5A6G
 
 | | Cryo-EM structure of the Slo2.2 Na-activated K channel | | Descriptor: | PORE DOMAIN OF POTASSIUM CHANNEL SUBFAMILY T MEMBER 1, S1-S4 DOMAIN OF POTASSIUM CHANNEL SUBFAMILY T MEMBER 1 | | Authors: | Hite, R.K, Yuan, P, Li, Z, Hsuing, Y, Walz, T, MacKinnon, R. | | Deposit date: | 2015-06-25 | | Release date: | 2015-10-14 | | Last modified: | 2019-10-23 | | Method: | ELECTRON MICROSCOPY (4.5 Å) | | Cite: | Cryo-Electron Microscopy Structure of the Slo2.2 Na1-Activated K1 Channel
Nature, 527, 2015
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4I9W
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3HPL
 | | KcsA E71H-F103A mutant in the closed state | | Descriptor: | Antibody Fab heavy chain, Antibody fab light chain, POTASSIUM ION, ... | | Authors: | Cuello, L.G, Jogini, V, Cortes, D.M, Perozo, E. | | Deposit date: | 2009-06-04 | | Release date: | 2010-06-23 | | Last modified: | 2021-10-13 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Structural basis for the coupling between activation and inactivation gates in K(+) channels.
Nature, 466, 2010
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3IGA
 | | Potassium Channel KcsA-Fab complex in Li+ and K+ | | Descriptor: | Antibody Fab Fragment heavy chain, Antibody Fab fragment light chain, DIACYL GLYCEROL, ... | | Authors: | Thompson, A.N, Ilsoo, K, Panosian, T.D, Iverson, T.M, Allen, T.W, Nimigean, C.M. | | Deposit date: | 2009-07-27 | | Release date: | 2009-11-17 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Mechanism of potassium-channel selectivity revealed by Na(+) and Li(+) binding sites within the KcsA pore.
Nat.Struct.Mol.Biol., 16, 2009
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5CBG
 | | Calcium activated non-selective cation channel | | Descriptor: | CALCIUM ION, DECYL-BETA-D-MALTOPYRANOSIDE, Ion transport 2 domain protein | | Authors: | Dhakshnamoorthy, B, Rohaim, A, Rui, H, Blachowicz, L, Roux, B. | | Deposit date: | 2015-06-30 | | Release date: | 2016-07-20 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (3.14 Å) | | Cite: | Structural and functional characterization of a calcium-activated cation channel from Tsukamurella paurometabola.
Nat Commun, 7, 2016
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3K0D
 | | Crystal Structure of CNG mimicking NaK mutant, NaK-ETPP, K+ complex | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, POTASSIUM ION, Potassium channel protein NaK | | Authors: | Jiang, Y, Derebe, M.G. | | Deposit date: | 2009-09-24 | | Release date: | 2011-01-12 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structural studies of ion permeation and Ca2+ blockage of a bacterial channel mimicking the cyclic nucleotide-gated channel pore.
Proc.Natl.Acad.Sci.USA, 108, 2011
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3K08
 | | Crystal Structure of CNG mimicking NaK mutant, NaK-NTPP, Na+ complex | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Potassium channel protein NaK, SODIUM ION | | Authors: | Jiang, Y, Derebe, M.G. | | Deposit date: | 2009-09-24 | | Release date: | 2011-01-12 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.62 Å) | | Cite: | Structural studies of ion permeation and Ca2+ blockage of a bacterial channel mimicking the cyclic nucleotide-gated channel pore.
Proc.Natl.Acad.Sci.USA, 108, 2011
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4H33
 | | Crystal structure of a voltage-gated K+ channel pore module in a closed state in lipid membranes, tetragonal crystal form | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Lmo2059 protein, POTASSIUM ION | | Authors: | Santos, J.S, Asmar-Rovira, G.A, Han, G.W, Liu, W, Syeda, R, Cherezov, V, Baker, K.A, Stevens, R.C, Montal, M. | | Deposit date: | 2012-09-13 | | Release date: | 2012-11-07 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Crystal Structure of a Voltage-gated K+ Channel Pore Module in a Closed State in Lipid Membranes.
