2FED
| Structure of the E203Q mutant of the Cl-/H+ exchanger CLC-ec1 from E.Coli | Descriptor: | Fab fragment, heavy chain, light chain, ... | Authors: | Accardi, A, Walden, M.P, Nguitragool, W, Jayaram, H, Williams, C, Miller, C. | Deposit date: | 2005-12-15 | Release date: | 2006-01-03 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.317 Å) | Cite: | Separate ion pathways in a Cl-/H+ exchanger J.Gen.Physiol., 126, 2005
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8GA1
| CLC-ec1 R230C/L249C/C85A at pH 4.5 100mM Cl Swap | Descriptor: | CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA | Authors: | Fortea, E, Lee, S, Argyos, Y, Chadda, R, Ciftci, D, Huysmans, G, Robertson, J.L, Boudker, O, Accardi, A. | Deposit date: | 2023-02-22 | Release date: | 2024-02-07 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structural basis of pH-dependent activation in a CLC transporter. Nat.Struct.Mol.Biol., 31, 2024
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8GA3
| CLC-ec1 R230C/L249C/C85A at pH 4.5 100mM Cl Turn | Descriptor: | CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA | Authors: | Fortea, E, Lee, S, Argyos, Y, Chadda, R, Ciftci, D, Huysmans, G, Robertson, J.L, Boudker, O, Accardi, A. | Deposit date: | 2023-02-22 | Release date: | 2024-02-07 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis of pH-dependent activation in a CLC transporter. Nat.Struct.Mol.Biol., 31, 2024
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8GAH
| CLC-ec1 L25C/A450C/C85A at pH 4.5 100mM Cl Twist | Descriptor: | CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA | Authors: | Fortea, E, Lee, S, Argyos, Y, Chadda, R, Ciftci, D, Huysmans, G, Robertson, J.L, Boudker, O, Accardi, A. | Deposit date: | 2023-02-22 | Release date: | 2024-02-07 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural basis of pH-dependent activation in a CLC transporter. Nat.Struct.Mol.Biol., 31, 2024
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8GA5
| CLC-ec1 L25C/A450C/C85A at pH 4.5 100mM Cl Intermediate | Descriptor: | CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA | Authors: | Fortea, E, Lee, S, Argyos, Y, Chadda, R, Ciftci, D, Huysmans, G, Robertson, J.L, Boudker, O, Accardi, A. | Deposit date: | 2023-02-22 | Release date: | 2024-02-07 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structural basis of pH-dependent activation in a CLC transporter. Nat.Struct.Mol.Biol., 31, 2024
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8GA0
| CLC-ec1 E202Y at pH 4.5 100mM Cl Turn | Descriptor: | H(+)/Cl(-) exchange transporter ClcA | Authors: | Fortea, E, Lee, S, Argyos, Y, Chadda, R, Ciftci, D, Huysmans, G, Robertson, J.L, Boudker, O, Accardi, A. | Deposit date: | 2023-02-22 | Release date: | 2024-02-07 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural basis of pH-dependent activation in a CLC transporter. Nat.Struct.Mol.Biol., 31, 2024
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8GQU
| AK-42 inhibitor binding human ClC-2 TMD | Descriptor: | 2-[[2,6-bis(chloranyl)-3-phenylmethoxy-phenyl]amino]pyridine-3-carboxylic acid, Chloride channel protein 2 | Authors: | Wang, L. | Deposit date: | 2022-08-30 | Release date: | 2023-07-05 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42. Nat Commun, 14, 2023
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4KKL
| Structure of the E148A mutant of CLC-ec1 delta NC construct in 100mM fluoride | Descriptor: | FLUORIDE ION, Fab, heavy chain, ... | Authors: | Stockbridge, R.B, Lim, H.-H, Miller, C. | Deposit date: | 2013-05-06 | Release date: | 2013-08-21 | Last modified: | 2013-12-04 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Fluoride-dependent interruption of the transport cycle of a CLC Cl(-)/H(+) antiporter. Nat.Chem.Biol., 9, 2013
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4KJQ
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4KK9
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4KJP
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4KK6
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4KJW
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4KKA
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4KKC
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4LOU
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3EJZ
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2HT3
| Structure of the Escherichia coli ClC chloride channel Y445L mutant and Fab complex | Descriptor: | BROMIDE ION, Fab fragment, Heavy chain, ... | Authors: | Accardi, A, Lobet, S, Williams, C, Miller, C, Dutzler, R. | Deposit date: | 2006-07-25 | Release date: | 2006-09-19 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Synergism between halide binding and proton transport in a CLC-type exchanger J.Mol.Biol., 362, 2006
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2HT4
| Structure of the Escherichia coli ClC chloride channel Y445W mutant and Fab complex | Descriptor: | BROMIDE ION, Fab fragment, Heavy chain, ... | Authors: | Accardi, A, Lobet, S, Williams, C, Miller, C, Dutzler, R. | Deposit date: | 2006-07-25 | Release date: | 2006-09-19 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Synergism Between Halide Binding and Proton Transport in a CLC-type Exchanger. J.Mol.Biol., 362, 2006
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2HTL
| Structure of the Escherichia coli ClC chloride channel Y445F mutant and Fab complex | Descriptor: | BROMIDE ION, Fab fragment, Heavy chain, ... | Authors: | Accardi, A, Lobet, S, Williams, C, Miller, C, Dutzler, R. | Deposit date: | 2006-07-26 | Release date: | 2006-09-19 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Synergism Between Halide Binding and Proton Transport in a CLC-type Exchanger. J.Mol.Biol., 362, 2006
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2HTK
| Structure of the Escherichia coli ClC chloride channel Y445A mutant and Fab complex | Descriptor: | BROMIDE ION, Fab fragment, Heavy chain, ... | Authors: | Accardi, A, Lobet, S, Williams, C, Miller, C, Dutzler, R. | Deposit date: | 2006-07-26 | Release date: | 2006-09-19 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.41 Å) | Cite: | Synergism between halide binding and proton transport in a CLC-type exchanger J.Mol.Biol., 362, 2006
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1OTS
| Structure of the Escherichia coli ClC Chloride channel and Fab Complex | Descriptor: | CHLORIDE ION, Fab fragment (heavy chain), Fab fragment (light chain), ... | Authors: | Dutzler, R, Campbell, E.B, MacKinnon, R. | Deposit date: | 2003-03-22 | Release date: | 2003-04-15 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Gating the Selectivity Filter in ClC Chloride Channels Science, 300, 2003
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1OTU
| Structure of the Escherichia coli ClC Chloride channel E148Q mutant and Fab Complex | Descriptor: | CHLORIDE ION, Fab fragment (Heavy chain), Fab fragment (Light chain), ... | Authors: | Dutzler, R, Campbell, E.B, MacKinnon, R. | Deposit date: | 2003-03-23 | Release date: | 2003-04-15 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Gating the Selectivity Filter in ClC Chloride Channels Science, 300, 2003
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1OTT
| Structure of the Escherichia coli ClC Chloride channel E148A mutant and Fab Complex | Descriptor: | CHLORIDE ION, Fab fragment (Heavy chain), Fab fragment (Light chain), ... | Authors: | Dutzler, R, Campbell, E.B, MacKinnon, R. | Deposit date: | 2003-03-23 | Release date: | 2003-04-15 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Gating the Selectivity Filter in ClC Chloride Channels Science, 300, 2003
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2EXY
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