PDB: 159 resultsInfo pagesStatus searchChemie searchBIRD

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6YKI	Crystal structure of YTHDC1 with compound DHU_DC1_092 Descriptor: SULFATE ION, YTHDC1, ~{N}-ethyl-2-[(2~{S},5~{R})-5-methyl-2-phenyl-morpholin-4-yl]ethanamine Authors: Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A. Deposit date: 2020-04-06 Release date: 2020-07-15 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Structure-based design of ligands of the m6A-RNA reader YTHDC1 Eur J Med Chem Rep, 5, 2022
6YL0	Crystal structure of YTHDC1 with compound T_96 Descriptor: DI(HYDROXYETHYL)ETHER, SULFATE ION, YTHDC1, ... Authors: Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A. Deposit date: 2020-04-06 Release date: 2020-07-15 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Crystal structure of YTHDC1 with compound T_96 To Be Published
6YL9	Crystal structure of YTHDC1 with compound DHU_DC1_085 Descriptor: 3-[(2~{R},5~{S})-2-(2,5-dimethylphenyl)-5-methyl-morpholin-4-yl]propane-1-sulfonamide, SULFATE ION, YTHDC1 Authors: Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A. Deposit date: 2020-04-06 Release date: 2020-07-15 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Structure-based design of ligands of the m6A-RNA reader YTHDC1 Eur J Med Chem Rep, 5, 2022
6YKE	Crystal structure of YTHDC1 with compound DHU_DC1_038 Descriptor: (2~{R})-2-(3-fluorophenyl)-5,5-dimethyl-morpholine, SULFATE ION, YTHDC1 Authors: Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A. Deposit date: 2020-04-06 Release date: 2020-07-15 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.52 Å) Cite: Structure-based design of ligands of the m6A-RNA reader YTHDC1 Eur J Med Chem Rep, 5, 2022
6YKZ	Crystal structure of YTHDC1 with compound DHU_DC1_234 Descriptor: SULFATE ION, YTHDC1, ~{N}-methyl-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboxamide Authors: Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A. Deposit date: 2020-04-06 Release date: 2020-07-15 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Structure-based design of ligands of the m6A-RNA reader YTHDC1 Eur J Med Chem Rep, 5, 2022
6YNK	Crystal structure of YTHDC1 with compound DHU_DC1_068 Descriptor: 6-[[furan-2-ylmethyl(methyl)amino]methyl]-5~{H}-pyrimidine-2,4-dione, DI(HYDROXYETHYL)ETHER, SULFATE ION, ... Authors: Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A. Deposit date: 2020-04-13 Release date: 2020-07-15 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Structure-based design of ligands of the m6A-RNA reader YTHDC1 Eur J Med Chem Rep, 5, 2022
6YNN	Crystal structure of YTHDC1 with compound DHU_DC1_135 Descriptor: 6-[[(2-chloranyl-6-fluoranyl-phenyl)methyl-methyl-amino]methyl]-1~{H}-pyrimidine-2,4-dione, SULFATE ION, YTHDC1 Authors: Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A. Deposit date: 2020-04-14 Release date: 2020-07-15 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Atomistic and Thermodynamic Analysis of N6-Methyladenosine (m 6 A) Recognition by the Reader Domain of YTHDC1. J Chem Theory Comput, 17, 2021
6YOQ	Crystal structure of YTHDC1 with compound VVR_DC1_002 Descriptor: 6-methyl-~{N}-[2-(methylsulfonylamino)ethyl]-2-oxidanylidene-3~{H}-pyridine-3-carboxamide, SULFATE ION, YTHDC1 Authors: von Roten, V, Bedi, R.K, Caflisch, A. Deposit date: 2020-04-14 Release date: 2020-07-15 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Structure-based design of ligands of the m6A-RNA reader YTHDC1 Eur J Med Chem Rep, 5, 2022
