8CH7
 
 | | RDC-refined Interleukin-4 (wild type) pH 5.6 | | 分子名称: | Interleukin-4 | | 著者 | Vaz, D.C, Rodrigues, J.R, Loureiro-Ferreira, N, Mueller, T, Sebald, W, Redfield, C, Brito, R.M.M. | | 登録日 | 2023-02-07 | | 公開日 | 2023-10-18 | | 最終更新日 | 2024-01-17 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Lessons on protein structure from interleukin-4: All disulfides are not created equal.
Proteins, 92, 2024
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8CGF
 | | Interleukin-4 (wild type) pH 2.4 | | 分子名称: | Interleukin-4 | | 著者 | Vaz, D.C, Rodrigues, J.R, Loureiro-Ferreira, N, Mueller, T, Sebald, W, Redfield, C, Brito, R.M.M. | | 登録日 | 2023-02-04 | | 公開日 | 2023-10-18 | | 最終更新日 | 2024-01-17 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Lessons on protein structure from interleukin-4: All disulfides are not created equal.
Proteins, 92, 2024
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8A4F
 | | Human Interleukin-4 mutant - C3T-IL4 | | 分子名称: | Interleukin-4 | | 著者 | Vaz, D.C, Rodrigues, J.R, Mueller, T.D, Sebald, W, Redfield, C, Brito, R.M.M. | | 登録日 | 2022-06-11 | | 公開日 | 2023-10-18 | | 最終更新日 | 2024-01-17 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Lessons on protein structure from interleukin-4: All disulfides are not created equal.
Proteins, 92, 2024
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6OEL
 | | Engineered Fab bound to IL-4 receptor | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common subunit gamma, Interleukin-4 receptor subunit alpha, ... | | 著者 | Jude, K.M, Moraga, I, Spangler, J.B, Garcia, K.C. | | 登録日 | 2019-03-27 | | 公開日 | 2019-08-07 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | A strategy for the selection of monovalent antibodies that span protein dimer interfaces.
J.Biol.Chem., 294, 2019
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5FHX
 | | CRYSTAL STRUCTURE OF CODV IN COMPLEX WITH IL4 AT 2.55 Ang. RESOLUTION. | | 分子名称: | Antibody fragment light chain, Interleukin-4, PHOSPHATE ION, ... | | 著者 | Vallee, F, Dupuy, A, Rak, A. | | 登録日 | 2015-12-22 | | 公開日 | 2016-03-30 | | 最終更新日 | 2018-10-24 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | CODV-Ig, a universal bispecific tetravalent and multifunctional immunoglobulin format for medical applications.
Mabs, 8, 2016
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4YDY
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3QB7
 | | Interleukin-4 mutant RGA bound to cytokine receptor common gamma | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common subunit gamma, ... | | 著者 | Bates, D.L, Junttila, I.S, Creusot, R.J, Moraga, I, Lupardus, P, Fathman, C.G, Paul, W.E, Garcia, K.C. | | 登録日 | 2011-01-12 | | 公開日 | 2012-04-25 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (3.245 Å) | | 主引用文献 | Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines.
Nat.Chem.Biol., 8, 2012
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3BPN
 | | Crystal structure of the IL4-IL4R-IL13Ra ternary complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-13 receptor alpha-1 chain, Interleukin-4, ... | | 著者 | Garcia, K.C. | | 登録日 | 2007-12-18 | | 公開日 | 2008-02-05 | | 最終更新日 | 2021-10-20 | | 実験手法 | X-RAY DIFFRACTION (3.02 Å) | | 主引用文献 | Molecular and Structural Basis of Cytokine Receptor Pleiotropy in the Interleukin-4/13 System.
Cell(Cambridge,Mass.), 132, 2008
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3BPL
 | | Crystal structure of the IL4-IL4R-Common Gamma ternary complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Garcia, K.C. | | 登録日 | 2007-12-18 | | 公開日 | 2008-02-05 | | 最終更新日 | 2021-10-20 | | 実験手法 | X-RAY DIFFRACTION (2.93 Å) | | 主引用文献 | Molecular and Structural Basis of Cytokine Receptor Pleiotropy in the Interleukin-4/13 System.
Cell(Cambridge,Mass.), 132, 2008
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2INT
 | | CRYSTAL STRUCTURE OF RECOMBINANT HUMAN INTERLEUKIN-4 | | 分子名称: | INTERLEUKIN-4 | | 著者 | Walter, M.R, Cook, W.J, Zhao, B.G, Cameron Junior, R, Ealick, S.E, Walter Junior, R.L, Reichert, P, Nagabhushan, T.L, Trotta, P.P, Bugg, C.E. | | 登録日 | 1993-07-22 | | 公開日 | 1994-01-31 | | 最終更新日 | 2019-08-14 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Crystal structure of recombinant human interleukin-4.
