1AFW
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6PCD
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1QFL
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3GOA
| Crystal structure of the Salmonella typhimurium FadA 3-ketoacyl-CoA thiolase | Descriptor: | 3-ketoacyl-CoA thiolase, CALCIUM ION, CHLORIDE ION, ... | Authors: | Anderson, S.M, Skarina, T, Onopriyenko, O, Wawrzak, Z, Papazisi, L, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2009-03-18 | Release date: | 2009-03-31 | Last modified: | 2017-11-01 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: |
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5MG5
| A multi-component acyltransferase PhlABC from Pseudomonas protegens soaked with the monoacetylphloroglucinol (MAPG) | Descriptor: | 2,4-diacetylphloroglucinol biosynthesis protein, 2,4-diacetylphloroglucinol biosynthesis protein PhlC, Hydroxymethylglutaryl-CoA synthase, ... | Authors: | Pavkov-Keller, T, Schmidt, N.G, Kroutil, W, Gruber, K. | Deposit date: | 2016-11-20 | Release date: | 2017-12-20 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.44 Å) | Cite: | Structure and Catalytic Mechanism of a Bacterial Friedel-Crafts Acylase. Chembiochem, 20, 2019
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7FEA
| PY14 in complex with Col-D | Descriptor: | (6~{R},7~{R},9~{E})-6,7-bis(oxidanyl)hexadeca-9,15-dien-11,13-diynoic acid, Acetyl-CoA C-acyltransferase | Authors: | Lin, C.C, Ko, T.P, Huang, K.F, Yang, Y.L. | Deposit date: | 2021-07-19 | Release date: | 2022-07-27 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Integrated omics approach to unveil antifungal bacterial polyynes as acetyl-CoA acetyltransferase inhibitors. Commun Biol, 5, 2022
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6OK1
| Ltp2-ChsH2(DUF35) aldolase | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, ChsH2(DUF35), ... | Authors: | Kimber, M.S, Mallette, E, Aggett, R, Seah, S.Y.K. | Deposit date: | 2019-04-12 | Release date: | 2019-06-26 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The steroid side-chain-cleaving aldolase Ltp2-ChsH2DUF35is a thiolase superfamily member with a radically repurposed active site. J.Biol.Chem., 294, 2019
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5ONC
| Catabolism of the Cholesterol Side Chain in Mycobacterium tuberculosis is Controlled by a Redox-Sensitive Thiol Switch | Descriptor: | CHLORIDE ION, Steroid 3-ketoacyl-CoA thiolase | Authors: | Schaefer, C, Kuper, J, Sampson, N.S, Kisker, C. | Deposit date: | 2017-08-03 | Release date: | 2017-08-23 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.19 Å) | Cite: | Catabolism of the Cholesterol Side Chain in Mycobacterium tuberculosis Is Controlled by a Redox-Sensitive Thiol Switch. ACS Infect Dis, 3, 2017
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1ULQ
| Crystal structure of tt0182 from Thermus thermophilus HB8 | Descriptor: | putative acetyl-CoA acetyltransferase | Authors: | Ago, H, Hamada, K, Ida, K, Kanda, H, Sugahara, M, Yamamoto, M, Kuroishi, C, Kuramitsu, S, Yokoyama, S, Miyano, M, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2003-09-16 | Release date: | 2004-11-02 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure of tt0182 from Thermus thermophilus HB8 To be Published
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1M3Z
| Biosynthetic thiolase, C89A mutant, complexed with acetyl coenzyme A | Descriptor: | ACETYL COENZYME *A, Acetyl-CoA acetyltransferase, SULFATE ION | Authors: | Kursula, P, Ojala, J, Lambeir, A.-M, Wierenga, R.K. | Deposit date: | 2002-07-03 | Release date: | 2002-11-29 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | The catalytic cycle of biosynthetic thiolase: A conformational
journey of an acetyl group through four binding modes and two oxyanion holes Biochemistry, 41, 2002
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4XL2