6YNJ	Crystal structure of YTHDC1 with compound DHU_DC1_046 Descriptor: (2~{R})-2-(2-chlorophenyl)-5,5-dimethyl-morpholine, SULFATE ION, YTHDC1 Authors: Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A. Deposit date: 2020-04-13 Release date: 2020-07-15 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Structure-based design of ligands of the m6A-RNA reader YTHDC1 Eur J Med Chem Rep, 5, 2022
6YNM	Crystal structure of YTHDC1 with compound DHU_DC1_096 Descriptor: 1-[(2~{R},5~{S})-2-(3-chlorophenyl)-5-methyl-morpholin-4-yl]-3-methoxy-propan-2-ol, SULFATE ION, YTHDC1 Authors: Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A. Deposit date: 2020-04-14 Release date: 2020-07-15 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Structure-based design of ligands of the m6A-RNA reader YTHDC1 Eur J Med Chem Rep, 5, 2022
6YKJ	Crystal structure of YTHDC1 with compound DHU_DC1_125 Descriptor: SULFATE ION, YTHDC1, ~{N}-methyl-4-(methylamino)pyridine-2-carboxamide Authors: Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A. Deposit date: 2020-04-06 Release date: 2020-07-15 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structure-based design of ligands of the m6A-RNA reader YTHDC1 Eur J Med Chem Rep, 5, 2022
6YNI	Crystal structure of YTHDC1 with compound DHU_DC1_036 Descriptor: (2~{R},3~{R})-2-(3-chlorophenyl)-3,5,5-trimethyl-morpholine, SULFATE ION, YTHDC1 Authors: Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A. Deposit date: 2020-04-13 Release date: 2020-07-15 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.36 Å) Cite: Structure-based design of ligands of the m6A-RNA reader YTHDC1 Eur J Med Chem Rep, 5, 2022
6YNL	Crystal structure of YTHDC1 with compound DHU_DC1_078 Descriptor: 3-[(2~{R})-5,5-dimethyl-2-phenyl-morpholin-4-yl]-~{N}-(methylcarbamoyl)propanamide, SULFATE ION, YTHDC1 Authors: Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A. Deposit date: 2020-04-14 Release date: 2020-07-15 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Structure-based design of ligands of the m6A-RNA reader YTHDC1 Eur J Med Chem Rep, 5, 2022
6YNP	Crystal structure of YTHDC1 with compound T96C1 Descriptor: CHLORIDE ION, SULFATE ION, YTHDC1, ... Authors: Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A. Deposit date: 2020-04-14 Release date: 2020-07-15 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.1 Å) Cite: Structure-based design of ligands of the m6A-RNA reader YTHDC1 Eur J Med Chem Rep, 5, 2022
6YL8	Crystal structure of YTHDC1 with compound DHU_DC1_011 Descriptor: (2~{R},5~{S})-2-(2-chlorophenyl)-5-methyl-morpholine, SULFATE ION, YTHDC1 Authors: Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A. Deposit date: 2020-04-06 Release date: 2020-07-15 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Structure-based design of ligands of the m6A-RNA reader YTHDC1 Eur J Med Chem Rep, 5, 2022
6YNO	Crystal structure of YTHDC1 with compound DHU_DC1_139 Descriptor: 6-[[methyl-[(1-phenylpyrazol-3-yl)methyl]amino]methyl]-1~{H}-pyrimidine-2,4-dione, SULFATE ION, YTHDC1 Authors: Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A. Deposit date: 2020-04-14 Release date: 2020-07-15 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Atomistic and Thermodynamic Analysis of N6-Methyladenosine (m 6 A) Recognition by the Reader Domain of YTHDC1. J Chem Theory Comput, 17, 2021
