2B7B
 
 | | Yeast guanine nucleotide exchange factor eEF1Balpha K205A mutant in complex with eEF1A and GDP | | Descriptor: | Elongation factor 1-alpha, GUANOSINE-5'-DIPHOSPHATE, elongation factor-1 beta | | Authors: | Pittman, Y.R, Valente, L, Jeppesen, M.G, Andersen, G.R, Patel, S, Kinzy, T.G. | | Deposit date: | 2005-10-04 | | Release date: | 2006-05-02 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Mg2+ and a key lysine modulate exchange activity of eukaryotic translation elongation factor 1B alpha
J.Biol.Chem., 281, 2006
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1B23
 | | E. coli cysteinyl-tRNA and T. aquaticus elongation factor EF-TU:GTP ternary complex | | Descriptor: | CYSTEINE, CYSTEINYL TRNA, ELONGATION FACTOR TU, ... | | Authors: | Nissen, P, Kjeldgaard, M, Thirup, S, Nyborg, J. | | Deposit date: | 1998-12-04 | | Release date: | 1998-12-07 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | The crystal structure of Cys-tRNACys-EF-Tu-GDPNP reveals general and specific features in the ternary complex and in tRNA.
Structure Fold.Des., 7, 1999
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8RDV
 | | Cryo-EM structure of P. urativorans 70S ribosome in complex with hibernation factor Balon, mRNA and P-site tRNA (structure 2). | | Descriptor: | 16S rRNA, 23S rRNA, 5S rRNA, ... | | Authors: | Helena-Bueno, K, Rybak, M.Y, Gagnon, M.G, Hill, C.H, Melnikov, S.V. | | Deposit date: | 2023-12-08 | | Release date: | 2024-02-21 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | A new family of bacterial ribosome hibernation factors.
Nature, 626, 2024
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3AVW
 | | Structure of viral RNA polymerase complex 4 | | Descriptor: | 3'-DEOXY-GUANOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Elongation factor Ts, ... | | Authors: | Takeshita, D, Tomita, K. | | Deposit date: | 2011-03-08 | | Release date: | 2012-01-18 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.602 Å) | | Cite: | Molecular basis for RNA polymerization by Q beta replicase
Nat.Struct.Mol.Biol., 19, 2012
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3VNV
 | | Complex structure of viral RNA polymerase II | | Descriptor: | 3'-DEOXY-CYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, Elongation factor Ts, ... | | Authors: | Takeshita, D, Tomita, K. | | Deposit date: | 2012-01-18 | | Release date: | 2012-08-08 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.604 Å) | | Cite: | Mechanism for template-independent terminal adenylation activity of Q beta replicase
Structure, 20, 2012
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3AVT
 | | Structure of viral RNA polymerase complex 1 | | Descriptor: | 3'-DEOXY-GUANOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Elongation factor Ts, ... | | Authors: | Takeshita, D, Tomita, K. | | Deposit date: | 2011-03-08 | | Release date: | 2012-01-18 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.607 Å) | | Cite: | Molecular basis for RNA polymerization by Q beta replicase
Nat.Struct.Mol.Biol., 19, 2012
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3AVY
 | | Structure of viral RNA polymerase complex 6 | | Descriptor: | 3'-DEOXY-CYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, Elongation factor Ts, ... | | Authors: | Takeshita, D, Tomita, K. | | Deposit date: | 2011-03-08 | | Release date: | 2012-01-18 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.616 Å) | | Cite: | Molecular basis for RNA polymerization by Q beta replicase
Nat.Struct.Mol.Biol., 19, 2012
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8RD8
 | | Cryo-EM structure of P. urativorans 70S ribosome in complex with hibernation factors Balon and RaiA (structure 1). | | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S30, ... | | Authors: | Helena-Bueno, K, Rybak, M.Y, Gagnon, M.G, Hill, C.H, Melnikov, S.V. | | Deposit date: | 2023-12-07 | | Release date: | 2024-02-21 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (2.62 Å) | | Cite: | A new family of bacterial ribosome hibernation factors.
