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4IWV	Crystals structure of Human Glucokinase in complex with small molecule activator Descriptor: (2S)-2-{[1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxy}-N-(5-chloropyridin-2-yl)-3-(2-hydroxyethoxy)propanamide, Glucokinase isoform 3, SODIUM ION, ... Authors: Ogg, D.J, Hargreaves, D, Gerhardt, S, Flavell, L, McAlister, M. Deposit date: 2013-01-24 Release date: 2013-04-24 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Optimising pharmacokinetics of glucokinase activators with matched triplicate design sets the discovery of AZD3651 and AZD9485 To be Published
4ISG	Human glucokinase in complex with novel activator (2S)-3-cyclohexyl-2-[4-(methylsulfonyl)-2-oxopiperazin-1-yl]-N-(1,3-thiazol-2-yl)propanamide Descriptor: (2S)-3-cyclohexyl-2-[4-(methylsulfonyl)-2-oxopiperazin-1-yl]-N-(1,3-thiazol-2-yl)propanamide, Glucokinase, IODIDE ION, ... Authors: Hosfield, D, Skene, R.J. Deposit date: 2013-01-16 Release date: 2013-03-20 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.645 Å) Cite: Design, synthesis and SAR of novel glucokinase activators. Bioorg.Med.Chem.Lett., 23, 2013
4JAX	Crystal structure of dimeric KlHxk1 in crystal form X Descriptor: GLYCEROL, Hexokinase, PHOSPHATE ION Authors: Kuettner, E.B, Strater, N, Kettner, K, Otto, A, Lilie, H, Golbik, R.P, Kriegel, T.M. Deposit date: 2013-02-19 Release date: 2013-05-01 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.26 Å) Cite: In vivo phosphorylation and in vitro autophosphorylation-inactivation of Kluyveromyces lactis hexokinase KlHxk1. Biochem.Biophys.Res.Commun., 435, 2013
4L3Q	Crystal structure of glucokinase-activator complex Descriptor: 6-{3-[(1-methyl-1H-imidazol-2-yl)sulfanyl]phenyl}pyridin-2(1H)-one, Glucokinase, alpha-D-glucopyranose Authors: Gajiwala, K.S, Filipski, K.J. Deposit date: 2013-06-06 Release date: 2013-07-24 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Pyrimidone-based series of glucokinase activators with alternative donor-acceptor motif. Bioorg.Med.Chem.Lett., 23, 2013
4LC9	Structural Basis for Regulation of Human Glucokinase by Glucokinase Regulatory Protein Descriptor: 6-O-phosphono-beta-D-fructofuranose, Glucokinase, Glucokinase regulatory protein, ... Authors: Beck, T, Miller, B.G. Deposit date: 2013-06-21 Release date: 2013-09-04 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.4 Å) Cite: Structural basis for regulation of human glucokinase by glucokinase regulatory protein. Biochemistry, 52, 2013
4MLE	Human Glucokinase in Complex with Novel Amino Thiazole Activator Descriptor: 3-(benzyloxy)-N-(4-methyl-1,3-thiazol-2-yl)pyridin-2-amine, Glucokinase, alpha-D-glucopyranose Authors: Voegtli, W.C. Deposit date: 2013-09-06 Release date: 2013-09-25 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Identification of a New Class of Glucokinase Activators through Structure-Based Design. J.Med.Chem., 56, 2013
4MLH	Human Glucokinase in Complex with a Novel Amino Thiazole Allosteric Activator Descriptor: 3-(benzyloxy)-5-methyl-N-(4-methyl-1,3-thiazol-2-yl)pyridin-2-amine, Glucokinase, alpha-D-glucopyranose Authors: Voegtli, W.C. Deposit date: 2013-09-06 Release date: 2013-09-25 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Identification of a New Class of Glucokinase Activators through Structure-Based Design. J.Med.Chem., 56, 2013

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