1KZI
Crystal Structure of EcTS/dUMP/THF Complex
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0003723 | molecular_function | RNA binding |
A | 0004799 | molecular_function | thymidylate synthase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006231 | biological_process | dTMP biosynthetic process |
A | 0006235 | biological_process | dTTP biosynthetic process |
A | 0006417 | biological_process | regulation of translation |
A | 0008168 | molecular_function | methyltransferase activity |
A | 0009165 | biological_process | nucleotide biosynthetic process |
A | 0009314 | biological_process | response to radiation |
A | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
A | 0032259 | biological_process | methylation |
A | 0042803 | molecular_function | protein homodimerization activity |
B | 0000287 | molecular_function | magnesium ion binding |
B | 0003723 | molecular_function | RNA binding |
B | 0004799 | molecular_function | thymidylate synthase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0006231 | biological_process | dTMP biosynthetic process |
B | 0006235 | biological_process | dTTP biosynthetic process |
B | 0006417 | biological_process | regulation of translation |
B | 0008168 | molecular_function | methyltransferase activity |
B | 0009165 | biological_process | nucleotide biosynthetic process |
B | 0009314 | biological_process | response to radiation |
B | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
B | 0032259 | biological_process | methylation |
B | 0042803 | molecular_function | protein homodimerization activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CO3 A 803 |
Chain | Residue |
A | ARG99 |
A | HOH558 |
A | HOH738 |
site_id | AC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CO3 A 804 |
Chain | Residue |
A | ARG49 |
A | GLY257 |
A | HOH493 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CO3 A 805 |
Chain | Residue |
A | HOH744 |
A | GLU223 |
A | ARG225 |
A | HIS255 |
site_id | AC4 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE UMP A 302 |
Chain | Residue |
A | ARG21 |
A | TYR94 |
A | CYS146 |
A | HIS147 |
A | GLN165 |
A | ARG166 |
A | SER167 |
A | CYS168 |
A | ASP169 |
A | ASN177 |
A | HIS207 |
A | TYR209 |
A | THG303 |
A | HOH412 |
A | HOH432 |
A | HOH658 |
B | ARG126 |
B | ARG127 |
site_id | AC5 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE THG A 303 |
Chain | Residue |
A | HIS51 |
A | ILE79 |
A | TRP80 |
A | TRP83 |
A | LEU143 |
A | ASP169 |
A | GLY173 |
A | PHE176 |
A | VAL262 |
A | ALA263 |
A | UMP302 |
A | HOH419 |
A | HOH442 |
A | HOH448 |
A | HOH467 |
A | HOH551 |
A | HOH575 |
A | HOH597 |
A | HOH615 |
A | HOH625 |
A | HOH646 |
site_id | AC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DTU A 800 |
Chain | Residue |
A | LEU116 |
A | LYS120 |
A | GLN191 |
A | CYS192 |
site_id | AC7 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE UMP B 304 |
Chain | Residue |
A | ARG126 |
A | ARG127 |
B | ARG21 |
B | CYS146 |
B | HIS147 |
B | GLN165 |
B | ARG166 |
B | SER167 |
B | CYS168 |
B | ASP169 |
B | ASN177 |
B | HIS207 |
B | TYR209 |
B | THG305 |
B | HOH439 |
B | HOH509 |
site_id | AC8 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE THG B 305 |
Chain | Residue |
B | ILE79 |
B | TRP83 |
B | LEU143 |
B | ASP169 |
B | GLY173 |
B | VAL262 |
B | ALA263 |
B | UMP304 |
B | HOH461 |
B | HOH480 |
B | HOH569 |
B | HOH737 |
B | HOH749 |
site_id | AC9 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE DTT B 802 |
Chain | Residue |
B | PRO224 |
B | ARG225 |
B | PRO226 |
B | ARG234 |
B | ARG243 |
B | GLU245 |
B | ASP246 |
B | HOH735 |
site_id | BC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL A 801 |
Chain | Residue |
A | GLN9 |
A | GLN64 |
A | ARG99 |
A | HOH599 |
Functional Information from PROSITE/UniProt
site_id | PS00091 |
Number of Residues | 29 |
Details | THYMIDYLATE_SYNTHASE Thymidylate synthase active site. RriIvsaWNvgeldkma.....LaPCHaffQFyV |
Chain | Residue | Details |
A | ARG126-VAL154 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Nucleophile => ECO:0000255|HAMAP-Rule:MF_00008, ECO:0000269|PubMed:2223754, ECO:0000269|PubMed:8973201, ECO:0000269|PubMed:9416600 |
Chain | Residue | Details |
A | CYS146 | |
B | CYS146 |
site_id | SWS_FT_FI2 |
Number of Residues | 8 |
Details | BINDING: in other chain => ECO:0000269|PubMed:2223754, ECO:0000269|PubMed:8973201, ECO:0007744|PDB:1KCE, ECO:0007744|PDB:2TSC |
Chain | Residue | Details |
B | ARG21 | |
B | ARG166 | |
B | ASN177 | |
B | HIS207 | |
A | ARG21 | |
A | ARG166 | |
A | ASN177 | |
A | HIS207 |
site_id | SWS_FT_FI3 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000305|PubMed:8312270, ECO:0007744|PDB:1TYS |
Chain | Residue | Details |
A | ALA263 | |
B | HIS51 | |
B | ASP169 | |
B | ALA263 | |
A | HIS51 | |
A | ASP169 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:2223754, ECO:0000269|PubMed:8973201, ECO:0007744|PDB:1KCE, ECO:0007744|PDB:2TSC |
Chain | Residue | Details |
A | ARG126 | |
B | ARG126 |