PDB: 145 resultsInfo pagesStatus searchChemie searchBIRD

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6PAV	Structure of Human NMT1 with products CoA and myristoyl-lysine peptide with acetylated N-terminus Descriptor: ARF6 peptide, COENZYME A, GLYCEROL, ... Authors: Price, I.R, Lin, H. Deposit date: 2019-06-12 Release date: 2020-03-11 Method: X-RAY DIFFRACTION (2.52 Å) Cite: NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle. Nat Commun, 11, 2020
8HBS	Crystal of rAlfNmt Descriptor: Glycylpeptide N-tetradecanoyltransferase Authors: Wang, Y, Wang, S. Deposit date: 2022-10-30 Release date: 2023-03-08 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.78 Å) Cite: N -Myristoyltransferase, a Potential Antifungal Candidate Drug-Target for Aspergillus flavus. Microbiol Spectr, 11, 2023
7RK3	Crystal structure of human N-myristoyltransferase 1 fragment (residues 109-496) bound to diacylated human Arf6 octapeptide and Coenzyme A Descriptor: 4'-diphospho pantetheine, ADP-ribosylation factor 6, Glycylpeptide N-tetradecanoyltransferase 1, ... Authors: Fenwick, M.K, Lin, H. Deposit date: 2021-07-21 Release date: 2022-07-27 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Crystal structure of human N-myristoyltransferase 1 fragment (residues 109-496) bound to diacylated human Arf6 octapeptide and Coenzyme A To Be Published
6PAU	Structure of Human NMT2 with myristoyl-lysine peptide and CoA products Descriptor: 4'-diphospho pantetheine, Arf6 peptide, GLYCEROL, ... Authors: Price, I.R, Lin, H. Deposit date: 2019-06-11 Release date: 2020-03-11 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.93 Å) Cite: NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle. Nat Commun, 11, 2020
4UCM	CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A FRAGMENT Descriptor: GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, TETRADECANOYL-COA, methyl-3-methyl-5-phenyl-2H-pyrazol-4-methyl amine Authors: Robinson, D.A, Wyatt, P.G. Deposit date: 2014-12-04 Release date: 2015-05-13 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.32 Å) Cite: Identification and Structure Solution of Fragment Hits Against Kinetoplastid N-Myristoyltransferase Acta Crystallogr.,Sect.F, 71, 2015
4UFW	Plasmodium vivax N-myristoyltransferase in complex with a pyridyl inhibitor (compound 22) Descriptor: 2-oxopentadecyl-CoA, 4-chloranyl-N-[2-(3-methoxyphenyl)ethanimidoyl]-2-piperidin-4-yloxy-benzamide, CHLORIDE ION, ... Authors: Yu, Z, Brannigan, J.A, Rangachari, K, Heal, W.P, Wilkinson, A.J, Holder, A.A, Tate, E.W, Leatherbarrow, R.J. Deposit date: 2015-03-19 Release date: 2016-02-03 Last modified: 2016-04-20 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Discovery of Pyridyl-Based Inhibitors of Plasmodium Falciparum N-Myristoyltransferase Medchemcomm, 6, 2015
4UFX	Plasmodium vivax N-myristoyltransferase in complex with a pyridyl inhibitor (compound 19) Descriptor: 2-oxopentadecyl-CoA, CHLORIDE ION, DIMETHYL SULFOXIDE, ... Authors: Yu, Z, Brannigan, J.A, Rangachari, K, Heal, W.P, Wilkinson, A.J, Holder, A.A, Tate, E.W, Leatherbarrow, R.J. Deposit date: 2015-03-19 Release date: 2016-02-03 Last modified: 2016-04-20 Method: X-RAY DIFFRACTION (1.49 Å) Cite: Discovery of Pyridyl-Based Inhibitors of Plasmodium Falciparum N-Myristoyltransferase Medchemcomm, 6, 2015
6QDB	Leishmania major N-myristoyltransferase in complex with thienopyrimidine inhibitor IMP-0000081 Descriptor: 3-[methyl-[2-[methyl(piperidin-4-yl)amino]thieno[3,2-d]pyrimidin-4-yl]amino]propanenitrile, Glycylpeptide N-tetradecanoyltransferase, MAGNESIUM ION, ... Authors: Brannigan, J.A. Deposit date: 2019-01-01 Release date: 2020-05-06 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Novel Thienopyrimidine Inhibitors of Leishmania N -Myristoyltransferase with On-Target Activity in Intracellular Amastigotes. J.Med.Chem., 63, 2020
4UFV	Plasmodium vivax N-myristoyltransferase in complex with a pyridyl inhibitor (compound 18) Descriptor: 2-oxopentadecyl-CoA, CHLORIDE ION, DIMETHYL SULFOXIDE, ... Authors: Yu, Z, Brannigan, J.A, Rangachari, K, Heal, W.P, Wilkinson, A.J, Holder, A.A, Tate, E.W, Leatherbarrow, R.J. Deposit date: 2015-03-19 Release date: 2016-02-03 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Discovery of Pyridyl-Based Inhibitors of Plasmodium Falciparum N-Myristoyltransferase Medchemcomm, 6, 2015
