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4HYT
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BU of 4hyt by Molmil
Na,K-ATPase in the E2P state with bound ouabain and Mg2+ in the cation-binding site
Descriptor: 1-O-decanoyl-beta-D-tagatofuranosyl beta-D-allopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Laursen, M, Yatime, L, Nissen, P, Fedosova, N.U.
Deposit date:2012-11-14
Release date:2013-06-26
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.404 Å)
Cite:Crystal structure of the high-affinity Na+,K+-ATPase-ouabain complex with Mg2+ bound in the cation binding site.
Proc.Natl.Acad.Sci.USA, 110, 2013
4RES
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BU of 4res by Molmil
Crystal structure of the Na,K-ATPase E2P-bufalin complex with bound potassium
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ...
Authors:Laursen, M, Yatime, L, Gregersen, J.L, Nissen, P, Fedosova, N.U.
Deposit date:2014-09-23
Release date:2015-01-28
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.408 Å)
Cite:Structures and characterization of digoxin- and bufalin-bound Na+,K+-ATPase compared with the ouabain-bound complex.
Proc.Natl.Acad.Sci.USA, 112, 2015
3FGO
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BU of 3fgo by Molmil
Crystal Structure of the E2 magnesium fluoride complex of the (SR) Ca2+-ATPase with bound CPA and AMPPCP
Descriptor: (6AR,11AS,11BR)-10-ACETYL-9-HYDROXY-7,7-DIMETHYL-2,6,6A,7,11A,11B-HEXAHYDRO-11H-PYRROLO[1',2':2,3]ISOINDOLO[4,5,6-CD]INDOL-11-ONE, ACETATE ION, MAGNESIUM ION, ...
Authors:Laursen, M, Bublitz, M, Moncoq, K, Olesen, C, Moller, J.V, Young, H.S, Nissen, P, Morth, J.P.
Deposit date:2008-12-08
Release date:2009-04-07
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Cyclopiazonic acid is complexed to a divalent metal ion when bound to the sarcoplasmic reticulum Ca2+-ATPase.
J.Biol.Chem., 2009
8P4Z
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BU of 8p4z by Molmil
Crystal structure of the human CDK7 kinase domain in complex with LDC4297
Descriptor: 2-[(3R)-piperidin-3-yl]oxy-8-propan-2-yl-N-[(2-pyrazol-1-ylphenyl)methyl]pyrazolo[1,5-a][1,3,5]triazin-4-amine, Cyclin-dependent kinase 7, GLYCEROL, ...
Authors:Laursen, M, Caing-Carlsson, R, Houssari, R, Javadi, A, Kimbung, Y.R, Murina, V, Orozco-Rodriguez, J.M, Svensson, A, Welin, M, Logan, D, Svensson, B, Walse, B.
Deposit date:2023-05-23
Release date:2023-06-14
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Crystal structure of the human CDK7 kinase domain in complex with LDC4297
To Be Published
7BAX
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BU of 7bax by Molmil
Crystal structure of LYS11 ectodomain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, LysM type receptor kinase
Authors:Laursen, M, Cheng, J, Gysel, K, Blaise, M, Andersen, K.R.
Deposit date:2020-12-16
Release date:2021-11-10
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Kinetic proofreading of lipochitooligosaccharides determines signal activation of symbiotic plant receptors.
Proc.Natl.Acad.Sci.USA, 118, 2021
4RET
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BU of 4ret by Molmil
Crystal structure of the Na,K-ATPase E2P-digoxin complex with bound magnesium
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ...
Authors:Gregersen, J.L, Laursen, M, Yatime, L, Nissen, P, Fedosova, N.U.
Deposit date:2014-09-23
Release date:2015-01-28
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structures and characterization of digoxin- and bufalin-bound Na+,K+-ATPase compared with the ouabain-bound complex.
Proc.Natl.Acad.Sci.USA, 112, 2015
8RP8
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BU of 8rp8 by Molmil
Structure of K2 Fab in complex with human CD47 ECD
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Laursen, M, Kelpsas, V, Rose, N.