J.Biol.Chem., 267, 1992
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2D48
 | | Crystal structure of the Interleukin-4 variant T13D | | 分子名称: | Interleukin-4, SULFATE ION | | 著者 | Kraich, M, Klein, M, Patino, E, Harrer, H, Sebald, W, Mueller, T.D. | | 登録日 | 2005-10-11 | | 公開日 | 2006-05-30 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor
Bmc Biol., 4, 2006
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2CYK
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2B91
 | | Crystal structure of the interleukin-4 variant F82DR85A | | 分子名称: | Interleukin-4, SULFATE ION | | 著者 | Kraich, M, Klein, M, Patino, E, Harrer, H, Sebald, W, Mueller, T.D. | | 登録日 | 2005-10-10 | | 公開日 | 2006-05-30 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor
Bmc Biol., 4, 2006
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2B90
 | | Crystal structure of the interleukin-4 variant T13DR85A | | 分子名称: | Interleukin-4, SULFATE ION | | 著者 | Kraich, M, Klein, M, Patino, E, Harrer, H, Sebald, W, Mueller, T.D. | | 登録日 | 2005-10-10 | | 公開日 | 2006-05-30 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor
Bmc Biol., 4, 2006
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2B8Z
 | | Crystal structure of the interleukin-4 variant R85A | | 分子名称: | Interleukin-4, SULFATE ION | | 著者 | Kraich, M, Klein, M, Patino, E, Harrer, H, Sebald, W, Mueller, T.D. | | 登録日 | 2005-10-10 | | 公開日 | 2006-05-30 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor
Bmc Biol., 4, 2006
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2B8Y
 | | Crystal structure of the interleukin-4 variant T13DF82D | | 分子名称: | Interleukin-4, SULFATE ION | | 著者 | Kraich, M, Klein, M, Patino, E, Harrer, H, Sebald, W, Mueller, T.D. | | 登録日 | 2005-10-10 | | 公開日 | 2006-05-30 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor
Bmc Biol., 4, 2006
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2B8X
 | | Crystal structure of the interleukin-4 variant F82D | | 分子名称: | Interleukin-4, SULFATE ION | | 著者 | Kraich, M, Klein, M, Patino, E, Harrer, H, Sebald, W, Mueller, T.D. | | 登録日 | 2005-10-10 | | 公開日 | 2006-05-30 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor
Bmc Biol., 4, 2006
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2B8U
 | | Crystal structure of wildtype human Interleukin-4 | | 分子名称: | Interleukin-4, SULFATE ION | | 著者 | Kraich, M, Klein, M, Patino, E, Harrer, H, Sebald, W, Mueller, T.D. | | 登録日 | 2005-10-10 | | 公開日 | 2006-05-30 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor
Bmc Biol., 4, 2006
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1RCB
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1ITM
 | | ANALYSIS OF THE SOLUTION STRUCTURE OF HUMAN INTERLEUKIN 4 DETERMINED BY HETERONUCLEAR THREE-DIMENSIONAL NUCLEAR MAGNETIC RESONANCE TECHNIQUES | | 分子名称: | INTERLEUKIN-4 | | 著者 | Redfield, C, Smith, L.J, Boyd, J, Lawrence, G.M.P, Edwards, R.G, Gershater, C.J, Smith, R.A.G, Dobson, C.M. | | 登録日 | 1994-02-28 | | 公開日 | 1994-05-31 | | 最終更新日 | 2022-02-23 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Analysis of the solution structure of human interleukin-4 determined by heteronuclear three-dimensional nuclear magnetic resonance techniques.
J.Mol.Biol., 238, 1994
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1ITL
 | | HUMAN INTERLEUKIN 4: THE SOLUTION STRUCTURE OF A FOUR-HELIX-BUNDLE PROTEIN | | 分子名称: | INTERLEUKIN-4 | | 著者 | Smith, L.J, Redfield, C, Boyd, J, Lawrence, G.M.P, Edwards, R.G, Smith, R.A.G, Dobson, C.M. | | 登録日 | 1992-02-08 | | 公開日 | 1993-04-15 | | 最終更新日 | 2022-02-23 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Human interleukin 4. The solution structure of a four-helix bundle protein.
J.Mol.Biol., 224, 1992
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1ITI
 | | THE HIGH RESOLUTION THREE-DIMENSIONAL SOLUTION STRUCTURE OF HUMAN INTERLEUKIN-4 DETERMINED BY MULTI-DIMENSIONAL HETERONUCLEAR MAGNETIC RESONANCE SPECTROSCOPY | | 分子名称: | INTERLEUKIN-4 | | 著者 | Clore, G.M, Powers, B, Garrett, D.S, Gronenborn, A.M. | | 登録日 | 1993-04-12 | | 公開日 | 1993-07-15 | | 最終更新日 | 2022-02-23 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The high-resolution, three-dimensional solution structure of human interleukin-4 determined by multidimensional heteronuclear magnetic resonance spectroscopy.
Biochemistry, 32, 1993
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1IAR
 | | INTERLEUKIN-4 / RECEPTOR ALPHA CHAIN COMPLEX | | 分子名称: | PROTEIN (INTERLEUKIN-4 RECEPTOR ALPHA CHAIN), PROTEIN (INTERLEUKIN-4) | | 著者 | Hage, T, Sebald, W, Reinemer, P. | | 登録日 | 1999-02-25 | | 公開日 | 2000-03-03 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface.
Cell(Cambridge,Mass.), 97, 1999
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1HZI
 | | INTERLEUKIN-4 MUTANT E9A | | 分子名称: | INTERLEUKIN-4, SULFATE ION | | 著者 | Hulsmeyer, M, Scheufler, C, Dreyer, M.K. | | 登録日 | 2001-01-25 | | 公開日 | 2001-08-29 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Structure of interleukin 4 mutant E9A suggests polar steering in receptor-complex formation.
Acta Crystallogr.,Sect.D, 57, 2001
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1HIK
 | | INTERLEUKIN-4 (WILD-TYPE) | | 分子名称: | INTERLEUKIN-4 | | 著者 | Mueller, T, Buehner, M. | | 登録日 | 1995-06-01 | | 公開日 | 1996-01-29 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Human interleukin-4 and variant R88Q: phasing X-ray diffraction data by molecular replacement using X-ray and nuclear magnetic resonance models.
J.Mol.Biol., 247, 1995
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