8I69
| Crystal structure of Mycobacterium tuberculosis Uracil-DNA glycosylase in complex with 5-Fluoroorotic acid and Citric acid, Form I | Descriptor: | 1,2-ETHANEDIOL, 5-FLUORO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, CITRIC ACID, ... | Authors: | Raj, P, Paul, A, Gopal, B. | Deposit date: | 2023-01-27 | Release date: | 2023-07-12 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structures of non-uracil ring fragments in complex with Mycobacterium tuberculosis uracil DNA glycosylase (MtUng) as a starting point for novel inhibitor design: A case study with the barbituric acid fragment. Eur.J.Med.Chem., 258, 2023
|
|
8I6D
| Crystal structure of Mycobacterium tuberculosis Uracil-DNA glycosylase in complex with 5-Hydroxy-2,4(1H,3H)-pyrimidinedione, Form VI | Descriptor: | 1,2-ETHANEDIOL, 5-oxidanyl-1~{H}-pyrimidine-2,4-dione, DI(HYDROXYETHYL)ETHER, ... | Authors: | Raj, P, Paul, A, Gopal, B. | Deposit date: | 2023-01-27 | Release date: | 2023-07-12 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structures of non-uracil ring fragments in complex with Mycobacterium tuberculosis uracil DNA glycosylase (MtUng) as a starting point for novel inhibitor design: A case study with the barbituric acid fragment. Eur.J.Med.Chem., 258, 2023
|
|
8I6B
| Crystal structure of Mycobacterium tuberculosis Uracil-DNA glycosylase in complex with 5-Hydroxy-2,4(1H,3H)-pyrimidinedione, Form I | Descriptor: | 1,2-ETHANEDIOL, 5-oxidanyl-1~{H}-pyrimidine-2,4-dione, CHLORIDE ION, ... | Authors: | Raj, P, Paul, A, Gopal, B. | Deposit date: | 2023-01-27 | Release date: | 2023-07-12 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystal structures of non-uracil ring fragments in complex with Mycobacterium tuberculosis uracil DNA glycosylase (MtUng) as a starting point for novel inhibitor design: A case study with the barbituric acid fragment. Eur.J.Med.Chem., 258, 2023
|
|
8AIN
| MCUGI SAUNG complex | Descriptor: | 1,2-ETHANEDIOL, MCUGI, SULFATE ION, ... | Authors: | Muselmani, W, Savva, R. | Deposit date: | 2022-07-26 | Release date: | 2023-06-21 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | A Multimodal Approach towards Genomic Identification of Protein Inhibitors of Uracil-DNA Glycosylase. Viruses, 15, 2023
|
|
8AIL
| Bacillus phage VMY22 p56 in complex with Bacillus weidmannii Ung | Descriptor: | Bacillus phage VMY22 p56, GLYCEROL, IODIDE ION, ... | Authors: | Muselmani, W, Bagneris, C, Savva, R. | Deposit date: | 2022-07-26 | Release date: | 2023-06-21 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | A Multimodal Approach towards Genomic Identification of Protein Inhibitors of Uracil-DNA Glycosylase. Viruses, 15, 2023
|
|
8AIM
| Ugi-2 SAUNG complex | Descriptor: | Uracil-DNA glycosylase, Uracil-DNA glycosylase inhibitor | Authors: | Muselmani, W, Savva, R. | Deposit date: | 2022-07-26 | Release date: | 2023-06-21 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | A Multimodal Approach towards Genomic Identification of Protein Inhibitors of Uracil-DNA Glycosylase. Viruses, 15, 2023
|
|
7V7C
| CryoEM structure of DDB1-VprBP-Vpr-UNG2(94-313) complex | Descriptor: | DDB1- and CUL4-associated factor 1, DNA damage-binding protein 1, Protein Vpr, ... | Authors: | Wang, D, Xu, J, Liu, Q, Xiang, Y. | Deposit date: | 2021-08-21 | Release date: | 2022-08-31 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structural insights into the HIV-1 Vpr mediated ubiquitination through the Cullin-RING E3 ubiquitin ligase To Be Published
|
|
6LYV
