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5RZW
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BU of 5rzw by Molmil
EPB41L3 PanDDA analysis group deposition -- Crystal Structure of the FERM domain of human EPB41L3 in complex with Z2574937229
Descriptor: (S)-1-(4-methoxyphenyl)-1-phenylmethanamine, 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, ...
Authors:Bradshaw, W.J, Katis, V.L, Newman, J.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Gileadi, O.
Deposit date:2020-10-30
Release date:2020-11-11
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:EPB41L3 PanDDA analysis group deposition
To Be Published
5RZJ
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BU of 5rzj by Molmil
EPB41L3 PanDDA analysis group deposition -- Crystal Structure of the FERM domain of human EPB41L3 in complex with Z2856434938
Descriptor: 1,2-ETHANEDIOL, 1-(5-methoxy-1H-indol-3-yl)-N,N-dimethyl-methanamine, DIMETHYL SULFOXIDE, ...
Authors:Bradshaw, W.J, Katis, V.L, Newman, J.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Gileadi, O.
Deposit date:2020-10-30
Release date:2020-11-11
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:EPB41L3 PanDDA analysis group deposition
To Be Published
5RZZ
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BU of 5rzz by Molmil
EPB41L3 PanDDA analysis group deposition -- Crystal Structure of the FERM domain of human EPB41L3 in complex with Z1551999220
Descriptor: (2R)-3-(4-bromophenyl)-2-methylpropanamide, 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, ...
Authors:Bradshaw, W.J, Katis, V.L, Newman, J.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Gileadi, O.
Deposit date:2020-10-30
Release date:2020-11-11
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:EPB41L3 PanDDA analysis group deposition
To Be Published
5RYP
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BU of 5ryp by Molmil
EPB41L3 PanDDA analysis group deposition -- Crystal Structure of the FERM domain of human EPB41L3 in complex with Z1929757385
Descriptor: (3S)-1-(3-fluoropyridin-2-yl)-4,4-dimethylpyrrolidin-3-ol, 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, ...
Authors:Bradshaw, W.J, Katis, V.L, Newman, J.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Gileadi, O.
Deposit date:2020-10-30
Release date:2020-11-11
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:EPB41L3 PanDDA analysis group deposition
To Be Published
5RZ1
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BU of 5rz1 by Molmil
EPB41L3 PanDDA analysis group deposition -- Crystal Structure of the FERM domain of human EPB41L3 in complex with Z27682767
Descriptor: 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, Isoform 2 of Band 4.1-like protein 3, ...
Authors:Bradshaw, W.J, Katis, V.L, Newman, J.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Gileadi, O.
Deposit date:2020-10-30
Release date:2020-11-11
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:EPB41L3 PanDDA analysis group deposition
To Be Published
5RZ7
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BU of 5rz7 by Molmil
EPB41L3 PanDDA analysis group deposition -- Crystal Structure of the FERM domain of human EPB41L3 in complex with Z57472297
Descriptor: 1,2-ETHANEDIOL, 1-[2-methyl-1,3-bis(oxidanyl)propan-2-yl]-3-phenyl-urea, DIMETHYL SULFOXIDE, ...
Authors:Bradshaw, W.J, Katis, V.L, Newman, J.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Gileadi, O.
Deposit date:2020-10-30
Release date:2020-11-11
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:EPB41L3 PanDDA analysis group deposition
To Be Published
5RZQ
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BU of 5rzq by Molmil
EPB41L3 PanDDA analysis group deposition -- Crystal Structure of the FERM domain of human EPB41L3 in complex with Z100642432
Descriptor: 1,2-ETHANEDIOL, 2-bromo-4-fluoro-N,N-dimethylbenzamide, DIMETHYL SULFOXIDE, ...
Authors:Bradshaw, W.J, Katis, V.L, Newman, J.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Gileadi, O.
Deposit date:2020-10-30
Release date:2020-11-11
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:EPB41L3 PanDDA analysis group deposition
To Be Published
5RZB
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BU of 5rzb by Molmil
EPB41L3 PanDDA analysis group deposition -- Crystal Structure of the FERM domain of human EPB41L3 in complex with Z271004858
Descriptor: 1,2-ETHANEDIOL, 4-amino-N-(pyridin-2-yl)benzenesulfonamide, DIMETHYL SULFOXIDE, ...
Authors:Bradshaw, W.J, Katis, V.L, Newman, J.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Gileadi, O.