Deposit date:2024-01-12
Release date:2024-06-19
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural analysis of light chain-driven bispecific antibodies targeting CD47 and PD-L1.
Mabs, 16, 2024
3FPS
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BU of 3fps by Molmil
The Structure of Sarcoplasmic Reticulum Ca2+-ATPase Bound To Cyclopiazonic and ADP
Descriptor: (6AR,11AS,11BR)-10-ACETYL-9-HYDROXY-7,7-DIMETHYL-2,6,6A,7,11A,11B-HEXAHYDRO-11H-PYRROLO[1',2':2,3]ISOINDOLO[4,5,6-CD]INDOL-11-ONE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Moncoq, K, Morth, J.P, Bublitz, M, Laursen, M, Nissen, P, Young, H.S.
Deposit date:2009-01-06
Release date:2009-04-07
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Cyclopiazonic acid is complexed to a divalent metal ion when bound to the sarcoplasmic reticulum Ca2+-ATPase.
J.Biol.Chem., 284, 2009
3FPB
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BU of 3fpb by Molmil
The Structure of Sarcoplasmic Reticulum Ca2+-ATPase Bound To Cyclopiazonic acid with ATP
Descriptor: (6AR,11AS,11BR)-10-ACETYL-9-HYDROXY-7,7-DIMETHYL-2,6,6A,7,11A,11B-HEXAHYDRO-11H-PYRROLO[1',2':2,3]ISOINDOLO[4,5,6-CD]INDOL-11-ONE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Moncoq, K, Morth, J.P, Bublitz, M, Laursen, M, Nissen, P, Young, H.S.
Deposit date:2009-01-05
Release date:2009-04-07
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Cyclopiazonic acid is complexed to a divalent metal ion when bound to the sarcoplasmic reticulum Ca2+-ATPase.
J.Biol.Chem., 284, 2009
6LN2
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BU of 6ln2 by Molmil
Crystal structure of full length human GLP1 receptor in complex with Fab fragment (Fab7F38)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab7F38_heavy chain, Fab7F38_light chain, ...
Authors:Wu, F, Yang, L, Hang, K, Laursen, M, Wu, L, Han, G.W, Ren, Q, Roed, N.K, Lin, G, Hanson, M, Jiang, H, Wang, M, Reedtz-Runge, S, Song, G, Stevens, R.C.
Deposit date:2019-12-28
Release date:2020-03-18
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Full-length human GLP-1 receptor structure without orthosteric ligands.
Nat Commun, 11, 2020
8RPB
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BU of 8rpb by Molmil
Structure of S79 Fab in complex with IgV domain of human PD-L1
Descriptor: CHLORIDE ION, GLYCEROL, Programmed cell death 1 ligand 1, ...
Authors:Svensson, A, Kelpsas, V, Laursen, M, Rose, N.
Deposit date:2024-01-15
Release date:2024-06-19
Method:X-RAY DIFFRACTION (2.794 Å)
Cite:Structural analysis of light chain-driven bispecific antibodies targeting CD47 and PD-L1.
Mabs, 16, 2024
3N23
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BU of 3n23 by Molmil
Crystal structure of the high affinity complex between ouabain and the E2P form of the sodium-potassium pump
Descriptor: MAGNESIUM ION, Na+/K+ ATPase gamma subunit transcript variant a, OUABAIN, ...
Authors:Yatime, L, Laursen, M, Morth, J.P, Esmann, M, Nissen, P, Fedosova, N.U.
Deposit date:2010-05-17
Release date:2011-01-19
Last modified:2014-09-17
Method:X-RAY DIFFRACTION (4.6 Å)
Cite:Structural insights into the high affinity binding of cardiotonic steroids to the Na+,K+-ATPase.
J.Struct.Biol., 174, 2011
7PY4
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BU of 7py4 by Molmil
Cryo-EM structure of ATP8B1-CDC50A in E2P autoinhibited state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, BERYLLIUM TRIFLUORIDE ION, CHOLESTEROL HEMISUCCINATE, ...