| Crystal structure of oxidized form of thiolase from Clostridium acetobutylicum | Descriptor: | ACETATE ION, Acetyl-CoA acetyltransferase, DI(HYDROXYETHYL)ETHER, ... | Authors: | Kim, S, Ha, S.C, Ahn, J.W, Kim, E.J, Lim, J.H, Kim, K.J. | Deposit date: | 2015-01-13 | Release date: | 2015-10-07 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | Redox-switch regulatory mechanism of thiolase from Clostridium acetobutylicum Nat Commun, 6, 2015
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7PXP
| Benzoylsuccinyl-CoA thiolase | Descriptor: | Benzoylsuccinyl-CoA thiolase subunit, ZINC ION | Authors: | Ermler, U, Heider, H, Weidenweber, S, Demmer, U. | Deposit date: | 2021-10-08 | Release date: | 2022-04-06 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Finis tolueni: a new type of thiolase with an integrated Zn-finger subunit catalyzes the final step of anaerobic toluene metabolism. Febs J., 289, 2022
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6ESQ
| Structure of the acetoacetyl-CoA thiolase/HMG-CoA synthase complex from Methanothermococcus thermolithotrophicus soaked with acetyl-CoA | Descriptor: | CHLORIDE ION, COENZYME A, HydroxyMethylGlutaryl-CoA synthase, ... | Authors: | Voegeli, B, Engilberge, S, Girard, E, Riobe, F, Maury, O, Erb, J.T, Shima, S, Wagner, T. | Deposit date: | 2017-10-24 | Release date: | 2018-03-14 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Archaeal acetoacetyl-CoA thiolase/HMG-CoA synthase complex channels the intermediate via a fused CoA-binding site. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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7PYT
| Benzoylsuccinyl-CoA thiolase with coenzyme A | Descriptor: | 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Benzoylsuccinyl-CoA thiolase subunit, ... | Authors: | Ermler, U, Heider, J, Weidenweber, S, Demmer, U. | Deposit date: | 2021-10-11 | Release date: | 2022-04-06 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Finis tolueni: a new type of thiolase with an integrated Zn-finger subunit catalyzes the final step of anaerobic toluene metabolism. Febs J., 289, 2022
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4XL3
| Crystal structure of reduced form of thiolase from Clostridium acetobutylicum | Descriptor: | Acetyl-CoA acetyltransferase, GLYCEROL | Authors: | Kim, S, Ha, S.C, Ahn, J.W, Kim, E.J, Lim, J.H, Kim, K.J. | Deposit date: | 2015-01-13 | Release date: | 2015-10-07 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Redox-switch regulatory mechanism of thiolase from Clostridium acetobutylicum Nat Commun, 6, 2015
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6ET9
| Structure of the acetoacetyl-CoA-thiolase/HMG-CoA-synthase complex from Methanothermococcus thermolithotrophicus at 2.75 A | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Acetyl-CoA acetyltransferase thiolase, CHLORIDE ION, ... | Authors: | Engilberge, S, Voegeli, B, Girard, E, Riobe, F, Maury, O, Erb, T.J, Shima, S, Wagner, T. | Deposit date: | 2017-10-25 | Release date: | 2018-03-14 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Archaeal acetoacetyl-CoA thiolase/HMG-CoA synthase complex channels the intermediate via a fused CoA-binding site. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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7CW4
| Acetyl-CoA acetyltransferase from Bacillus cereus ATCC 14579 | Descriptor: | Acetyl-CoA acetyltransferase, GLYCEROL | Authors: | Hong, J, Kim, K.J. | Deposit date: | 2020-08-27 | Release date: | 2020-10-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | Crystal structure of an acetyl-CoA acetyltransferase from PHB producing bacterium Bacillus cereus ATCC 14579. Biochem.Biophys.Res.Commun., 533, 2020
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4E1L
