4RET

Crystal structure of the Na,K-ATPase E2P-digoxin complex with bound magnesium

Summary for 4RET

Entry DOI	10.2210/pdb4ret/pdb
Related	3N23 4HYT 4RES
Related PRD ID	PRD_900003
Descriptor	Sodium/potassium-transporting ATPase subunit alpha-1, 2-acetamido-2-deoxy-beta-D-glucopyranose, Sodium/potassium-transporting ATPase subunit beta-1, ... (11 entities in total)
Functional Keywords	alpha-helical transmembrane protein, atpase, sodium ion transport, potassium ion transport, atp binding, sodium binding, potassium binding, receptor for cardiotonic steroids, phosphorylation, glycosylation, plasma membrane, multisubunit complex, trimeric complex, membrane protein, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Sus scrofa (pig) More
Total number of polymer chains	6
Total formula weight	317964.44
Authors	Gregersen, J.L.,Laursen, M.,Yatime, L.,Nissen, P.,Fedosova, N.U. (deposition date: 2014-09-23, release date: 2015-01-28, Last modification date: 2023-09-20)
Primary citation	Laursen, M.,Gregersen, J.L.,Yatime, L.,Nissen, P.,Fedosova, N.U. Structures and characterization of digoxin- and bufalin-bound Na+,K+-ATPase compared with the ouabain-bound complex. Proc.Natl.Acad.Sci.USA, 112:1755-1760, 2015 Cited by PubMed: 25624492 DOI: 10.1073/pnas.1422997112 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (4 Å)

Structure validation