8B18
 
 | | DtpB-Nb132-AF | | 分子名称: | ALA-PHE, DECANE, DODECANE, ... | | 著者 | Killer, M, Finocchio, G, Lei, J, Jungnickel, K, Kotov, V, Steinke, J, Bartels, K, Strauss, J, Dupeux, F, Humm, A.S, Cornaciu, I, Marquez, J, Pardon, E, Steyeart, J, Loew, C. | | 登録日 | 2022-09-09 | | 公開日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Plasticity of the binding pocket in peptide transporters underpins promiscuous substrate recognition.
Cell Rep, 42, 2023
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8B19
 | | DtpB-Nb132-AFA | | 分子名称: | ALA-PHE-ALA, DECANE, DODECANE, ... | | 著者 | Killer, M, Finocchio, G, Lei, J, Jungnickel, K, Kotov, V, Steinke, J, Bartels, K, Strauss, J, Dupeux, F, Humm, A.S, Cornaciu, I, Marquez, J, Pardon, E, Steyeart, J, Loew, C. | | 登録日 | 2022-09-09 | | 公開日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Plasticity of the binding pocket in peptide transporters underpins promiscuous substrate recognition.
Cell Rep, 42, 2023
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8P6A
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7S8U
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7ZC2
 | | Dipeptide and tripeptide Permease C (DtpC) | | 分子名称: | Amino acid/peptide transporter | | 著者 | Killer, M, Finocchio, G, Pardon, E, Steyaert, J, Loew, C. | | 登録日 | 2022-03-25 | | 公開日 | 2022-07-06 | | 最終更新日 | 2022-08-10 | | 実験手法 | ELECTRON MICROSCOPY (2.72 Å) | | 主引用文献 | Cryo-EM Structure of an Atypical Proton-Coupled Peptide Transporter: Di- and Tripeptide Permease C.
Front Mol Biosci, 9, 2022
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7Q0L
 | | Crystal structure of the peptide transporter YePEPT-K314A at 2.93 A | | 分子名称: | Peptide transporter YePEPT | | 著者 | Jeckelmann, J.M, Stauffer, M, Ilgue, H, Boggavarapu, R, Fotiadis, D. | | 登録日 | 2021-10-15 | | 公開日 | 2022-03-09 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.71 Å) | | 主引用文献 | Peptide transporter structure reveals binding and action mechanism of a potent PEPT1 and PEPT2 inhibitor.
Commun Chem, 5, 2022
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7Q0M
 | | Crystal structure of the peptide transporter YePEPT-K314A in complex with LZNV at 2.66 A | | 分子名称: | (2~{S})-2-[[(2~{S})-2-azanyl-6-[(4-nitrophenyl)methoxycarbonylamino]hexanoyl]amino]-3-methyl-butanoic acid, Peptide transporter YePEPT, UNDECYL-MALTOSIDE | | 著者 | Jeckelmann, J.M, Stauffer, M, Ilgue, H, Fotiadis, D. | | 登録日 | 2021-10-15 | | 公開日 | 2022-03-09 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | | 主引用文献 | Peptide transporter structure reveals binding and action mechanism of a potent PEPT1 and PEPT2 inhibitor.
Commun Chem, 5, 2022
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7PMW
 | | HsPepT1 bound to Ala-Phe in the outward facing occluded conformation | | 分子名称: | ALA-PHE, Solute carrier family 15 member 1 | | 著者 | Killer, M, Wald, J, Pieprzyk, J, Marlovits, T.C, Loew, C. | | 登録日 | 2021-09-03 | | 公開日 | 2021-10-20 | | 最終更新日 | 2021-11-17 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Structural snapshots of human PepT1 and PepT2 reveal mechanistic insights into substrate and drug transport across epithelial membranes.
Sci Adv, 7, 2021
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7PMX
 | | HsPepT1 bound to Ala-Phe in the outward facing open conformation | | 分子名称: | ALA-PHE, Solute carrier family 15 member 1 | | 著者 | Killer, M, Wald, J, Pieprzyk, J, Marlovits, T.C, Loew, C. | | 登録日 | 2021-09-03 | | 公開日 | 2021-10-20 | | 最終更新日 | 2021-11-17 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structural snapshots of human PepT1 and PepT2 reveal mechanistic insights into substrate and drug transport across epithelial membranes.
