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1EVJ
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BU of 1evj by Molmil
CRYSTAL STRUCTURE OF GLUCOSE-FRUCTOSE OXIDOREDUCTASE (GFOR) DELTA1-22 S64D
Descriptor: GLUCOSE-FRUCTOSE OXIDOREDUCTASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Lott, J.S, Halbig, D, Baker, H.M, Hardman, M.J, Sprenger, G.A, Baker, E.N.
Deposit date:2000-04-20
Release date:2000-12-04
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of a truncated mutant of glucose-fructose oxidoreductase shows that an N-terminal arm controls tetramer formation.
J.Mol.Biol., 304, 2000
2GL0
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BU of 2gl0 by Molmil
Structure of PAE2307 in complex with adenosine
Descriptor: ADENOSINE, PHOSPHATE ION, conserved hypothetical protein
Authors:Lott, J.S, Paget, B, Johnston, J.M, Baker, E.N.
Deposit date:2006-04-04
Release date:2006-06-06
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:The Structure of an Ancient Conserved Domain Establishes a Structural Basis for Stable Histidine Phosphorylation and Identifies a New Family of Adenosine-specific Kinases.
J.Biol.Chem., 281, 2006
1WVQ
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BU of 1wvq by Molmil
Structure of conserved hypothetical protein PAE2307 from Pyrobaculum aerophilum
Descriptor: PHOSPHATE ION, hypothetical protein PAE2307
Authors:Lott, J.S, Delbaere, L.T, Banfield, M.J, Sigrell-Simon, J.A, Baker, E.N.
Deposit date:2004-12-24
Release date:2006-01-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:The structure of an ancient conserved domain establishes a structural basis for stable histidine phosphorylation and identifies a new family of adenosine-specific kinases.
J.Biol.Chem., 281, 2006
4NF7
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BU of 4nf7 by Molmil
Crystal structure of the GH5 family catalytic domain of Endo-1,4-beta-glucanase Cel5C from Butyrivibrio proteoclasticus.
Descriptor: Endo-1,4-beta-glucanase Cel5C
Authors:Lott, J.S, Colbert, D.A.
Deposit date:2013-10-30
Release date:2014-11-05
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.111 Å)
Cite:Structural and functional characterisation of endo-1,4-beta-glucanase Cel5C from bovine rumen microbe Butyrivibrio proteoclasticus
To be Published
4M0R
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BU of 4m0r by Molmil
Trianthranilate-like analogue bound to anthranilate phosphoribosyltransferase (AnPRT; TrpD).
Descriptor: 2,6-bis[(2-carboxyphenyl)amino]benzoic acid, Anthranilate phosphoribosyltransferase, DIMETHYL SULFOXIDE, ...
Authors:Evans, G.L, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
Deposit date:2013-08-02
Release date:2014-05-21
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Repurposing the Chemical Scaffold of the Anti-Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis in Mycobacterium tuberculosis.
Chembiochem, 15, 2014
1H5Y
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BU of 1h5y by Molmil
HisF protein from Pyrobaculum aerophilum
Descriptor: GLYCEROL, HISF, PHOSPHATE ION
Authors:Banfield, M.J, Lott, J.S, McCarthy, A.A, Baker, E.N.
Deposit date:2001-05-31
Release date:2001-06-01
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of Hisf, a Histidine Biosynthetic Protein from Pyrobaculum Aerophilum
Acta Crystallogr.,Sect.D, 57, 2001
4XVX
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BU of 4xvx by Molmil
Crystal structure of an acyl-ACP dehydrogenase
Descriptor: 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, Acyl-[acyl-carrier-protein] dehydrogenase MbtN, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, ...
Authors:Chai, A, Johnston, J.M, Bunker, R.D, Lott, J.S, Baker, E.N, TB Structural Genomics Consortium (TBSGC)
Deposit date:2015-01-28
Release date:2015-02-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A covalent adduct of MbtN, an acyl-ACP dehydrogenase from Mycobacterium tuberculosis, reveals an unusual acyl-binding pocket.
Acta Crystallogr.,Sect.D, 71, 2015
4A5Q
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BU of 4a5q by Molmil
Crystal structure of the chitinase Chi1 fitted into the 3D structure of the Yersinia entomophaga toxin complex
Descriptor: CHI1
Authors:Busby, J.N, Landsberg, M.J, Simpson, R.M, Jones, S.A, Hankamer, B, Hurst, M.R.H, Lott, J.S.
Deposit date:2011-10-27
Release date:2011-11-16
Last modified:2024-01-31
Method:ELECTRON MICROSCOPY (17 Å)
Cite:Structural Analysis of Chi1 Chitinase from Yen-Tc: The Multisubunit Insecticidal Abc Toxin Complex of Yersinia Entomophaga.