Authors:Dieudonne, T, Abad-Herrera, S, Juknaviciute Laursen, M, Lejeune, M, Stock, C, Slimani, K, Jaxel, C, Lyons, J.A, Montigny, C, Gunther Pomorski, T, Nissen, P, Lenoir, G.
Deposit date:2021-10-08
Release date:2022-04-27
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Autoinhibition and regulation by phosphoinositides of ATP8B1, a human lipid flippase associated with intrahepatic cholestatic disorders.
Elife, 11, 2022
7AU7
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BU of 7au7 by Molmil
Crystal structure of Nod Factor Perception ectodomain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Serine/threonine receptor-like kinase NFP, ...
Authors:Gysel, K, Blaise, M, Andersen, K.R.
Deposit date:2020-11-02
Release date:2021-11-10
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.547 Å)
Cite:Kinetic proofreading of lipochitooligosaccharides determines signal activation of symbiotic plant receptors.
Proc.Natl.Acad.Sci.USA, 118, 2021
8OXA
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BU of 8oxa by Molmil
Cryo-EM structure of ATP8B1-CDC50A in E2-Pi conformation with occluded PS
Descriptor: (2~{S})-2-azanyl-3-[[(2~{R})-3-hexadecanoyloxy-2-[(~{Z})-octadec-9-enoyl]oxy-propoxy]-oxidanyl-phosphoryl]oxy-propanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, Cell cycle control protein 50A, ...
Authors:Dieudonne, T, Kummerer, F, Juknaviciute Laursen, M, Stock, C, Kock Flygaard, R, Khalid, S, Lenoir, G, Lyons, J.A, Lindorff-Larsen, K, Nissen, P.
Deposit date:2023-05-01
Release date:2023-11-29
Method:ELECTRON MICROSCOPY (2.76 Å)
Cite:Activation and substrate specificity of the human P4-ATPase ATP8B1.
Nat Commun, 14, 2023
8OX7
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BU of 8ox7 by Molmil
Cryo-EM structure of ATP8B1-CDC50A in E2P autoinhibited "closed" conformation
Descriptor: (2R)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy)phosphoryl]oxy}propane -1,2-diyl dioctanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Cell cycle control protein 50A, ...
Authors:Dieudonne, T, Kummerer, F, Juknaviciute Laursen, M, Stock, C, Kock Flygaard, R, Khalid, S, Lenoir, G, Lyons, J.A, Lindorff-Larsen, K, Nissen, P.
Deposit date:2023-05-01
Release date:2023-11-29
Method:ELECTRON MICROSCOPY (2.56 Å)
Cite:Activation and substrate specificity of the human P4-ATPase ATP8B1.
Nat Commun, 14, 2023
8OX6
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BU of 8ox6 by Molmil
Cryo-EM structure of ATP8B1-CDC50A in E1P conformation
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Cell cycle control protein 50A, MAGNESIUM ION, ...
Authors:Dieudonne, T, Kummerer, F, Juknaviciute Laursen, M, Stock, C, Kock Flygaard, R, Khalid, S, Lenoir, G, Lyons, J.A, Lindorff-Larsen, K, Nissen, P.
Deposit date:2023-05-01
Release date:2023-11-29
Method:ELECTRON MICROSCOPY (2.39 Å)
Cite:Activation and substrate specificity of the human P4-ATPase ATP8B1.
Nat Commun, 14, 2023
8OXB
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BU of 8oxb by Molmil
Cryo-EM structure of ATP8B1-CDC50A in E2-Pi conformation with occluded PC
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Cell cycle control protein 50A, ...
Authors:Dieudonne, T, Kummerer, F, Juknaviciute Laursen, M, Stock, C, Kock Flygaard, R, Khalid, S, Lenoir, G, Lyons, J.A, Lindorff-Larsen, K, Nissen, P.
Deposit date:2023-05-01
Release date:2023-11-29
Method:ELECTRON MICROSCOPY (2.99 Å)
Cite:Activation and substrate specificity of the human P4-ATPase ATP8B1.