Sci Adv, 7, 2021
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7PMY
 | | HsPepT2 bound to Ala-Phe in the inward facing partially occluded conformation | | 分子名称: | ALA-PHE, Solute carrier family 15 member 2 | | 著者 | Killer, M, Wald, J, Pieprzyk, J, Marlovits, T.C, Loew, C. | | 登録日 | 2021-09-04 | | 公開日 | 2021-10-20 | | 最終更新日 | 2021-11-17 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structural snapshots of human PepT1 and PepT2 reveal mechanistic insights into substrate and drug transport across epithelial membranes.
Sci Adv, 7, 2021
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7PN1
 | | Apo HsPepT1 in the outward facing open conformation | | 分子名称: | Solute carrier family 15 member 1 | | 著者 | Killer, M, Wald, J, Pieprzyk, J, Marlovits, T.C, Loew, C. | | 登録日 | 2021-09-04 | | 公開日 | 2021-10-20 | | 最終更新日 | 2021-11-17 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Structural snapshots of human PepT1 and PepT2 reveal mechanistic insights into substrate and drug transport across epithelial membranes.
Sci Adv, 7, 2021
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7AC6
 | | Structure of sponge-phase grown PepTst2 collected by rotation serial crystallography on a COC membrane at a synchrotron source | | 分子名称: | (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE, 2-(2-METHOXYETHOXY)ETHANOL, Di-or tripeptide:H+ symporter, ... | | 著者 | Martiel, I, Padeste, C, Karpik, A, Huang, C.Y, Wang, M, Marsh, M. | | 登録日 | 2020-09-10 | | 公開日 | 2021-09-01 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Versatile microporous polymer-based supports for serial macromolecular crystallography.
Acta Crystallogr D Struct Biol, 77, 2021
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7NQK
 | | Cryo-EM structure of the mammalian peptide transporter PepT2 | | 分子名称: | Solute carrier family 15 member 2, nanobody | | 著者 | Parker, J.L, Deme, J.C, Lea, S.M, Newstead, S. | | 登録日 | 2021-03-01 | | 公開日 | 2021-07-07 | | 最終更新日 | 2021-10-13 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Cryo-EM structure of PepT2 reveals structural basis for proton-coupled peptide and prodrug transport in mammals.
Sci Adv, 7, 2021
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6YOF
 | | Structure of PepTSt from COC IMISX setup collected by rotation serial crystallography on crystals prelocated by 2D X-ray phase-contrast imaging | | 分子名称: | (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE, 2-(2-METHOXYETHOXY)ETHANOL, Di-or tripeptide:H+ symporter, ... | | 著者 | Huang, C.-Y, Martiel, I, Villanueva-Perez, P, Panepucci, E, Caffrey, M, Wang, M. | | 登録日 | 2020-04-14 | | 公開日 | 2020-11-04 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Low-dose in situ prelocation of protein microcrystals by 2D X-ray phase-contrast imaging for serial crystallography.
Iucrj, 7, 2020
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6YOG
 | | Structure of PepTSt from COC IMISX setup collected by still serial crystallography on crystals prelocated by 2D X-ray phase-contrast imaging | | 分子名称: | (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE, 2-(2-METHOXYETHOXY)ETHANOL, Di-or tripeptide:H+ symporter, ... | | 著者 | Huang, C.-Y, Martiel, I, Villanueva-Perez, P, Panepucci, E, Caffrey, M, Wang, M. | | 登録日 | 2020-04-14 | | 公開日 | 2020-11-04 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Low-dose in situ prelocation of protein microcrystals by 2D X-ray phase-contrast imaging for serial crystallography.
Iucrj, 7, 2020
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6JI1
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6JKD
 | | Crystal structure of tetrameric PepTSo2 in I4 space group | | 分子名称: | Proton:oligopeptide symporter POT family | | 著者 | Nagamura, R, Fukuda, M, Ishitani, R, Nureki, O. | | 登録日 | 2019-02-28 | | 公開日 | 2019-05-15 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.9 Å) | | 主引用文献 | Structural basis for oligomerization of the prokaryotic peptide transporter PepTSo2.
Acta Crystallogr.,Sect.F, 75, 2019
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6JKC
 | | Crystal structure of tetrameric PepTSo2 in P4212 space group | | 分子名称: | Proton:oligopeptide symporter POT family | | 著者 | Nagamura, R, Fukuda, M, Ishitani, R, Nureki, O. | | 登録日 | 2019-02-28 | | 公開日 | 2019-05-15 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Structural basis for oligomerization of the prokaryotic peptide transporter PepTSo2.