J.Mol.Biol., 415, 2012
3R6C
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BU of 3r6c by Molmil
Anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis (complex with inhibitor ACS179)
Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 8-methoxyphenanthro[3,4-d][1,3]dioxole-5,6-dicarboxylic acid, Anthranilate phosphoribosyltransferase, ...
Authors:Castell, A, Short, F.L, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
Deposit date:2011-03-21
Release date:2012-09-26
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition.
Biochemistry, 52, 2013
3RV9
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BU of 3rv9 by Molmil
Structure of a M. tuberculosis Salicylate Synthase, MbtI, in Complex with an Inhibitor with Ethyl R-Group
Descriptor: 3-{[(1Z)-1-carboxybut-1-en-1-yl]oxy}-2-hydroxybenzoic acid, Isochorismate synthase/isochorismate-pyruvate lyase mbtI
Authors:Chi, G, Bulloch, E.M.M, Manos-Turvey, A, Payne, R.J, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
Deposit date:2011-05-06
Release date:2012-05-09
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis
Biochemistry, 51, 2012
3RV8
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BU of 3rv8 by Molmil
Structure of a M. tuberculosis Salicylate Synthase, MbtI, in Complex with an Inhibitor with Cyclopropyl R-Group
Descriptor: 3-{[(E)-1-carboxy-2-cyclopropylethenyl]oxy}-2-hydroxybenzoic acid, 3-{[(Z)-1-carboxy-2-cyclopropylethenyl]oxy}-2-hydroxybenzoic acid, Isochorismate synthase/isochorismate-pyruvate lyase mbtI
Authors:Chi, G, Bulloch, E.M.M, Manos-Turvey, A, Payne, R.J, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
Deposit date:2011-05-06
Release date:2012-05-09
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis
Biochemistry, 51, 2012
3RV6
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BU of 3rv6 by Molmil
Structure of a M. tuberculosis Salicylate Synthase, MbtI, in Complex with an Inhibitor with Phenyl R-Group
Descriptor: 3-{[(E)-1-carboxy-2-phenylethenyl]oxy}-2-hydroxybenzoic acid, 3-{[(Z)-1-carboxy-2-phenylethenyl]oxy}-2-hydroxybenzoic acid, Isochorismate synthase/isochorismate-pyruvate lyase mbtI, ...
Authors:Chi, G, Bulloch, E.M.M, Manos-Turvey, A, Payne, R.J, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
Deposit date:2011-05-06
Release date:2012-05-09
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis
Biochemistry, 51, 2012
3RV7
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BU of 3rv7 by Molmil
Structure of a M. tuberculosis Salicylate Synthase, MbtI, in Complex with an Inhibitor with Isopropyl R-Group
Descriptor: 3-{[(1Z)-1-carboxy-3-methylbut-1-en-1-yl]oxy}-2-hydroxybenzoic acid, Isochorismate synthase/isochorismate-pyruvate lyase mbtI
Authors:Chi, G, Bulloch, E.M.M, Manos-Turvey, A, Payne, R.J, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
Deposit date:2011-05-06
Release date:2012-05-09
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis
Biochemistry, 51, 2012
3ITE
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BU of 3ite by Molmil
The third adenylation domain of the fungal SidN non-ribosomal peptide synthetase
Descriptor: CHLORIDE ION, SULFATE ION, SidN siderophore synthetase
Authors:Lee, T.V, Lott, J.S, Johnson, R.D, Johnson, L.J, Arcus, V.L.
Deposit date:2009-08-28
Release date:2009-11-17
Last modified:2014-02-05
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of a eukaryotic nonribosomal peptide synthetase adenylation domain that activates a large hydroxamate amino acid in siderophore biosynthesis
J.Biol.Chem., 285, 2010
3LOG
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BU of 3log by Molmil
Crystal structure of MbtI from Mycobacterium tuberculosis
Descriptor: CARBONATE ION, GLYCEROL, Isochorismate synthase/isochorismate-pyruvate lyase mbtI, ...
Authors:Bulloch, E.M.M, Lott, J.S, Baker, E.N, Johnston, J.M.
Deposit date:2010-02-03
Release date:2011-02-09
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Inhibition studies of Mycobacterium tuberculosis salicylate synthase (MbtI).
Chemmedchem, 5, 2010
3MNL
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BU of 3mnl by Molmil
The crystal structure of KstR (Rv3574) from Mycobacterium tuberculosis H37Rv
Descriptor: TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY), TRIETHYLENE GLYCOL
Authors:Gao, C, Bunker, R.D, ten Bokum, A, Kendall, S.L, Stoker, N.G, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
Deposit date:2010-04-21
Release date:2011-04-27
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis.
