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1H1C	Histidinol-phosphate aminotransferase (HisC) from Thermotoga maritima Descriptor: HISTIDINOL-PHOSPHATE AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE Authors: Vega, M.C, Fernandez, F.J, Wilmanns, M. Deposit date: 2002-07-08 Release date: 2004-03-19 Last modified: 2019-07-24 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Structural Studies of the Catalytic Reaction Pathway of a Hyperthermophilic Histidinol-Phosphate Aminotransferase J.Biol.Chem., 279, 2004
4EMY	Crystal structure of aminotransferase from anaerococcus prevotii dsm 20548. Descriptor: Aminotransferase class I and II, PYRIDOXAL-5'-PHOSPHATE Authors: Chang, C, Tesar, C, Bearden, J, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) Deposit date: 2012-04-12 Release date: 2012-05-09 Method: X-RAY DIFFRACTION (2.86 Å) Cite: Crystal structure of aminotransferase from anaerococcus prevotii dsm 20548. TO BE PUBLISHED
4EFF	Crystal structure of aromatic-amino-acid aminotransferase from Burkholderia pseudomallei Descriptor: Aromatic-amino-acid aminotransferase, GLYCEROL Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2012-03-29 Release date: 2012-04-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Crystal structure of aromatic-amino-acid aminotransferase from Burkholderia pseudomallei To be Published
4EU1	Structure of a mitochondrial aspartate aminotransferase from Trypanosoma brucei Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Mitochondrial aspartate aminotransferase Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2012-04-25 Release date: 2012-05-16 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structures of aspartate aminotransferases from Trypanosoma brucei, Leishmania major and Giardia lamblia. Acta Crystallogr F Struct Biol Commun, 71, 2015
1IAY	CRYSTAL STRUCTURE OF ACC SYNTHASE COMPLEXED WITH COFACTOR PLP AND INHIBITOR AVG Descriptor: 1-AMINOCYCLOPROPANE-1-CARBOXYLATE SYNTHASE 2, 2-AMINO-4-(2-AMINO-ETHOXY)-BUTYRIC ACID, PYRIDOXAL-5'-PHOSPHATE Authors: Huai, Q, Xia, Y, Chen, Y, Callahan, B, Li, N, Ke, H. Deposit date: 2001-03-24 Release date: 2001-04-04 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Crystal structures of 1-aminocyclopropane-1-carboxylate (ACC) synthase in complex with aminoethoxyvinylglycine and pyridoxal-5'-phosphate provide new insight into catalytic mechanisms J.Biol.Chem., 276, 2001
4F5J	Rational Design and Directed Evolution for Conversion of Substrate Specificity from E.coli Aspartate Aminotransferase to Tyrosine Aminotransferase: Mutant P5. Descriptor: Aspartate aminotransferase Authors: Addington, T.A, Fisher, A.J, Toney, M.D. Deposit date: 2012-05-13 Release date: 2013-02-13 Last modified: 2013-04-24 Method: X-RAY DIFFRACTION (1.954 Å) Cite: Janus: prediction and ranking of mutations required for functional interconversion of enzymes. J.Mol.Biol., 425, 2013
4F5F	Structure of Aspartate Aminotransferase Conversion to Tyrosine Aminotransferase: Chimera P1. Descriptor: Aspartate aminotransferase Authors: Addington, T.A, Fisher, A.J, Toney, M.D. Deposit date: 2012-05-13 Release date: 2013-02-13 Last modified: 2013-04-24 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Janus: prediction and ranking of mutations required for functional interconversion of enzymes. J.Mol.Biol., 425, 2013
4F5M	Wild-Type E. coli Aspartate Aminotransferase: A Template For The Interconversion of Substrate Specificity and Activity To Tyrosine Aminotransferase By The JANUS Algorithm. Descriptor: 1,2-ETHANEDIOL, Aspartate aminotransferase Authors: Addington, T.A, Fisher, A.J, Toney, M.D. Deposit date: 2012-05-13 Release date: 2013-02-13 Last modified: 2013-04-24 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Janus: prediction and ranking of mutations required for functional interconversion of enzymes. J.Mol.Biol., 425, 2013