| The crystal structure of SAUGI/KSHVUDG complex | Descriptor: | SAUGI, Uracil-DNA glycosylase | Authors: | Liao, Y.T, Ko, T.P, Wang, H.C. | Deposit date: | 2020-02-16 | Release date: | 2020-06-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural insight into the differential interactions between the DNA mimic protein SAUGI and two gamma herpesvirus uracil-DNA glycosylases. Int.J.Biol.Macromol., 160, 2020
|
|
6LYJ
| The crystal structure of SAUGI/EBVUDG complex | Descriptor: | SAUGI, Uracil-DNA glycosylase | Authors: | Liao, Y.T, Ko, T.P, Wang, H.C. | Deposit date: | 2020-02-14 | Release date: | 2020-06-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural insight into the differential interactions between the DNA mimic protein SAUGI and two gamma herpesvirus uracil-DNA glycosylases. Int.J.Biol.Macromol., 160, 2020
|
|
6LYD
| Crystal Structure of mimivirus UNG Y322L in complex with UGI | Descriptor: | Probable uracil-DNA glycosylase, Uracil-DNA glycosylase inhibitor | Authors: | Pathak, D, Kwon, E, Kim, D.Y. | Deposit date: | 2020-02-14 | Release date: | 2020-07-08 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.598 Å) | Cite: | Selective interactions between mimivirus uracil-DNA glycosylase and inhibitory proteins determined by a single amino acid. J.Struct.Biol., 211, 2020
|
|
6LYE
| Crystal Structure of mimivirus UNG Y322F in complex with UGI | Descriptor: | Probable uracil-DNA glycosylase, Uracil-DNA glycosylase inhibitor | Authors: | Pathak, D, Kwon, E, Kim, D.Y. | Deposit date: | 2020-02-14 | Release date: | 2020-07-08 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Selective interactions between mimivirus uracil-DNA glycosylase and inhibitory proteins determined by a single amino acid. J.Struct.Biol., 211, 2020
|
|
6VBA
| Structure of human Uracil DNA Glycosylase (UDG) bound to Aurintricarboxylic acid (ATA) | Descriptor: | 3,3'-[(3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)methylene]bis(6-hydroxybenzoic acid), Uracil-DNA glycosylase | Authors: | Moiani, D, Arvai, A.S, Tainer, J.A. | Deposit date: | 2019-12-18 | Release date: | 2021-03-03 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation. Prog.Biophys.Mol.Biol., 163, 2021
|
|
6L6S
| The structure of the UdgX mutant H109E crosslinked to single-stranded DNA | Descriptor: | DNA (5'-D(P*TP*GP*(ORP)P*AP*GP*GP*CP*AP*TP*GP*C)-3'), IRON/SULFUR CLUSTER, Phage SPO1 DNA polymerase-related protein | Authors: | Xie, W, Tu, J, Zeng, H. | Deposit date: | 2019-10-29 | Release date: | 2020-11-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.06425953 Å) | Cite: | Structural insights into an MsmUdgX mutant capable of both crosslinking and uracil excision capability. DNA Repair (Amst), 97, 2021
|
|
6L5B
| The structure of the UdgX mutant H109E at a post-excision state | Descriptor: | IRON/SULFUR CLUSTER, Uracil DNA glycosylase superfamily protein | Authors: | Xie, W, Tu, J, Zeng, H. | Deposit date: | 2019-10-22 | Release date: | 2020-10-28 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.00004983 Å) | Cite: | Structural insights into an MsmUdgX mutant capable of both crosslinking and uracil excision capability. DNA Repair (Amst), 97, 2021
|
|
6L5A
| The structure of the UdgX mutant H109E at a pre-excision state | Descriptor: | GLYCEROL, IRON/SULFUR CLUSTER, Uracil DNA glycosylase superfamily protein | Authors: | Xie, W, Tu, J, Zeng, H. | Deposit date: | 2019-10-22 | Release date: | 2020-10-28 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.80007327 Å) | Cite: | Structural insights into an MsmUdgX mutant capable of both crosslinking and uracil excision capability. DNA Repair (Amst), 97, 2021
|
|
6U17