J. Biol. Chem., 291, 2016
4DWS
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BU of 4dws by Molmil
Crystal Structure of a chitinase from the Yersinia entomophaga toxin complex
Descriptor: Chi2, GLYCEROL
Authors:Busby, J.N, Hurst, M.R.H, Lott, J.S.
Deposit date:2012-02-26
Release date:2013-02-27
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The BC component of ABC toxins is an RHS-repeat-containing protein encapsulation device.
Nature, 501, 2013
4GKM
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BU of 4gkm by Molmil
Bianthranilate-like analogue bound in the outer site of anthranilate phosphoribosyltransferase (AnPRT; trpD)
Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 2-[(2-carboxyphenyl)amino]-5-methylbenzoic acid, Anthranilate phosphoribosyltransferase, ...
Authors:Evans, G.L, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
Deposit date:2012-08-13
Release date:2013-08-14
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.6683 Å)
Cite:Repurposing the Chemical Scaffold of the Anti-Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis in Mycobacterium tuberculosis.
Chembiochem, 15, 2014
4GIU
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BU of 4giu by Molmil
Bianthranilate-like analogue bound in inner site of anthranilate phosphoribosyltransferase (AnPRT; trpD).
Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 2-[(2-carboxy-5-methylphenyl)amino]-3-methylbenzoic acid, Anthranilate phosphoribosyltransferase, ...
Authors:Evans, G.L, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
Deposit date:2012-08-09
Release date:2013-08-14
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.667 Å)
Cite:Repurposing the Chemical Scaffold of the Anti-Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis in Mycobacterium tuberculosis.
Chembiochem, 15, 2014
4W1U
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BU of 4w1u by Molmil
Crystal structure of Rv3557c/KstR2, a transcriptional repressor involved in cholesterol metabolism in Mycobacterium tuberculosis
Descriptor: HTH-type transcriptional repressor KstR2
Authors:Dawes, S.S, Kendall, S.K, Baker, E.N, Lott, J.S.
Deposit date:2014-08-13
Release date:2015-07-29
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.875 Å)
Cite:Crystal structure of Rv3557c/KstR2, a transcriptional repressor involved in cholesterol metabolism in Mycobacterium tuberculosis.
To Be Published
4X58
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BU of 4x58 by Molmil
Anthranilate phosphoribosyl transferase variant N138A from Mycobacterium tuberculosis in complex with PRPP and Mg
Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, Anthranilate phosphoribosyltransferase, D-MALATE, ...
Authors:Cookson, T.V.M, Evans, G.L, Parker, E.J, Lott, J.S.
Deposit date:2014-12-04
Release date:2015-11-25
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site.
Biochemistry, 54, 2015
4X59
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BU of 4x59 by Molmil
Anthranilate phosphoribosyltransferase variant P180A from Mycobacterium tuberculosis in complex with PRPP and Mg
Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, Anthranilate phosphoribosyltransferase, GLYCEROL, ...
Authors:Cookson, T.V.M, Evans, G.L, Parker, E.J, Lott, J.S.
Deposit date:2014-12-04
Release date:2015-11-25
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site.
Biochemistry, 54, 2015
4X5E
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BU of 4x5e by Molmil
Anthranilate phosphoribosyltransferase variant R194A from Mycobacterium tuberculosis with pyrophosphate, Mg2+ and anthranilate bound
Descriptor: 2-AMINOBENZOIC ACID, Anthranilate phosphoribosyltransferase, GLYCEROL, ...
Authors:Cookson, T.V.M, Evans, G.L, Parker, E.J, Lott, J.S.
Deposit date:2014-12-05
Release date:2015-11-25
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site.
Biochemistry, 54, 2015
4X5A
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BU of 4x5a by Molmil
Anthranilate phosphoribosyltransferase variant R193A from Mycobacterium tuberculosis remains ligand-free when co-crystallised with PRPP and Mg
Descriptor: Anthranilate phosphoribosyltransferase, GLYCEROL
Authors:Cookson, T.V.M, Parker, E.J, Lott, J.S.
Deposit date:2014-12-05
Release date:2015-11-25
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site.
Biochemistry, 54, 2015
4X5C
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BU of 4x5c by Molmil
Anthranilate phosphoribosyltransferase variant R193L from Mycobacterium tuberculosis with pyrophosphate/PRPP and Mg2+ bound
Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, Anthranilate phosphoribosyltransferase, MAGNESIUM ION, ...
Authors:Cookson, T.V.M, Parker, E.J, Lott, J.S.
Deposit date:2014-12-05
Release date:2015-11-25
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site.
Biochemistry, 54, 2015

 

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