| Crystal structure of Acetoacetyl-CoA thiolase (thlA2) from Clostridium difficile | Descriptor: | Acetoacetyl-CoA thiolase 2, IODIDE ION | Authors: | Anderson, S.M, Wawrzak, Z, Kudritska, M, Peterson, S.N, Anderson, W.F, Savchenko, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2012-03-06 | Release date: | 2012-03-21 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: |
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7CW5
| Acetyl-CoA acetyltransferase from Bacillus cereus ATCC 14579 | Descriptor: | Acetyl-CoA acetyltransferase, COENZYME A | Authors: | Hong, J, Kim, K.J. | Deposit date: | 2020-08-27 | Release date: | 2020-10-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of an acetyl-CoA acetyltransferase from PHB producing bacterium Bacillus cereus ATCC 14579. Biochem.Biophys.Res.Commun., 533, 2020
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3SS6
| Crystal structure of the Bacillus anthracis acetyl-CoA acetyltransferase | Descriptor: | Acetyl-CoA acetyltransferase, POTASSIUM ION, SULFATE ION | Authors: | Anderson, S.M, Wawrzak, Z, Onopriyenko, O, Peterson, S.N, Anderson, W.F, Savchenko, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2011-07-07 | Release date: | 2011-07-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structure of the Bacillus anthracis acetyl-CoA acetyltransferase TO BE PUBLISHED
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6L2G
| Crystal structure of Aspergillus fumigatus mitochondrial acetyl-CoA acetyltransferase | Descriptor: | Acetyl-CoA-acetyltransferase, putative | Authors: | Zhang, Y, Wei, W, Raimi, O.G, Ferenbach, A.T, Fang, W. | Deposit date: | 2019-10-03 | Release date: | 2020-02-12 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Aspergillus fumigatus Mitochondrial Acetyl Coenzyme A Acetyltransferase as an Antifungal Target. Appl.Environ.Microbiol., 86, 2020
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6L2C
| Crystal structure of Aspergillus fumigatus mitochondrial acetyl-CoA acetyltransferase in complex with CoA | Descriptor: | Acetyl-CoA-acetyltransferase, putative, COENZYME A | Authors: | Zhang, Y, Wei, W, Raimi, O.G, Ferenbach, A.T, Fang, W. | Deposit date: | 2019-10-03 | Release date: | 2020-02-12 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.44 Å) | Cite: | Aspergillus fumigatus Mitochondrial Acetyl Coenzyme A Acetyltransferase as an Antifungal Target. Appl.Environ.Microbiol., 86, 2020
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4YZO
| Crystal Structure Analysis of Thiolase-like protein, ST0096 from Sulfolobus Tokodaii | Descriptor: | ACETATE ION, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Padmanabhan, B, Manjula, R, Yokoyama, S, Bessho, Y. | Deposit date: | 2015-03-25 | Release date: | 2016-03-30 | Last modified: | 2020-02-19 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal Structure Analysis of Thiolase-like protein, ST0096 from Sulfolobus Tokodaii To Be Published
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4DD5
| Biosynthetic Thiolase (ThlA1) from Clostridium difficile | Descriptor: | Acetyl-CoA acetyltransferase | Authors: | Filippova, E.V, Wawrzak, Z, Kudritska, M, Edwards, A, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2012-01-18 | Release date: | 2012-02-01 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Biosynthetic Thiolase (ThlA1) from Clostridium difficile To be Published
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4ZRC
| Crystal structure of MSM-13, a putative T1-like thiolase from Mycobacterium smegmatis | Descriptor: | Beta-ketothiolase | Authors: | Janardan, N, Harijan, R.K, Keima, T.R, Wierenga, R, Murthy, M.R.N. | Deposit date: | 2015-05-12 | Release date: | 2016-05-18 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural characterization of a mitochondrial 3-ketoacyl-CoA (T1)-like thiolase from Mycobacterium smegmatis Acta Crystallogr.,Sect.D, 71, 2015
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