4F5I	Substrate Specificity Conversion of E. coli Pyridoxal-5'-Phosphate Dependent Aspartate Aminotransferase to Tyrosine Aminotransferase: Chimera P4. Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Aspartate aminotransferase Authors: Addington, T.A, Fisher, A.J, Toney, M.D. Deposit date: 2012-05-13 Release date: 2013-02-13 Last modified: 2013-04-24 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Janus: prediction and ranking of mutations required for functional interconversion of enzymes. J.Mol.Biol., 425, 2013
4F5H	Intercoversion of Substrate Specificity: E. coli Aspatate Aminotransferase to Tyrosine Aminotransferase: Chimera P3. Descriptor: Aspartate aminotransferase Authors: Addington, T.A, Fisher, A.J, Toney, M.D. Deposit date: 2012-05-13 Release date: 2013-02-13 Last modified: 2013-04-24 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Janus: prediction and ranking of mutations required for functional interconversion of enzymes. J.Mol.Biol., 425, 2013
4F5L	A Theoretical Optimized Mutant for the Conversion of Substrate Specificity and Activity of Aspartate Aminotransferase to Tyrosine Aminotransferase: Chimera P7. Descriptor: 1,2-ETHANEDIOL, Aspartate aminotransferase Authors: Addington, T.A, Fisher, A.J, Toney, M.D. Deposit date: 2012-05-13 Release date: 2013-05-15 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Janus: an algorithm for ranking functional importance of residues from protein sequence alignments. To be Published
1IAX	CRYSTAL STRUCTURE OF ACC SYNTHASE COMPLEXED WITH PLP Descriptor: 1-AMINOCYCLOPROPANE-1-CARBOXYLATE SYNTHASE 2, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION Authors: Huai, Q, Xia, Y, Chen, Y, Callahan, B, Li, N, Ke, H. Deposit date: 2001-03-24 Release date: 2001-04-04 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Crystal structures of 1-aminocyclopropane-1-carboxylate (ACC) synthase in complex with aminoethoxyvinylglycine and pyridoxal-5'-phosphate provide new insight into catalytic mechanisms J.Biol.Chem., 276, 2001
4F4E	Crystal structure of Aromatic-amino-acid aminotransferase from Burkholderia pseudomallei covalently bound to pyridoxal phosphate Descriptor: 1,2-ETHANEDIOL, Aromatic-amino-acid aminotransferase Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2012-05-10 Release date: 2012-05-23 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structure of Aromatic-amino-acid aminotransferase from Burkholderia pseudomallei covalently bound to pyridoxal phosphate To be Published
4F5K	Substrate Specificity Conversion of Aspartate Aminotransferase to Tyrosine Aminotransferase By The JANUS Algorithm: Chimera P6. Descriptor: Aspartate aminotransferase Authors: Addington, T.A, Fisher, A.J, Toney, M.D. Deposit date: 2012-05-13 Release date: 2013-02-13 Last modified: 2013-04-24 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Janus: prediction and ranking of mutations required for functional interconversion of enzymes. J.Mol.Biol., 425, 2013
4F5G	Rational Design and Directed Evolution of E. coli Apartate Aminotransferase to Tyrosine Aminotransferase: Mutant P2. Descriptor: Aspartate aminotransferase Authors: Addington, T.A, Fisher, A.J, Toney, M.D. Deposit date: 2012-05-13 Release date: 2013-02-13 Last modified: 2013-04-24 Method: X-RAY DIFFRACTION (1.67 Å) Cite: Janus: prediction and ranking of mutations required for functional interconversion of enzymes. J.Mol.Biol., 425, 2013
1J32	Aspartate Aminotransferase from Phormidium lapideum Descriptor: PYRIDOXAL-5'-PHOSPHATE, aspartate aminotransferase Authors: Kim, H, Sawa, Y, Hamada, K. Deposit date: 2003-01-17 Release date: 2003-02-04 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural studies of aspartate aminotransferase from Phormidium lapideum To be Published
1IX6	Aspartate Aminotransferase Active Site Mutant V39F Descriptor: Aspartate Aminotransferase, PYRIDOXAL-5'-PHOSPHATE Authors: Hayashi, H, Mizuguchi, H, Miyahara, I, Nakajima, Y, Hirotsu, K, Kagamiyama, H. Deposit date: 2002-06-14 Release date: 2002-07-03 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Conformational change in aspartate aminotransferase on substrate binding induces strain in the catalytic group and enhances catalysis J.BIOL.CHEM., 278, 2003