6QDA	Leishmania major N-myristoyltransferase in complex with quinazoline inhibitor IMP-0000811 Descriptor: 3-[methyl-[2-[methyl-(1-methylpiperidin-4-yl)amino]quinazolin-4-yl]amino]propanenitrile, Glycylpeptide N-tetradecanoyltransferase, MAGNESIUM ION, ... Authors: Brannigan, J.A. Deposit date: 2019-01-01 Release date: 2020-05-06 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Novel Thienopyrimidine Inhibitors of Leishmania N -Myristoyltransferase with On-Target Activity in Intracellular Amastigotes. J.Med.Chem., 63, 2020
6QDG	Leishmania major N-myristoyltransferase in complex with quinazoline inhibitor IMP-0000169 Descriptor: 3-[[6-bromanyl-2-[3-(dimethylamino)propyl-methyl-amino]quinazolin-4-yl]-methyl-amino]propanenitrile, Glycylpeptide N-tetradecanoyltransferase, MAGNESIUM ION, ... Authors: Brannigan, J.A. Deposit date: 2019-01-01 Release date: 2020-05-06 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.98 Å) Cite: Novel Thienopyrimidine Inhibitors of Leishmania N -Myristoyltransferase with On-Target Activity in Intracellular Amastigotes. J.Med.Chem., 63, 2020
4UCN	CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A FRAGMENT Descriptor: 2-PIPERAZIN-1-YL-ANILINE, GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, TETRADECANOYL-COA Authors: Robinson, D.A, Wyatt, P.G. Deposit date: 2014-12-04 Release date: 2015-05-13 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Identification and Structure Solution of Fragment Hits Against Kinetoplastid N-Myristoyltransferase Acta Crystallogr.,Sect.F, 71, 2015
4UCP	CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A FRAGMENT Descriptor: GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, N-methyl-1-[3-(morpholin-4-ylmethyl)phenyl]methanamine, TETRADECANOYL-COA Authors: Robinson, D.A, Wyatt, P.G. Deposit date: 2014-12-04 Release date: 2015-05-13 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Identification and Structure Solution of Fragment Hits Against Kinetoplastid N-Myristoyltransferase Acta Crystallogr.,Sect.F, 71, 2015
6QDD	Leishmania major N-myristoyltransferase in complex with thienopyrimidine inhibitor IMP-0000105 Descriptor: 2-[(2~{S})-1-[2-[methyl-(1-methylpiperidin-4-yl)amino]thieno[3,2-d]pyrimidin-4-yl]-2,3-dihydropyrrol-2-yl]ethanenitrile, DIMETHYL SULFOXIDE, Glycylpeptide N-tetradecanoyltransferase, ... Authors: Brannigan, J.A. Deposit date: 2019-01-01 Release date: 2020-05-06 Last modified: 2020-12-02 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Novel Thienopyrimidine Inhibitors of Leishmania N -Myristoyltransferase with On-Target Activity in Intracellular Amastigotes. J.Med.Chem., 63, 2020
4UWI	Crystal structure of Aspergillus fumigatus N-myristoyl transferase in complex with myristoyl CoA and a pyrazole sulphonamide ligand Descriptor: 2,6-dichloro-4-[3-(4-methylpiperazin-1-yl)propyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide, GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, TETRADECANOYL-COA Authors: Robinson, D.A, Brand, S, Norcross, N.R, Thompson, S, Harrison, J.R, Smith, V.C, Torrie, L.S, McElroy, S.P, Hallyburton, I, Norval, S, Stojanovski, L, Simeons, F.R.C, Frearson, J.A, Brenk, R, Fairlamb, A.H, Ferguson, M.A.J, Wyatt, P.G, Gilbert, I.H, Read, K.D. Deposit date: 2014-08-12 Release date: 2014-12-03 Last modified: 2018-02-14 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Lead optimization of a pyrazole sulfonamide series of Trypanosoma brucei N-myristoyltransferase inhibitors: identification and evaluation of CNS penetrant compounds as potential treatments for stage 2 human African trypanosomiasis. J. Med. Chem., 57, 2014
6QDC	Leishmania major N-myristoyltransferase in complex with thienopyrimidine inhibitor IMP-0000101 Descriptor: 3-[[2-[(1-ethylpiperidin-4-yl)-methyl-amino]thieno[3,2-d]pyrimidin-4-yl]-methyl-amino]propanenitrile, Glycylpeptide N-tetradecanoyltransferase, MAGNESIUM ION, ... Authors: Brannigan, J.A. Deposit date: 2019-01-01 Release date: 2020-05-06 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Novel Thienopyrimidine Inhibitors of Leishmania N -Myristoyltransferase with On-Target Activity in Intracellular Amastigotes. J.Med.Chem., 63, 2020
