4RES

Crystal structure of the Na,K-ATPase E2P-bufalin complex with bound potassium

Replaces:  3N2F

Summary for 4RES

• Entry DOI: 10.2210/pdb4res/pdb
• Related: 3N23 4HYT 4RET
• Related PRD ID: PRD_900003
• Descriptor: Sodium/potassium-transporting ATPase subunit alpha-1, 2-acetamido-2-deoxy-beta-D-glucopyranose, O-[(S)-({(2R)-2,3-bis[(9Z)-octadec-9-enoyloxy]propyl}oxy)(hydroxy)phosphoryl]-L-serine, ... (11 entities in total)
• Functional Keywords: alpha-helical transmembrane protein, atpase, sodium ion transport, potassium ion transport, atp binding, sodium binding, potassium binding, receptor for cardiotonic steroids, phosphorylation, glycosylation, plasma membrane, multisubunit complex, trimeric complex, membrane protein, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Sus scrofa (pig); More
• Total number of polymer chains: 6
• Total formula weight: 314299.96

Authors

Laursen, M.,Yatime, L.,Gregersen, J.L.,Nissen, P.,Fedosova, N.U. (deposition date: 2014-09-23, release date: 2015-01-28, Last modification date: 2023-09-20)

• Primary citation: Laursen, M.,Gregersen, J.L.,Yatime, L.,Nissen, P.,Fedosova, N.U.; Structures and characterization of digoxin- and bufalin-bound Na+,K+-ATPase compared with the ouabain-bound complex.; Proc.Natl.Acad.Sci.USA, 112:1755-1760, 2015; PubMed: 25624492; DOI: 10.1073/pnas.1422997112

Experimental method

X-RAY DIFFRACTION (3.408 Å)