1IJI	Crystal Structure of L-Histidinol Phosphate Aminotransferase with PLP Descriptor: Histidinol Phosphate Aminotransferase, PYRIDOXAL-5'-PHOSPHATE Authors: Sivaraman, J, Li, Y, Larocque, R, Schrag, J.D, Cygler, M, Matte, A. Deposit date: 2001-04-26 Release date: 2001-08-29 Last modified: 2017-10-04 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal structure of histidinol phosphate aminotransferase (HisC) from Escherichia coli, and its covalent complex with pyridoxal-5'-phosphate and l-histidinol phosphate. J.Mol.Biol., 311, 2001
4FL0	Crystal structure of ALD1 from Arabidopsis thaliana Descriptor: Aminotransferase ALD1, PYRIDOXAL-5'-PHOSPHATE Authors: Sobolev, V, Edelman, M, Dym, O, Unger, T, Albeck, S, Kirma, M, Galili, G, Israel Structural Proteomics Center (ISPC) Deposit date: 2012-06-14 Release date: 2013-02-20 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structure of ALD1, a plant-specific homologue of the universal diaminopimelate aminotransferase enzyme of lysine biosynthesis. Acta Crystallogr.,Sect.F, 69, 2013
1IVR	STRUCTURE OF ASPARTATE AMINOTRANSFERASE Descriptor: ASPARTATE AMINOTRANSFERASE, N-PYRIDOXYL-2,3-DIHYDROXYASPARTIC ACID-5-MONOPHOSPHATE Authors: Graf Von Stosch, A. Deposit date: 1996-10-11 Release date: 1997-07-23 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Aspartate aminotransferase complexed with erythro-beta-hydroxyaspartate: crystallographic and spectroscopic identification of the carbinolamine intermediate. Biochemistry, 35, 1996
1IX8	Aspartate Aminotransferase Active Site Mutant V39F/N194A Descriptor: Aspartate Aminotransferase, PYRIDOXAL-5'-PHOSPHATE Authors: Hayashi, H, Mizuguchi, H, Miyahara, I, Nakajima, Y, Hirotsu, K, Kagamiyama, H. Deposit date: 2002-06-14 Release date: 2002-07-03 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Conformational change in aspartate aminotransferase on substrate binding induces strain in the catalytic group and enhances catalysis J.BIOL.CHEM., 278, 2003
1IX7	Aspartate Aminotransferase Active Site Mutant V39F maleate complex Descriptor: Aspartate Aminotransferase, MALEIC ACID, PYRIDOXAL-5'-PHOSPHATE Authors: Hayashi, H, Mizuguchi, H, Miyahara, I, Nakajima, Y, Hirotsu, K, Kagamiyama, H. Deposit date: 2002-06-14 Release date: 2002-07-03 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Conformational change in aspartate aminotransferase on substrate binding induces strain in the catalytic group and enhances catalysis J.BIOL.CHEM., 278, 2003
4GEB	Kynurenine Aminotransferase II Inhibitors Descriptor: (5-hydroxy-4-{[(7-hydroxy-6-oxo-2-phenyl-6,7-dihydro-2H-pyrazolo[3,4-b]pyridin-5-yl)amino]methyl}-6-methylpyridin-3-yl)methyl dihydrogen phosphate, Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial, ... Authors: Pandit, J. Deposit date: 2012-08-01 Release date: 2013-03-20 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.15 Å) Cite: PF-04859989 as a template for structure-based drug design: identification of new pyrazole series of irreversible KAT II inhibitors with improved lipophilic efficiency. Bioorg.Med.Chem.Lett., 23, 2013
4GE7	Kynurenine Aminotransferase II Inhibitors Descriptor: (5-hydroxy-4-{[(1-hydroxy-2-oxo-6-phenoxy-1,2-dihydroquinolin-3-yl)amino]methyl}-6-methylpyridin-3-yl)methyl dihydrogen phosphate, Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Authors: Pandit, J. Deposit date: 2012-08-01 Release date: 2012-11-07 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structure-Based Design of Irreversible Human KAT II Inhibitors: Discovery of New Potency-Enhancing Interactions. ACS Med Chem Lett, 4, 2013
4GE4	Kynurenine Aminotransferase II Inhibitors Descriptor: (5-hydroxy-4-{[(1-hydroxy-7-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)amino]methyl}-6-methylpyridin-3-yl)methyl dihydrogen phosphate, Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Authors: Pandit, J. Deposit date: 2012-08-01 Release date: 2012-11-07 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.41 Å) Cite: Structure-Based Design of Irreversible Human KAT II Inhibitors: Discovery of New Potency-Enhancing Interactions. ACS Med Chem Lett, 4, 2013

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