6QD9	Leishmania major N-myristoyltransferase in complex with thienopyrimidine inhibitor IMP-0000065 Descriptor: 3-[[2-[3-(dimethylamino)propyl-methyl-amino]thieno[3,2-d]pyrimidin-4-yl]-methyl-amino]propanenitrile, Glycylpeptide N-tetradecanoyltransferase, MAGNESIUM ION, ... Authors: Brannigan, J.A. Deposit date: 2019-01-01 Release date: 2020-05-06 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.46 Å) Cite: Novel Thienopyrimidine Inhibitors of Leishmania N -Myristoyltransferase with On-Target Activity in Intracellular Amastigotes. J.Med.Chem., 63, 2020
6QDH	Leishmania major N-myristoyltransferase in complex with quinazoline inhibitor IMP-0000906 Descriptor: 4-[ethyl(methyl)amino]-2-[methyl-(1-methylpiperidin-4-yl)amino]-~{N}-(1,3,5-trimethylpyrazol-4-yl)quinazoline-6-sulfonamide, Glycylpeptide N-tetradecanoyltransferase, MAGNESIUM ION, ... Authors: Brannigan, J.A. Deposit date: 2019-01-01 Release date: 2020-05-06 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Novel Thienopyrimidine Inhibitors of Leishmania N -Myristoyltransferase with On-Target Activity in Intracellular Amastigotes. J.Med.Chem., 63, 2020
6QDF	Leishmania major N-myristoyltransferase in complex with thienopyrimidine inhibitor IMP-0000096 Descriptor: 3-[[6-tert-butyl-2-[methyl-[(3S)-1-methylpyrrolidin-3-yl]amino]thieno[3,2-d]pyrimidin-4-yl]-methyl-amino]propanenitrile, Glycylpeptide N-tetradecanoyltransferase, MAGNESIUM ION, ... Authors: Brannigan, J.A. Deposit date: 2019-01-01 Release date: 2020-05-06 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.49 Å) Cite: Novel Thienopyrimidine Inhibitors of Leishmania N -Myristoyltransferase with On-Target Activity in Intracellular Amastigotes. J.Med.Chem., 63, 2020
6QDE	Leishmania major N-myristoyltransferase in complex with thienopyrimidine inhibitor IMP-0000877 Descriptor: 3-[[6-~{tert}-butyl-2-[3-(dimethylamino)propyl-methyl-amino]thieno[3,2-d]pyrimidin-4-yl]-methyl-amino]propanenitrile, Glycylpeptide N-tetradecanoyltransferase, MAGNESIUM ION, ... Authors: Brannigan, J.A. Deposit date: 2019-01-01 Release date: 2020-05-06 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Novel Thienopyrimidine Inhibitors of Leishmania N -Myristoyltransferase with On-Target Activity in Intracellular Amastigotes. J.Med.Chem., 63, 2020
6QRM	HsNMT1 in complex with both MyrCoA and GNCFSKRRAA substrates Descriptor: Apoptosis-inducing factor 3, CHLORIDE ION, COENZYME A, ... Authors: Dian, C, Riviere, F.B, Asensio, T, Giglione, C, Meinnel, T. Deposit date: 2019-02-19 Release date: 2020-03-18 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.3 Å) Cite: High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation. Nat Commun, 11, 2020
6SK2	HsNMT1 in complex with both MyrCoA and Acetylated-GKSFSKPR peptide reveals N-terminal Lysine Myristoylation Descriptor: Apoptosis-inducing factor 3, COENZYME A, GLYCEROL, ... Authors: Dian, C, Riviere, F.B, Asensio, T, Giglione, C, Meinnel, T. Deposit date: 2019-08-14 Release date: 2020-03-18 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.90000653 Å) Cite: High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation. Nat Commun, 11, 2020
6SKJ	DeltaC2 C-terminal truncation of HsNMT1 in complex with MyrCoA and GNCFSKPR substrates Descriptor: Apoptosis-inducing factor 3, COENZYME A, GLYCEROL, ... Authors: Dian, C, Riviere, F.B, Asensio, T, Giglione, C, Meinnel, T. Deposit date: 2019-08-15 Release date: 2020-03-18 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.8 Å) Cite: High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation. Nat Commun, 11, 2020
6SK8	DeltaC3 C-terminal truncation of HsNMT1 in complex with MyrCoA and GDCFSKPR substrates Descriptor: Apoptosis-inducing factor 3, CHLORIDE ION, GLYCEROL, ... Authors: Dian, C, Riviere, F.B, Asensio, T, Giglione, C, Meinnel, T. Deposit date: 2019-08-14 Release date: 2020-03-18 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.87 Å) Cite: High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation. Nat Commun, 11, 2020
6SJZ	HsNMT1 in complex with both MyrCoA and Acetylated-GNCFSKPR substrates Descriptor: Apoptosis-inducing factor 3, CHLORIDE ION, GLYCEROL, ... Authors: Dian, C, Riviere, F.B, Asensio, T, Giglione, C, Meinnel, T. Deposit date: 2019-08-14 Release date: 2020-03-18 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.995 Å) Cite: High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation. Nat Commun, 11, 2020

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