| Human thymine DNA glycosylase bound to DNA with 2'-F-5-carboxyl-dC substrate analog | Descriptor: | ACETATE ION, DNA (28-MER), DNA (30-MER), ... | Authors: | Pidugu, L.S, Pozharski, E, Drohat, A.C. | Deposit date: | 2019-08-15 | Release date: | 2019-11-20 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Excision of 5-Carboxylcytosine by Thymine DNA Glycosylase. J.Am.Chem.Soc., 141, 2019
|
|
6U15
| |
6U16
| Human thymine DNA glycosylase N140A mutant bound to DNA with 5-carboxyl-dC substrate | Descriptor: | 1,2-ETHANEDIOL, DNA (28-MER), G/T mismatch-specific thymine DNA glycosylase | Authors: | Pidugu, L.S, Pozharski, E, Drohat, A.C. | Deposit date: | 2019-08-15 | Release date: | 2019-11-20 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Excision of 5-Carboxylcytosine by Thymine DNA Glycosylase. J.Am.Chem.Soc., 141, 2019
|
|
6IO9
| The structure of apo-UdgX | Descriptor: | IRON/SULFUR CLUSTER, Phage SPO1 DNA polymerase-related protein, SULFATE ION | Authors: | Xie, W, Tu, J. | Deposit date: | 2018-10-29 | Release date: | 2019-07-24 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Suicide inactivation of the uracil DNA glycosylase UdgX by covalent complex formation. Nat.Chem.Biol., 15, 2019
|
|
6IOB
| The structure of the H109A mutant of UdgX in complex with uracil | Descriptor: | IRON/SULFUR CLUSTER, Phage SPO1 DNA polymerase-related protein, URACIL | Authors: | Xie, W, Tu, J. | Deposit date: | 2018-10-29 | Release date: | 2019-07-24 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.002 Å) | Cite: | Suicide inactivation of the uracil DNA glycosylase UdgX by covalent complex formation. Nat.Chem.Biol., 15, 2019
|
|
6IOD
| The structure of UdgX in complex with single-stranded DNA | Descriptor: | DNA, IRON/SULFUR CLUSTER, Phage SPO1 DNA polymerase-related protein | Authors: | Xie, W, Tu, J. | Deposit date: | 2018-10-29 | Release date: | 2019-07-31 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.66 Å) | Cite: | Suicide inactivation of the uracil DNA glycosylase UdgX by covalent complex formation. Nat.Chem.Biol., 15, 2019
|
|
6IOA
| The structure of UdgX in complex with uracil | Descriptor: | IRON/SULFUR CLUSTER, Phage SPO1 DNA polymerase-related protein, SULFATE ION, ... | Authors: | Xie, W, Tu, J. | Deposit date: | 2018-10-29 | Release date: | 2019-07-24 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Suicide inactivation of the uracil DNA glycosylase UdgX by covalent complex formation. Nat.Chem.Biol., 15, 2019
|
|
6IOC
| The structure of the H109Q mutant of UdgX in complex with uracil | Descriptor: | IRON/SULFUR CLUSTER, Phage SPO1 DNA polymerase-related protein, URACIL | Authors: | Xie, W, Tu, J. | Deposit date: | 2018-10-29 | Release date: | 2019-07-24 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.624 Å) | Cite: | Suicide inactivation of the uracil DNA glycosylase UdgX by covalent complex formation. Nat.Chem.Biol., 15, 2019
|
|
6AJR
| Complex form of Uracil DNA glycosylase X and uracil | Descriptor: | IRON/SULFUR CLUSTER, URACIL, Uracil DNA glycosylase superfamily protein | Authors: | Ahn, W.C, Aroli, S, Varshney, U, Woo, E.J. | Deposit date: | 2018-08-28 | Release date: | 2019-05-29 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.341 Å) | Cite: | Covalent binding of uracil DNA glycosylase UdgX to abasic DNA upon uracil excision. Nat.Chem.Biol., 15, 2019
|
|
6AJO
| Complex form of Uracil DNA glycosylase X and uracil-DNA. | Descriptor: | DNA (5'-D(P*(ORP)P*TP*T)-3'), IRON/SULFUR CLUSTER, PHOSPHATE ION, ... | Authors: | Ahn, W.C, Aroli, S, Varshney, U, Woo, E.J. | Deposit date: | 2018-08-28 | Release date: | 2019-05-29 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.269 Å) | Cite: | Covalent binding of uracil DNA glycosylase UdgX to abasic DNA upon uracil excision. Nat.Chem.Biol., 15, 2019
|
|