | Residue | Details |
| A | SER47 | |
| A | THR181 | |
| C | SER47 | |
| C | THR181 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0007744|PDB:2V4Z, ECO:0007744|PDB:4G5O, ECO:0007744|PDB:4G5R, ECO:0007744|PDB:4G5S |
| Chain | Residue | Details |
| A | ASP150 | |
| C | ASP150 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:19478087, ECO:0007744|PDB:2V4Z |
| Chain | Residue | Details |
| A | ASP200 | |
| C | ASP200 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0007744|PDB:2IHB, ECO:0007744|PDB:2ODE, ECO:0007744|PDB:2V4Z, ECO:0007744|PDB:4G5O, ECO:0007744|PDB:4G5R |
| Chain | Residue | Details |
| A | ALA326 | |
| C | ALA326 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: ADP-ribosylarginine; by cholera toxin => ECO:0000250 |
| Chain | Residue | Details |
| A | ARG178 | |
| C | ARG178 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Deamidated glutamine; by Photorhabdus PAU_02230 => ECO:0000269|PubMed:24141704 |
| Chain | Residue | Details |
| A | GLN204 | |
| C | GLN204 |