Deposit date:2020-10-30
Release date:2020-11-11
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:EPB41L3 PanDDA analysis group deposition
To Be Published
5RZR
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BU of 5rzr by Molmil
EPB41L3 PanDDA analysis group deposition -- Crystal Structure of the FERM domain of human EPB41L3 in complex with Z53825177
Descriptor: 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, Isoform 2 of Band 4.1-like protein 3, ...
Authors:Bradshaw, W.J, Katis, V.L, Newman, J.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Gileadi, O.
Deposit date:2020-10-30
Release date:2020-11-11
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:EPB41L3 PanDDA analysis group deposition
To Be Published
5RYM
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BU of 5rym by Molmil
EPB41L3 PanDDA analysis group deposition -- Crystal Structure of the FERM domain of human EPB41L3 in complex with Z31217395
Descriptor: 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, Isoform 2 of Band 4.1-like protein 3, ...
Authors:Bradshaw, W.J, Katis, V.L, Newman, J.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Gileadi, O.
Deposit date:2020-10-30
Release date:2020-11-11
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:EPB41L3 PanDDA analysis group deposition
To Be Published
5RYY
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BU of 5ryy by Molmil
EPB41L3 PanDDA analysis group deposition -- Crystal Structure of the FERM domain of human EPB41L3 in complex with Z57257264
Descriptor: 1,2-ETHANEDIOL, 1-(3-phenylprop-2-yn-1-yl)piperidine, DIMETHYL SULFOXIDE, ...
Authors:Bradshaw, W.J, Katis, V.L, Newman, J.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Gileadi, O.
Deposit date:2020-10-30
Release date:2020-11-11
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:EPB41L3 PanDDA analysis group deposition
To Be Published
5RZF
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BU of 5rzf by Molmil
EPB41L3 PanDDA analysis group deposition -- Crystal Structure of the FERM domain of human EPB41L3 in complex with Z57040482
Descriptor: 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, Isoform 2 of Band 4.1-like protein 3, ...
Authors:Bradshaw, W.J, Katis, V.L, Newman, J.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Gileadi, O.
Deposit date:2020-10-30
Release date:2020-11-11
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:EPB41L3 PanDDA analysis group deposition
To Be Published
5RZU
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BU of 5rzu by Molmil
EPB41L3 PanDDA analysis group deposition -- Crystal Structure of the FERM domain of human EPB41L3 in complex with Z32400357
Descriptor: 1,2-ETHANEDIOL, 1-(3-methylbenzene-1-carbonyl)piperidine-4-carboxamide, DIMETHYL SULFOXIDE, ...
Authors:Bradshaw, W.J, Katis, V.L, Newman, J.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Gileadi, O.
Deposit date:2020-10-30
Release date:2020-11-11
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:EPB41L3 PanDDA analysis group deposition
To Be Published
5RZ9
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BU of 5rz9 by Molmil
EPB41L3 PanDDA analysis group deposition -- Crystal Structure of the FERM domain of human EPB41L3 in complex with Z943693514
Descriptor: 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, Isoform 2 of Band 4.1-like protein 3, ...
Authors:Bradshaw, W.J, Katis, V.L, Newman, J.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Gileadi, O.
Deposit date:2020-10-30
Release date:2020-11-11
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:EPB41L3 PanDDA analysis group deposition
To Be Published
5RZP
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BU of 5rzp by Molmil
EPB41L3 PanDDA analysis group deposition -- Crystal Structure of the FERM domain of human EPB41L3 in complex with Z33546965
Descriptor: 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, Isoform 2 of Band 4.1-like protein 3, ...
Authors:Bradshaw, W.J, Katis, V.L, Newman, J.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Gileadi, O.
Deposit date:2020-10-30
Release date:2020-11-11
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:EPB41L3 PanDDA analysis group deposition
To Be Published
5RYN
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BU of 5ryn by Molmil
EPB41L3 PanDDA analysis group deposition -- Crystal Structure of the FERM domain of human EPB41L3 in complex with Z1545312521
Descriptor: (2S)-N-(3-chloro-2-methylphenyl)oxolane-2-carboxamide, 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, ...
Authors:Bradshaw, W.J, Katis, V.L, Newman, J.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Gileadi, O.
