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1TND

THE 2.2 ANGSTROMS CRYSTAL STRUCTURE OF TRANSDUCIN-ALPHA COMPLEXED WITH GTP GAMMA S

Functional Information from GO Data
ChainGOidnamespacecontents
A0000035molecular_functionacyl binding
A0001664molecular_functionG protein-coupled receptor binding
A0001750cellular_componentphotoreceptor outer segment
A0001917cellular_componentphotoreceptor inner segment
A0003924molecular_functionGTPase activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005834cellular_componentheterotrimeric G-protein complex
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
A0007601biological_processvisual perception
A0007602biological_processphototransduction
A0007603biological_processphototransduction, visible light
A0009416biological_processresponse to light stimulus
A0016020cellular_componentmembrane
A0019001molecular_functionguanyl nucleotide binding
A0019003molecular_functionGDP binding
A0019901molecular_functionprotein kinase binding
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
A0042622cellular_componentphotoreceptor outer segment membrane
A0042995cellular_componentcell projection
A0046872molecular_functionmetal ion binding
A0050908biological_processdetection of light stimulus involved in visual perception
A0051344biological_processnegative regulation of cyclic-nucleotide phosphodiesterase activity
A0097381cellular_componentphotoreceptor disc membrane
A0097648cellular_componentG protein-coupled receptor complex
B0000035molecular_functionacyl binding
B0001664molecular_functionG protein-coupled receptor binding
B0001750cellular_componentphotoreceptor outer segment
B0001917cellular_componentphotoreceptor inner segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005737cellular_componentcytoplasm
B0005834cellular_componentheterotrimeric G-protein complex
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
B0007601biological_processvisual perception
B0007602biological_processphototransduction
B0007603biological_processphototransduction, visible light
B0009416biological_processresponse to light stimulus
B0016020cellular_componentmembrane
B0019001molecular_functionguanyl nucleotide binding
B0019003molecular_functionGDP binding
B0019901molecular_functionprotein kinase binding
B0031683molecular_functionG-protein beta/gamma-subunit complex binding
B0042622cellular_componentphotoreceptor outer segment membrane
B0042995cellular_componentcell projection
B0046872molecular_functionmetal ion binding
B0050908biological_processdetection of light stimulus involved in visual perception
B0051344biological_processnegative regulation of cyclic-nucleotide phosphodiesterase activity
B0097381cellular_componentphotoreceptor disc membrane
B0097648cellular_componentG protein-coupled receptor complex
C0000035molecular_functionacyl binding
C0001664molecular_functionG protein-coupled receptor binding
C0001750cellular_componentphotoreceptor outer segment
C0001917cellular_componentphotoreceptor inner segment
C0003924molecular_functionGTPase activity
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005737cellular_componentcytoplasm
C0005834cellular_componentheterotrimeric G-protein complex
C0007165biological_processsignal transduction
C0007186biological_processG protein-coupled receptor signaling pathway
C0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
C0007601biological_processvisual perception
C0007602biological_processphototransduction
C0007603biological_processphototransduction, visible light
C0009416biological_processresponse to light stimulus
C0016020cellular_componentmembrane
C0019001molecular_functionguanyl nucleotide binding
C0019003molecular_functionGDP binding
C0019901molecular_functionprotein kinase binding
C0031683molecular_functionG-protein beta/gamma-subunit complex binding
C0042622cellular_componentphotoreceptor outer segment membrane
C0042995cellular_componentcell projection
C0046872molecular_functionmetal ion binding
C0050908biological_processdetection of light stimulus involved in visual perception
C0051344biological_processnegative regulation of cyclic-nucleotide phosphodiesterase activity
C0097381cellular_componentphotoreceptor disc membrane
C0097648cellular_componentG protein-coupled receptor complex
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A 352
ChainResidue
ASER43
ATHR177
AGSP351
AHOH359
AHOH361

site_idAC2
Number of Residues1
DetailsBINDING SITE FOR RESIDUE CAC A 353
ChainResidue
ACYS62

site_idAC3
Number of Residues1
DetailsBINDING SITE FOR RESIDUE CAC A 354
ChainResidue
ACYS210