6YM2	Crystal structure of YTHDC1 with compound ADO_AC_25 Descriptor: SULFATE ION, YTHDC1, ~{N},9-dimethylpurin-6-amine Authors: Bedi, R.K, Li, Y, Dolbois, A, Wiedmer, L, Caflisch, A. Deposit date: 2020-04-07 Release date: 2021-04-14 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Crystal structure of YTHDC1 with compound ADO_AC_25 To Be Published
6YM8	Crystal structure of YTHDC1 with compound YLI_DC1_002 Descriptor: 2-chloranyl-~{N}-methyl-9~{H}-purin-6-amine, SULFATE ION, YTHDC1 Authors: Bedi, R.K, Li, Y, Wiedmer, L, Caflisch, A. Deposit date: 2020-04-07 Release date: 2021-04-14 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Crystal structure of YTHDC1 with compound YLI_DC1_002 To Be Published
6ZD9	Crystal structure of YTHDC1 apo purified using GST tag Descriptor: DI(HYDROXYETHYL)ETHER, SULFATE ION, YTHDC1 Authors: Bedi, R.K, Caflisch, A. Deposit date: 2020-06-14 Release date: 2020-07-29 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.51 Å) Cite: Atomistic and Thermodynamic Analysis of N6-Methyladenosine (m 6 A) Recognition by the Reader Domain of YTHDC1. J Chem Theory Comput, 17, 2021
6ZCN	Crystal structure of YTHDC1 with m6A Descriptor: N6-METHYLADENOSINE-5'-MONOPHOSPHATE, SULFATE ION, YTHDC1 Authors: Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A. Deposit date: 2020-06-11 Release date: 2020-07-29 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Atomistic and Thermodynamic Analysis of N6-Methyladenosine (m 6 A) Recognition by the Reader Domain of YTHDC1. J Chem Theory Comput, 17, 2021
6ZCM	Crystal structure of YTHDC1 with compound DHU_DC1_180 Descriptor: 6-[[cyclopropyl-[(7-methoxy-1,3-benzodioxol-5-yl)methyl]amino]methyl]-1~{H}-pyrimidine-2,4-dione, SULFATE ION, YTHDC1 Authors: Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A. Deposit date: 2020-06-11 Release date: 2020-07-29 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.24 Å) Cite: Atomistic and Thermodynamic Analysis of N6-Methyladenosine (m 6 A) Recognition by the Reader Domain of YTHDC1. J Chem Theory Comput, 17, 2021
6ZOT	Crystal structure of YTHDF3 YTH domain in complex with m6A RNA Descriptor: RNA, YTH domain-containing family protein 3 Authors: Bedi, R.K, Caflisch, A. Deposit date: 2020-07-07 Release date: 2020-10-28 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structural and Dynamic Insights into Redundant Function of YTHDF Proteins. J.Chem.Inf.Model., 60, 2020
7A1V	Crystal structure of YTHDF2 in complex with m1A Descriptor: 6-AMINO-1-METHYLPURINE, GLYCEROL, SULFATE ION, ... Authors: Wang, X, Caflisch, A. Deposit date: 2020-08-14 Release date: 2021-08-25 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal structure of YTHDF2 in complex with m1A To Be Published
8Q33	Crystal structure of YTHDC1 in complex with Compound 15 (ZA_343) Descriptor: SULFATE ION, YTH domain-containing protein 1, ~{N}-[2-[[2-chloranyl-6-(methylamino)purin-9-yl]methyl]phenyl]-2,2,2-tris(fluoranyl)ethanamide Authors: Bedi, R.K, Zalesak, F, Caflisch, A. Deposit date: 2023-08-03 Release date: 2023-12-06 Method: X-RAY DIFFRACTION (1.43 Å) Cite: Crystal structure of YTHDC1 in complex with Compound 15 (ZA_343) To Be Published
8Q4R	Crystal structure of YTHDC1 in complex with Compound 30 (ZA_326) Descriptor: SULFATE ION, YTH domain-containing protein 1, [4-[[2-chloranyl-6-(methylamino)purin-9-yl]methyl]phenyl]methanol Authors: Bedi, R.K, Zalesak, F, Caflisch, A. Deposit date: 2023-08-07 Release date: 2023-12-06 Method: X-RAY DIFFRACTION (1.43 Å) Cite: Crystal structure of YTHDC1 in complex with Compound 30 (ZA_326) To Be Published

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