7OQC
| The U1 part of Saccharomyces cerevisiae spliceosomal pre-A complex (delta BS-A ACT1) | Descriptor: | 56 kDa U1 small nuclear ribonucleoprotein component, ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A), Pre-mRNA-processing factor 39, ... | Authors: | Zhang, Z, Rigo, N, Dybkov, O, Fourmann, J, Will, C.L, Kumar, V, Urlaub, H, Stark, H, Luehrmann, R. | Deposit date: | 2021-06-03 | Release date: | 2021-08-11 | Last modified: | 2021-09-29 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structural insights into how Prp5 proofreads the pre-mRNA branch site. Nature, 596, 2021
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7OQB
| The U2 part of Saccharomyces cerevisiae spliceosomal pre-A complex (delta BS-A ACT1) | Descriptor: | ACT1 pre-mRNA (delta-BS-A), Cold sensitive U2 snRNA suppressor 1, Pre-mRNA-processing ATP-dependent RNA helicase PRP5, ... | Authors: | Zhang, Z, Rigo, N, Dybkov, O, Fourmann, J, Will, C.L, Kumar, V, Urlaub, H, Stark, H, Luehrmann, R. | Deposit date: | 2021-06-03 | Release date: | 2021-08-11 | Last modified: | 2021-09-22 | Method: | ELECTRON MICROSCOPY (9 Å) | Cite: | Structural insights into how Prp5 proofreads the pre-mRNA branch site. Nature, 596, 2021
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7ONB
| Structure of the U2 5' module of the A3'-SSA complex | Descriptor: | MINX, PHD finger-like domain-containing protein 5A, RNU2, ... | Authors: | Cretu, C, Pena, V. | Deposit date: | 2021-05-25 | Release date: | 2021-08-04 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors. Nat Commun, 12, 2021
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7OHX
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7OHW
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7OHV
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7OHS
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7OHR
| Nog1-TAP associated immature ribosomal particle population E from S. cerevisiae | Descriptor: | 25S rRNA, 25S rRNA (cytosine(2870)-C(5))-methyltransferase, 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase, ... | Authors: | Milkereit, P, Poell, G. | Deposit date: | 2021-05-11 | Release date: | 2021-11-10 | Last modified: | 2021-12-08 | Method: | ELECTRON MICROSCOPY (4.72 Å) | Cite: | Analysis of subunit folding contribution of three yeast large ribosomal subunit proteins required for stabilisation and processing of intermediate nuclear rRNA precursors. Plos One, 16, 2021
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7OHQ
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7OHP
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7OCX
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7NAC
| State E2 nucleolar 60S ribosomal biogenesis intermediate - Composite model | Descriptor: | 25S rRNA, 25S rRNA (cytosine(2870)-C(5))-methyltransferase, 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase, ... | Authors: | Cruz, V.E, Sekulski, K, Peddada, N, Erzberger, J.P. | Deposit date: | 2021-06-21 | Release date: | 2022-11-09 | Last modified: | 2022-12-28 | Method: | ELECTRON MICROSCOPY (3.04 Å) | Cite: | Sequence-specific remodeling of a topologically complex RNP substrate by Spb4. Nat.Struct.Mol.Biol., 29, 2022
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7MI2
| Seb1-G476S RNA binding domain | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Rpb7-binding protein seb1 | Authors: | Jacewicz, A, Shuman, S. | Deposit date: | 2021-04-16 | Release date: | 2021-07-14 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Genetic screen for suppression of transcriptional interference identifies a gain-of-function mutation in Pol2 termination factor Seb1. Proc.Natl.Acad.Sci.USA, 118, 2021
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7LRU
| Crystal structure of SFPQ-NONO-SFPQ chimeric protein homodimer | Descriptor: | Splicing factor, proline- and glutamine-rich,Isoform 2 of Non-POU domain-containing octamer-binding protein,Isoform Short of Splicing factor, proline- and glutamine-rich | Authors: | Marshall, A.C, Bond, C.S, Mohnen, I, Knott, G.J. | Deposit date: | 2021-02-17 | Release date: | 2021-05-12 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystal structure of SFPQ-NONO-SFPQ chimeric protein homodimer To Be Published
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7LRQ
| Crystal structure of human SFPQ/NONO heterodimer, conserved DBHS region | Descriptor: | CHLORIDE ION, Non-POU domain-containing octamer-binding protein, Splicing factor, ... | Authors: | Marshall, A.C, Bond, C.S, Mohnen, I. | Deposit date: | 2021-02-17 | Release date: | 2021-05-12 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Paraspeckle subnuclear bodies depend on dynamic heterodimerisation of DBHS RNA-binding proteins via their structured domains. J.Biol.Chem., 298, 2022