J.Biol.Chem., 287, 2012
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3K06
 | | Crystal Structure of CNG mimicking NaK mutant, NaK-NTPP, K+ complex | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, POTASSIUM ION, Potassium channel protein NaK | | Authors: | Jiang, Y, Derebe, M.G. | | Deposit date: | 2009-09-24 | | Release date: | 2011-01-12 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.58 Å) | | Cite: | Structural studies of ion permeation and Ca2+ blockage of a bacterial channel mimicking the cyclic nucleotide-gated channel pore.
Proc.Natl.Acad.Sci.USA, 108, 2011
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3K0G
 | | Crystal Structure of CNG mimicking NaK mutant, NaK-ETPP, Na+ complex | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Potassium channel protein NaK, SODIUM ION | | Authors: | Jiang, Y, Derebe, M.G. | | Deposit date: | 2009-09-24 | | Release date: | 2011-01-12 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structural studies of ion permeation and Ca2+ blockage of a bacterial channel mimicking the cyclic nucleotide-gated channel pore.
Proc.Natl.Acad.Sci.USA, 108, 2011
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4HZ3
 | | MthK pore crystallized in presence of TBSb | | Descriptor: | Calcium-gated potassium channel mthK, HEXANE-1,6-DIOL, POTASSIUM ION | | Authors: | Posson, D.J, McCoy, J.G, Nimigean, C.M. | | Deposit date: | 2012-11-14 | | Release date: | 2012-12-26 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | The voltage-dependent gate in MthK potassium channels is located at the selectivity filter.
Nat.Struct.Mol.Biol., 20, 2013
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4HYO
 | | Crystal Structure of MthK Pore | | Descriptor: | Calcium-gated potassium channel mthK, HEXANE-1,6-DIOL, POTASSIUM ION | | Authors: | Posson, D.J, McCoy, J.G, Nimigean, C.M. | | Deposit date: | 2012-11-13 | | Release date: | 2012-12-26 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | The voltage-dependent gate in MthK potassium channels is located at the selectivity filter.
Nat.Struct.Mol.Biol., 20, 2013
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5CBF
 | | Structural and Functional Characterization of a Calcium-activated Cation channel from Tsukamurella Paurometabola | | Descriptor: | CALCIUM ION, Ion transport 2 domain protein | | Authors: | Dhakshnamoorthy, B, Rohaim, A, Rui, H, Blachowicz, L, Roux, B. | | Deposit date: | 2015-06-30 | | Release date: | 2016-07-20 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (3.61 Å) | | Cite: | Structural and functional characterization of a calcium-activated cation channel from Tsukamurella paurometabola.
Nat Commun, 7, 2016
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2IH3
 | | Ion selectivity in a semi-synthetic K+ channel locked in the conductive conformation | | Descriptor: | (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, FAB Heavy Chain, FAB Light Chain, ... | | Authors: | Valiyaveetil, F.I, Leonetti, M, Muir, T.W, MacKinnon, R. | | Deposit date: | 2006-09-25 | | Release date: | 2006-11-21 | | Last modified: | 2021-10-20 | | Method: | X-RAY DIFFRACTION (1.72 Å) | | Cite: | Ion Selectivity in a Semisynthetic K+ Channel Locked in the Conductive Conformation.
Science, 314, 2006
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2IH1
 | | Ion selectivity in a semi-synthetic K+ channel locked in the conductive conformation | | Descriptor: | (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, FAB Heavy Chain, FAB Light Chain, ... | | Authors: | Valiyaveetil, F.I, Leonetti, M, Muir, T.W, MacKinnon, R. | | Deposit date: | 2006-09-25 | | Release date: | 2006-11-21 | | Last modified: | 2021-10-20 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Ion Selectivity in a Semisynthetic K+ Channel Locked in the Conductive Conformation.
Science, 314, 2006
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2ITD
 | | Potassium Channel KcsA-Fab complex in Barium Chloride | | Descriptor: | BARIUM ION, Voltage-gated potassium channel, antibody Fab fragment heavy chain, ... | | Authors: | Lockless, S.W, Zhou, M, MacKinnon, R. | | Deposit date: | 2006-10-19 | | Release date: | 2007-05-15 | | Last modified: | 2021-10-20 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural and Thermodynamic Properties of Selective Ion Binding in a K(+) Channel.