Nature, 626, 2024
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8G5Z
 | | mRNA decoding in human is kinetically and structurally distinct from bacteria (GA state) | | Descriptor: | 1,4-DIAMINOBUTANE, 18S rRNA, 28S rRNA, ... | | Authors: | Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Altman, R.B, Blanchard, S.C. | | Deposit date: | 2023-02-14 | | Release date: | 2023-04-19 | | Last modified: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (2.64 Å) | | Cite: | mRNA decoding in human is kinetically and structurally distinct from bacteria.
Nature, 617, 2023
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4LBY
 | | Identifying ligand binding hot spots in proteins using brominated fragments | | Descriptor: | AMMONIUM ION, Elongation factor Tu-A, MAGNESIUM ION, ... | | Authors: | Groftehauge, M.K, Therkelsen, M, Taaning, R, Skrydstrup, T, Morth, J.P, Nissen, P. | | Deposit date: | 2013-06-21 | | Release date: | 2013-09-11 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.692 Å) | | Cite: | Identifying ligand-binding hot spots in proteins using brominated fragments.
Acta Crystallogr.,Sect.F, 69, 2013
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4IW3
 | | Crystal structure of a Pseudomonas putida prolyl-4-hydroxylase (P4H) in complex with elongation factor Tu (EF-Tu) | | Descriptor: | Elongation factor Tu-A, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Scotti, J.S, McDonough, M.A, Schofield, C.J. | | Deposit date: | 2013-01-23 | | Release date: | 2014-01-29 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.697 Å) | | Cite: | Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation
Proc.Natl.Acad.Sci.USA, 111, 2014
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3U2Q
 | | EF-Tu (Escherichia coli) in complex with NVP-LFF571 | | Descriptor: | Elongation factor Tu 1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Palestrant, D.J. | | Deposit date: | 2011-10-04 | | Release date: | 2012-05-02 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Discovery of LFF571: an investigational agent for Clostridium difficile infection.
J.Med.Chem., 55, 2012
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1EFM
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8QFS
 | | Cryo-EM structure of SidH from Legionella pneumophila | | Descriptor: | Elongation factor Tu, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Sharma, R, Weis, F, Bhogaraju, S. | | Deposit date: | 2023-09-04 | | Release date: | 2023-10-11 | | Last modified: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Structural basis for the toxicity of Legionella pneumophila effector SidH.
Nat Commun, 14, 2023
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6RA9
 | | Novel structural features and post-translational modifications in eukaryotic elongation factor 1A2 from Oryctolagus cuniculus | | Descriptor: | Elongation factor 1-alpha 2, GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Carriles, A.A, Hermoso, J, Gago, F. | | Deposit date: | 2019-04-05 | | Release date: | 2020-06-03 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural Cues for Understanding eEF1A2 Moonlighting.
Chembiochem, 22, 2021
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1TUI
 | | INTACT ELONGATION FACTOR TU IN COMPLEX WITH GDP | | Descriptor: | ELONGATION FACTOR TU, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | | Authors: | Polekhina, G, Thirup, S, Kjeldgaard, M, Nissen, P, Lippmann, C, Nyborg, J. | | Deposit date: | 1996-05-23 | | Release date: | 1997-06-05 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Helix unwinding in the effector region of elongation factor EF-Tu-GDP.
Structure, 4, 1996
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1TTT
 | | Phe-tRNA, elongation factoR EF-TU:GDPNP ternary complex | | Descriptor: | MAGNESIUM ION, OF ELONGATION FACTOR TU (EF-TU), PHENYLALANINE, ... | | Authors: | Nissen, P, Kjeldgaard, M, Thirup, S, Polekhina, G, Reshetnikova, L, Clark, B.F.C, Nyborg, J. | | Deposit date: | 1995-11-16 | | Release date: | 1996-12-23 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Crystal structure of the ternary complex of Phe-tRNAPhe, EF-Tu, and a GTP analog.