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7LMB
| Tetrahymena telomerase T5D5 structure at 3.8 Angstrom | Descriptor: | Telomerase La-related protein p65, Telomerase RNA, Telomerase associated protein p50, ... | Authors: | He, Y, Wang, Y, Liu, B, Helmling, C, Susac, L, Cheng, R, Zhou, Z.H, Feigon, J. | Deposit date: | 2021-02-05 | Release date: | 2021-05-12 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structures of telomerase at several steps of telomere repeat synthesis. Nature, 593, 2021
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7LMA
| Tetrahymena telomerase T3D2 structure at 3.3 Angstrom | Descriptor: | Telomerase La-related protein p65, Telomerase RNA, Telomerase associated protein p50, ... | Authors: | He, Y, Wang, Y, Liu, B, Helmling, C, Susac, L, Cheng, R, Zhou, Z.H, Feigon, J. | Deposit date: | 2021-02-05 | Release date: | 2021-05-12 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structures of telomerase at several steps of telomere repeat synthesis. Nature, 593, 2021
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7LHX
| Human U1A protein with F37M and F77M mutations for improved phasing | Descriptor: | ACETATE ION, BETA-MERCAPTOETHANOL, SODIUM ION, ... | Authors: | Jenkins, J.L, Lippa, G.M, Wedekind, J.E. | Deposit date: | 2021-01-26 | Release date: | 2021-03-17 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Affinity and Structural Analysis of the U1A RNA Recognition Motif with Engineered Methionines to Improve Experimental Phasing Crystals, 11, 2021
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7JLY
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7EVO
| The cryo-EM structure of the human 17S U2 snRNP | Descriptor: | HIV Tat-specific factor 1, PHD finger-like domain-containing protein 5A, RNA helicase, ... | Authors: | Zhang, X, Zhan, X, Shi, Y. | Deposit date: | 2021-05-21 | Release date: | 2022-08-03 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Structural insights into branch site proofreading by human spliceosome. Nat.Struct.Mol.Biol., 2024
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7EB1
| Solution NMR structure of the RRM domain of RNA binding protein RBM3 from homo sapiens | Descriptor: | RNA-binding protein 3 | Authors: | Boral, S, Roy, S, Basak, A.J, Maiti, S, Lee, W, De, S. | Deposit date: | 2021-03-08 | Release date: | 2021-12-08 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural and dynamic studies of the human RNA binding protein RBM3 reveals the molecular basis of its oligomerization and RNA recognition. Febs J., 289, 2022
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7DWH
| Complex structure of SAM-dependent methyltransferase ribozyme | Descriptor: | COPPER (II) ION, RNA (45-MER), S-ADENOSYLMETHIONINE, ... | Authors: | Jiang, H.Y, Gao, Y.Q, Chen, D.R, Murchie, A. | Deposit date: | 2021-01-17 | Release date: | 2021-10-27 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | The identification and characterization of a selected SAM-dependent methyltransferase ribozyme that is present in natural sequences Nat Catal, 4, 2021
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7DVQ
| Cryo-EM Structure of the Activated Human Minor Spliceosome (minor Bact Complex) | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, 5'-O-[(S)-hydroxy{[(R)-hydroxy{[(S)-hydroxy(methoxy)phosphoryl]oxy}phosphoryl]oxy}phosphoryl]guanosine, Armadillo repeat-containing protein 7, ... | Authors: | Bai, R, Wan, R, Wang, L, Xu, K, Zhang, Q, Lei, J, Shi, Y. | Deposit date: | 2021-01-14 | Release date: | 2021-03-31 | Method: | ELECTRON MICROSCOPY (2.89 Å) | Cite: | Structure of the activated human minor spliceosome. Science, 371, 2021
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7DLZ
| Crystal Structure of Methyltransferase Ribozyme | Descriptor: | RNA (45-MER), U1 small nuclear ribonucleoprotein A | Authors: | Gan, J.H, Gao, Y.Q, Jiang, H.Y, Chen, D.R, Murchie, A.I.H. | Deposit date: | 2020-11-30 | Release date: | 2021-10-27 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.002 Å) | Cite: | The identification and characterization of a selected SAM-dependent methyltransferase ribozyme that is present in natural sequences Nat Catal, 4, 2021
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7DCO
| Cryo-EM structure of the activated spliceosome (Bact complex) at an atomic resolution of 2.5 angstrom | Descriptor: | BJ4_G0014900.mRNA.1.CDS.1, BJ4_G0027490.mRNA.1.CDS.1, BJ4_G0037700.mRNA.1.CDS.1, ... | Authors: | Bai, R, Wan, R, Yan, C, Qi, J, Zhang, P, Lei, J, Shi, Y. | Deposit date: | 2020-10-26 | Release date: | 2021-03-17 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Mechanism of spliceosome remodeling by the ATPase/helicase Prp2 and its coactivator Spp2. Science, 371, 2021
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