Plos Biol., 5, 2007
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2HJF
 | | Potassium channel kcsa-fab complex with tetrabutylammonium (TBA) | | Descriptor: | Antibody fragment Heavy chain, Antibody fragment Light chain, POTASSIUM ION, ... | | Authors: | Faraldo-Gomez, J.D, Kutluay, E, Jogini, V, Zhao, Y, Heginbotham, L, Roux, B. | | Deposit date: | 2006-06-30 | | Release date: | 2006-12-05 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Mechanism of Intracellular Block of the KcsA K(+) Channel by Tetrabutylammonium: Insights from X-ray Crystallography, Electrophysiology and Replica-exchange Molecular Dynamics Simulations.
J.Mol.Biol., 365, 2007
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6BY3
 | | Open and conductive conformation of KcsA-T75A mutant | | Descriptor: | Antibody Heavy Chain, Antibody Light Chain, DIACYL GLYCEROL, ... | | Authors: | Labro, A.J, Cortes, D.M, Tilegenova, C, Cuello, L.G. | | Deposit date: | 2017-12-19 | | Release date: | 2018-05-09 | | Last modified: | 2020-01-01 | | Method: | X-RAY DIFFRACTION (2.37 Å) | | Cite: | Inverted allosteric coupling between activation and inactivation gates in K+channels.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6BY2
 | | Closed and deep-inactivated conformation of KcsA-T75A mutant | | Descriptor: | Antibody Heavy Chain, Antibody Light Chain, DIACYL GLYCEROL, ... | | Authors: | Labro, A.J, Cortes, D.M, Tilegenova, C, Cuello, L.G. | | Deposit date: | 2017-12-19 | | Release date: | 2018-05-09 | | Last modified: | 2020-01-01 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Inverted allosteric coupling between activation and inactivation gates in K+channels.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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2ITC
 | | Potassium Channel KcsA-Fab complex in Sodium Chloride | | Descriptor: | Antibody Fab fragment heavy chain, Antibody Fab fragment light chain, SODIUM ION, ... | | Authors: | Lockless, S.W, Zhou, M, MacKinnon, R. | | Deposit date: | 2006-10-19 | | Release date: | 2007-05-15 | | Last modified: | 2021-10-20 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Structural and Thermodynamic Properties of Selective Ion Binding in a K(+) Channel.
Plos Biol., 5, 2007
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6CQ6
 | | K2P2.1(TREK-1) apo structure | | Descriptor: | CADMIUM ION, DECANE, POTASSIUM ION, ... | | Authors: | Lolicato, M, Minor, D.L. | | Deposit date: | 2018-03-14 | | Release date: | 2018-03-28 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site.
Nature, 547, 2017
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2HFE
 | | Rb+ complex of a K channel with an amide to ester substitution in the selectivity filter | | Descriptor: | (2S)-2-(BUTYRYLOXY)-3-HYDROXYPROPYL NONANOATE, FAB Heavy Chain, FAB Light Chain, ... | | Authors: | Valiyaveetil, F.I, MacKinnon, R, Muir, T.W. | | Deposit date: | 2006-06-23 | | Release date: | 2006-09-12 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Structural and Functional Consequences of an Amide-to-Ester Substitution in the Selectivity Filter of a Potassium Channel.
J.Am.Chem.Soc., 128, 2006
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6CQ9
 | | K2P2.1(TREK-1):ML402 complex | | Descriptor: | CADMIUM ION, HEXADECANE, N-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)PALMITAMIDE, ... | | Authors: | Lolicato, M, Minor, D.L. | | Deposit date: | 2018-03-14 | | Release date: | 2018-04-11 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site.
Nature, 547, 2017
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6CQ8
 | | K2P2.1(TREK-1):ML335 complex | | Descriptor: | CADMIUM ION, HEXADECANE, N-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)PALMITAMIDE, ... | | Authors: | Lolicato, M, Minor, D.L. | | Deposit date: | 2018-03-14 | | Release date: | 2018-03-28 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site.
Nature, 547, 2017
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6CPV
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