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG B 352
ChainResidue
BGSP351
BHOH372
BHOH379
BSER43
BTHR177

site_idAC5
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CAC B 353
ChainResidue
BCYS62
BPRO165

site_idAC6
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CAC B 354
ChainResidue
BCYS210
BHOH432

site_idAC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG C 352
ChainResidue
CSER43
CTHR177
CGSP351
CHOH382
CHOH383

site_idAC8
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CAC C 353
ChainResidue
CCYS62
CPRO165

site_idAC9
Number of Residues1
DetailsBINDING SITE FOR RESIDUE CAC C 354
ChainResidue
CCYS210

site_idBC1
Number of Residues29
DetailsBINDING SITE FOR RESIDUE GSP A 351
ChainResidue
AGLU39
ASER40
AGLY41
ALYS42
ASER43
ATHR44
AASP146
ASER147
ALEU171
AARG172
ASER173
AARG174
ATHR177
AGLY198
AGLY199
AASN265
ALYS266
AASP268
AVAL269
ACYS321
AALA322
ATHR323
AMG352
AHOH359
AHOH361
AHOH365
AHOH412
AHOH414
AHOH416

site_idBC2
Number of Residues28
DetailsBINDING SITE FOR RESIDUE GSP B 351
ChainResidue
BGLY38
BGLU39
BSER40
BGLY41
BLYS42
BSER43
BTHR44
BASP146
BLEU171
BARG172
BSER173
BARG174
BTHR177
BGLY198
BGLY199
BASN265
BLYS266
BASP268
BVAL269
BCYS321
BALA322
BTHR323
BMG352
BHOH372
BHOH373
BHOH379
BHOH405
BHOH474

site_idBC3
Number of Residues29
DetailsBINDING SITE FOR RESIDUE GSP C 351
ChainResidue
CASP268
CVAL269
CCYS321
CALA322
CTHR323
CMG352
CHOH383
CHOH384
CHOH431
CHOH432
CHOH447
CGLY38
CGLU39
CSER40
CGLY41
CLYS42
CSER43
CTHR44
CASP146
CSER147
CLEU171
CARG172
CSER173
CARG174
CTHR177
CGLY198
CGLY199
CASN265
CLYS266

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues9
DetailsBINDING: BINDING => ECO:0000269|PubMed:7969474, ECO:0000269|PubMed:8208289, ECO:0000269|PubMed:8259210, ECO:0007744|PDB:1FQJ, ECO:0007744|PDB:1FQK, ECO:0007744|PDB:1GOT, ECO:0007744|PDB:1TAD, ECO:0007744|PDB:1TAG, ECO:0007744|PDB:1TND, ECO:0007744|PDB:3V00
ChainResidueDetails
AALA37
ASER147
AARG172
BALA37
BSER147
BARG172
CALA37
CSER147
CARG172

site_idSWS_FT_FI2
Number of Residues6
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01230
ChainResidueDetails
ATHR44
ATHR178
BTHR44
BTHR178
CTHR44
CTHR178

site_idSWS_FT_FI3
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:8259210, ECO:0007744|PDB:1TND
ChainResidueDetails
AGLN200
ATHR323
BGLN200
BTHR323
CGLN200
CTHR323

site_idSWS_FT_FI4
Number of Residues3
DetailsBINDING: BINDING => ECO:0000269|PubMed:7969474, ECO:0000269|PubMed:8208289, ECO:0000269|PubMed:8259210, ECO:0007744|PDB:1GOT, ECO:0007744|PDB:1TAD, ECO:0007744|PDB:1TAG, ECO:0007744|PDB:1TND
ChainResidueDetails
ALYS266
BLYS266
CLYS266

site_idSWS_FT_FI5
Number of Residues3
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P11488
ChainResidueDetails
AGLN143
BGLN143
CGLN143

220113

PDB entries from 2024-05-22

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