Acta Crystallogr.,Sect.F, 75, 2019
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6GS1
 | | Crystal structure of peptide transporter DtpA-nanobody in MES buffer | | 分子名称: | Dipeptide and tripeptide permease A, Nanobody 00 | | 著者 | Ural-Blimke, Y, Flayhan, A, Loew, C, Quistgaard, E.M. | | 登録日 | 2018-06-13 | | 公開日 | 2019-01-30 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3.29 Å) | | 主引用文献 | Structure of Prototypic Peptide Transporter DtpA from E. coli in Complex with Valganciclovir Provides Insights into Drug Binding of Human PepT1.
J. Am. Chem. Soc., 141, 2019
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6GS4
 | | Crystal structure of peptide transporter DtpA-nanobody in complex with valganciclovir | | 分子名称: | DODECYL-BETA-D-MALTOSIDE, Dipeptide and tripeptide permease A, [(2~{S})-2-[(2-azanyl-6-oxidanylidene-3~{H}-purin-9-yl)methoxy]-3-oxidanyl-propyl] (2~{S})-2-azanyl-3-methyl-butanoate, ... | | 著者 | Ural-Blimke, Y, Flayhan, A, Quistgaard, E.M, Loew, C. | | 登録日 | 2018-06-13 | | 公開日 | 2019-01-30 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.645 Å) | | 主引用文献 | Structure of Prototypic Peptide Transporter DtpA from E. coli in Complex with Valganciclovir Provides Insights into Drug Binding of Human PepT1.
J. Am. Chem. Soc., 141, 2019
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6GS7
 | | Crystal structure of peptide transporter DtpA-nanobody in glycine buffer | | 分子名称: | Dipeptide and tripeptide permease A, nanobody | | 著者 | Ural-Blimke, Y, Flayhan, A, Quistgaard, E.M, Loew, C. | | 登録日 | 2018-06-13 | | 公開日 | 2019-01-30 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Structure of Prototypic Peptide Transporter DtpA from E. coli in Complex with Valganciclovir Provides Insights into Drug Binding of Human PepT1.
J. Am. Chem. Soc., 141, 2019
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6GHJ
 | | PepTSt in complex with tripeptide Phe-Ala-Gln | | 分子名称: | (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE, (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | | 著者 | Martinez Molledo, M, Quistgaard, E.M, Loew, C. | | 登録日 | 2018-05-08 | | 公開日 | 2018-09-19 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | | 主引用文献 | Tripeptide binding in a proton-dependent oligopeptide transporter.
FEBS Lett., 592, 2018
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6FMY
 | | IMISX-EP of S-PepTSt | | 分子名称: | (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE, 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, Di-or tripeptide:H+ symporter, ... | | 著者 | Huang, C.-Y, Olieric, V, Howe, N, Warshamanage, R, Weinert, T, Panepucci, E, Vogeley, L, Basu, S, Diederichs, K, Caffrey, M, Wang, M. | | 登録日 | 2018-02-02 | | 公開日 | 2018-09-05 | | 最終更新日 | 2018-10-10 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | In situ serial crystallography for rapid de novo membrane protein structure determination.
Commun Biol, 1, 2018
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6FMR
 | | IMISX-EP of Se-PepTSt | | 分子名称: | (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE, Di-or tripeptide:H+ symporter, PHOSPHATE ION | | 著者 | Huang, C.-Y, Olieric, V, Howe, N, Warshamanage, R, Weinert, T, Panepucci, E, Vogeley, L, Basu, S, Diederichs, K, Caffrey, M, Wang, M. | | 登録日 | 2018-02-02 | | 公開日 | 2018-08-29 | | 最終更新日 | 2018-10-10 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | In situ serial crystallography for rapid de novo membrane protein structure determination.
Commun Biol, 1, 2018
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5OXN
 | | PepTSt in complex with dipeptide Phe-Ala | | 分子名称: | (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE, (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE, ALANINE, ... | | 著者 | Martinez Molledo, M, Quistgaard, E.M, Loew, C. | | 登録日 | 2017-09-07 | | 公開日 | 2018-02-21 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.196 Å) | | 主引用文献 | Multispecific Substrate Recognition in a Proton-Dependent Oligopeptide Transporter.
Structure, 26, 2018
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