Nat Commun, 14, 2023
8OX8
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BU of 8ox8 by Molmil
Cryo-EM structure of ATP8B1-CDC50A in E2P autoinhibited "open" conformation
Descriptor: (2R)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy)phosphoryl]oxy}propane -1,2-diyl dioctanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Cell cycle control protein 50A, ...
Authors:Dieudonne, T, Kummerer, F, Juknaviciute Laursen, M, Stock, C, Kock Flygaard, R, Khalid, S, Lenoir, G, Lyons, J.A, Lindorff-Larsen, K, Nissen, P.
Deposit date:2023-05-01
Release date:2023-11-29
Method:ELECTRON MICROSCOPY (2.98 Å)
Cite:Activation and substrate specificity of the human P4-ATPase ATP8B1.
Nat Commun, 14, 2023
8OX5
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BU of 8ox5 by Molmil
Cryo-EM structure of ATP8B1-CDC50A in E1P-ADP conformation
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-DIPHOSPHATE, Cell cycle control protein 50A, ...
Authors:Dieudonne, T, Kummerer, F, Juknaviciute Laursen, M, Stock, C, Kock Flygaard, R, Khalid, S, Lenoir, G, Lyons, J.A, Lindorff-Larsen, K, Nissen, P.
Deposit date:2023-05-01
Release date:2023-11-29
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Activation and substrate specificity of the human P4-ATPase ATP8B1.
Nat Commun, 14, 2023
8OXC
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BU of 8oxc by Molmil
Cryo-EM structure of ATP8B1-CDC50A in E2-Pi conformation with occluded PI
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOINOSITOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Cell cycle control protein 50A, ...
Authors:Dieudonne, T, Kummerer, F, Juknaviciute Laursen, M, Stock, C, Kock Flygaard, R, Khalid, S, Lenoir, G, Lyons, J.A, Lindorff-Larsen, K, Nissen, P.
Deposit date:2023-05-01
Release date:2023-11-29
Method:ELECTRON MICROSCOPY (2.58 Å)
Cite:Activation and substrate specificity of the human P4-ATPase ATP8B1.
Nat Commun, 14, 2023
8OX4
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BU of 8ox4 by Molmil
Cryo-EM structure of ATP8B1-CDC50A in E1-ATP conformation
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Cell cycle control protein 50A, MAGNESIUM ION, ...
Authors:Dieudonne, T, Kummerer, F, Juknaviciute Laursen, M, Stock, C, Kock Flygaard, R, Khalid, S, Lenoir, G, Lyons, J.A, Lindorff-Larsen, K, Nissen, P.
Deposit date:2023-05-01
Release date:2023-11-29
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Activation and substrate specificity of the human P4-ATPase ATP8B1.
Nat Commun, 14, 2023
8OX9
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BU of 8ox9 by Molmil
Cryo-EM structure of ATP8B1-CDC50A in E2P active conformation with bound PC
Descriptor: (2R)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy)phosphoryl]oxy}propane -1,2-diyl dioctanoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Dieudonne, T, Kummerer, F, Juknaviciute Laursen, M, Stock, C, Kock Flygaard, R, Khalid, S, Lenoir, G, Lyons, J.A, Lindorff-Larsen, K, Nissen, P.
Deposit date:2023-05-01
Release date:2023-11-29
Method:ELECTRON MICROSCOPY (2.72 Å)
Cite:Activation and substrate specificity of the human P4-ATPase ATP8B1.
Nat Commun, 14, 2023
4BEW
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BU of 4bew by Molmil
SERCA bound to phosphate analogue
Descriptor: (6AR,11AS,11BR)-10-ACETYL-9-HYDROXY-7,7-DIMETHYL-2,6,6A,7,11A,11B-HEXAHYDRO-11H-PYRROLO[1',2':2,3]ISOINDOLO[4,5,6-CD]INDOL-11-ONE, ACETATE ION, MAGNESIUM ION, ...
Authors:Drachmann, N.D, Mattle, D, Laursen, M, Bublitz, M, Olesen, C, Moeller, J.V, Nissen, P, Morth, J.P.
Deposit date:2013-03-12
Release date:2014-02-19
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Serca Bound to Phosphate Analogue
To be Published

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