Science, 270, 1995
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4C0S
 | | Mammalian translation elongation factor eEF1A2 | | Descriptor: | ELONGATION FACTOR 1-ALPHA 2, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | | Authors: | Crepin, T, Shalak, V.F, Yaremchuk, A.D, Vlasenko, D.O, McCarthy, A.A, Negrutskii, B.S, Tukalo, M.A, El'skaya, A.V. | | Deposit date: | 2013-08-07 | | Release date: | 2014-08-27 | | Last modified: | 2017-01-25 | | Method: | X-RAY DIFFRACTION (2.703 Å) | | Cite: | Mammalian Translation Elongation Factor Eef1A2: X-Ray Structure and New Features of Gdp/GTP Exchange Mechanism in Higher Eukaryotes
Nucleic Acids Res., 42, 2014
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8RDW
 | | Cryo-EM structure of P. urativorans 70S ribosome in complex with hibernation factor Balon and EF-Tu(GDP) (structure 3). | | Descriptor: | 16S rRNA, 23S rRNA, 5S rRNA, ... | | Authors: | Helena-Bueno, K, Rybak, M.Y, Gagnon, M.G, Hill, C.H, Melnikov, S.V. | | Deposit date: | 2023-12-08 | | Release date: | 2024-02-21 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (2.74 Å) | | Cite: | A new family of bacterial ribosome hibernation factors.
Nature, 626, 2024
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5OPD
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7VMX
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8G6J
 | | mRNA decoding in human is kinetically and structurally distinct from bacteria (GA state 2) | | Descriptor: | (3R,6R,9S,12S,15S,18S,20R,24aR)-6-[(2S)-butan-2-yl]-3,12-bis[(1R)-1-hydroxy-2-methylpropyl]-8,9,11,17,18-pentamethyl-15-[(2S)-2-methylbutyl]hexadecahydropyrido[1,2-a][1,4,7,10,13,16,19]heptaazacyclohenicosine-1,4,7,10,13,16,19(21H)-heptone, (3beta)-O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine, 1,4-DIAMINOBUTANE, ... | | Authors: | Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Altman, R.B, Blanchard, S.C. | | Deposit date: | 2023-02-15 | | Release date: | 2023-04-19 | | Last modified: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | mRNA decoding in human is kinetically and structurally distinct from bacteria.
Nature, 617, 2023
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5MI3
 | | Structure of phosphorylated translation elongation factor EF-Tu from E. coli | | Descriptor: | Elongation factor Tu 1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | | Authors: | Talavera, A, Hendrix, J, Versees, W, De Gieter, S, Castro-Roa, D, Jurenas, D, Van Nerom, K, Vandenberk, N, Barth, A, De Greve, H, Hofkens, J, Zenkin, N, Loris, R, Garcia-Pino, A. | | Deposit date: | 2016-11-27 | | Release date: | 2017-12-20 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Phosphorylation decelerates conformational dynamics in bacterial translation elongation factors.
Sci Adv, 4, 2018
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3AGP
 | | Structure of viral polymerase form I | | Descriptor: | CALCIUM ION, Elongation factor Ts, Elongation factor Tu, ... | | Authors: | Takeshita, D, Tomita, K. | | Deposit date: | 2010-04-06 | | Release date: | 2010-09-01 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Assembly of Q{beta} viral RNA polymerase with host translational elongation factors EF-Tu and -Ts
Proc.Natl.Acad.Sci.USA, 107, 2010
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2HDN
 | | Trypsin-modified Elongation Factor Tu in complex with tetracycline at 2.8 Angstrom resolution | | Descriptor: | Elongation factor EF-Tu, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Mui, S, Heffron, S.E, Aorora, A, Abel, K, Bergmann, E, Jurnak, F. | | Deposit date: | 2006-06-20 | | Release date: | 2006-10-31 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Molecular complementarity between tetracycline and the GTPase active site of elongation factor Tu.
Acta Crystallogr.,Sect.D, 62, 2006
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