Deposit date:2020-10-30
Release date:2020-11-11
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:EPB41L3 PanDDA analysis group deposition
To Be Published
5RYW
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BU of 5ryw by Molmil
EPB41L3 PanDDA analysis group deposition -- Crystal Structure of the FERM domain of human EPB41L3 in complex with Z2856434829
Descriptor: 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, Isoform 2 of Band 4.1-like protein 3, ...
Authors:Bradshaw, W.J, Katis, V.L, Newman, J.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Gileadi, O.
Deposit date:2020-10-30
Release date:2020-11-11
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:EPB41L3 PanDDA analysis group deposition
To Be Published
5RZC
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BU of 5rzc by Molmil
EPB41L3 PanDDA analysis group deposition -- Crystal Structure of the FERM domain of human EPB41L3 in complex with Z300245038
Descriptor: 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, Isoform 2 of Band 4.1-like protein 3, ...
Authors:Bradshaw, W.J, Katis, V.L, Newman, J.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Gileadi, O.
Deposit date:2020-10-30
Release date:2020-11-11
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:EPB41L3 PanDDA analysis group deposition
To Be Published
5RZT
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BU of 5rzt by Molmil
EPB41L3 PanDDA analysis group deposition -- Crystal Structure of the FERM domain of human EPB41L3 in complex with Z763030030
Descriptor: 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, Isoform 2 of Band 4.1-like protein 3, ...
Authors:Bradshaw, W.J, Katis, V.L, Newman, J.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Gileadi, O.
Deposit date:2020-10-30
Release date:2020-11-11
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:EPB41L3 PanDDA analysis group deposition
To Be Published
7LWH
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BU of 7lwh by Molmil
Human neurofibromin 2/merlin residues 1-339 in complex with LATS1
Descriptor: GLYCEROL, IMIDAZOLE, Merlin, ...
Authors:Primi, M.C, Rangarajan, E.S, Izard, T.
Deposit date:2021-03-01
Release date:2021-08-11
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.606 Å)
Cite:Conformational flexibility determines the Nf2/merlin tumor suppressor functions.
Matrix Biol Plus, 12, 2021
7EDR
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BU of 7edr by Molmil
The crystal structure of the FERM and C-terminal domain complex of Drosophila Merlin
Descriptor: Moesin/ezrin/radixin homolog 2
Authors:Zhang, F, Long, J, Zhou, H.
Deposit date:2021-03-16
Release date:2021-04-14
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.527 Å)
Cite:The crystal structure of the FERM and C-terminal domain complex of Drosophila Merlin.
Biochem.Biophys.Res.Commun., 553, 2021
8GVL
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BU of 8gvl by Molmil
PTPN21 FERM
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Tyrosine-protein phosphatase non-receptor type 21
Authors:Chen, L, Zheng, Y.Y, Zhou, C.
Deposit date:2022-09-15
Release date:2023-09-20
Last modified:2024-04-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural analysis of PTPN21 reveals a dominant-negative effect of the FERM domain on its phosphatase activity.
Sci Adv, 10, 2024
8GXE
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BU of 8gxe by Molmil
PTPN21 FERM PTP complex
Descriptor: CHLORIDE ION, Tyrosine-protein phosphatase non-receptor type 21
Authors:Chen, L, Zheng, Y.Y, Zhou, C.
Deposit date:2022-09-19
Release date:2023-09-27
Last modified:2024-04-17
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural analysis of PTPN21 reveals a dominant-negative effect of the FERM domain on its phosphatase activity.
Sci Adv, 10, 2024
8CIT
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BU of 8cit by Molmil
The FERM domain of human moesin mutant L281R
Descriptor: Moesin
Authors:Bradshaw, W.J, Katis, V.L, Koekemoer, L, Bountra, C, von Delft, F, Brennan, P.E.
Deposit date:2023-02-10
Release date:2023-03-01
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.536 Å)
Cite:Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease.
J.Biol.Chem., 299, 2023
8CIR
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BU of 8cir by Molmil
The FERM domain of human moesin with a bound peptide identified by phage display
Descriptor: 1,2-ETHANEDIOL, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BROMIDE ION, ...
Authors:Bradshaw, W.J, Katis, V.L, Leisner, T.M, Fairhead, M, Bountra, C, von Delft, F, Pearce, K.H, Brennan, P.E.
Deposit date:2023-02-10
Release date:2023-03-01
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease.
J.Biol.Chem., 299, 2023

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數據於2024-05-22公開中

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