PDB: 278 resultsInfo pagesStatus searchChemie searchBIRD

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5UMB	Crystal structure of ATPase domain of Malaria GRP78 with ADP bound Descriptor: ADENOSINE-5'-DIPHOSPHATE, Chaperone DnaK, MAGNESIUM ION, ... Authors: Chen, Y, Antoshchenko, T, Pizarro, J.C, Song, J.H, Park, H. Deposit date: 2017-01-26 Release date: 2022-07-27 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Repurposing drugs to target the malaria parasite unfolding protein response. Sci Rep, 8, 2018
7RAX	ATP-binding state of the nucleotide-binding domain of Hsp70 DnaK mutant T199A Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Chaperone protein DnaK, GLYCEROL, ... Authors: Wang, W, Hendrickson, W.A. Deposit date: 2021-07-04 Release date: 2023-07-05 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.41 Å) Cite: Visualization of Hsp70-catalyzed ATP Hydrolysis To Be Published
5TKY	Crystal structure of the co-translational Hsp70 chaperone Ssb in the ATP-bound, open conformation Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Putative uncharacterized protein Authors: Gumiero, A, Gese, G.V, Weyer, F.A, Lapouge, K, Sinning, I. Deposit date: 2016-10-10 Release date: 2016-11-16 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Interaction of the cotranslational Hsp70 Ssb with ribosomal proteins and rRNA depends on its lid domain. Nat Commun, 7, 2016
6ZHI	Structure of the Plasmodium falciparum Hsp70-x substrate binding domain in complex with hydrophobic peptide Descriptor: ASN-ARG-LEU-LEU-LEU-THR-GLY, Heat shock protein 70 Authors: Schmidt, J, Vakonakis, I. Deposit date: 2020-06-23 Release date: 2020-09-09 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (3.25 Å) Cite: Structure of the PfHsp70-x SBD Acta Crystallographica Section F
6NHK	Mortalin nucleotide binding domain in the ADP-bound state Descriptor: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... Authors: Page, R.C, Moseng, M.A, Nix, J.C. Deposit date: 2018-12-23 Release date: 2019-04-17 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.777 Å) Cite: Biophysical Consequences of EVEN-PLUS Syndrome Mutations for the Function of Mortalin. J.Phys.Chem.B, 123, 2019
2KHO	NMR-RDC / XRAY structure of E. coli HSP70 (DNAK) chaperone (1-605) complexed with ADP and substrate Descriptor: Heat shock protein 70 Authors: Zuiderweg, E.R.P, Bertelsen, E.B. Deposit date: 2009-04-10 Release date: 2009-05-12 Last modified: 2021-08-18 Method: SOLUTION NMR Cite: Solution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrate. Proc.Natl.Acad.Sci.USA, 106, 2009
3KVG	Crystal structure of the N-terminal domain of Hsp70 (cgd2_20) from Cryptosporidium parvum in complex with AMPPNP Descriptor: 1,2-ETHANEDIOL, Heat shock 70 (HSP70) protein, PHOSPHATE ION, ... Authors: Wernimont, A.K, Hutchinson, A, Sullivan, H, Lew, J, Bochkarev, A, Arrowsmith, C.H, Bountra, C, Weigelt, J, Edwards, A.M, Hui, R, Pizarro, J.C, Hills, T, Structural Genomics Consortium (SGC) Deposit date: 2009-11-30 Release date: 2010-01-19 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Crystal structure of the N-terminal domain of Hsp70 (cgd2_20) from Cryptosporidium parvum in complex with AMPPNP To be Published
2QWQ	Crystal structure of disulfide-bond-crosslinked complex of bovine hsc70 (1-394aa)R171C and bovine Auxilin (810-910aa)D876C in the AMPPNP hydrolyzed form Descriptor: ACETIC ACID, ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, ... Authors: Jiang, J, Maes, E.G, Wang, L, Taylor, A.B, Hinck, A.P, Lafer, E.M, Sousa, R. Deposit date: 2007-08-10 Release date: 2007-12-18 Last modified: 2021-10-20 Method: X-RAY DIFFRACTION (2.21 Å) Cite: Structural basis of J cochaperone binding and regulation of Hsp70. Mol.Cell, 28, 2007
3L4I	CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF HSP70 (CGD2_20) FROM Cryptosporidium PARVUM IN COMPLEX WITH ADP and inorganic phosphate Descriptor: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ... Authors: Pizarro, J.C, Wernimont, A.K, Hutchinson, A, Sullivan, H, Lew, J, Bochkarev, A, Arrowsmith, C.H, Bountra, C, Weigelt, J, Edwards, A.M, Hui, R, Hills, T, Structural Genomics Consortium (SGC) Deposit date: 2009-12-20 Release date: 2010-01-19 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.2 Å) Cite: CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF HSP70 (CGD2_20) FROM Cryptosporidium PARVUM IN COMPLEX WITH ADP and inorganic phosphate To be Published
2QWL	Crystal structure of bovine hsc70 (1-394aa)in the ADP state Descriptor: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, Heat shock cognate 71 kDa protein, ... Authors: Jiang, J, Maes, E.G, Wang, L, Taylor, A.B, Hinck, A.P, Lafer, E.M, Sousa, R. Deposit date: 2007-08-10 Release date: 2007-12-18 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Structural basis of J cochaperone binding and regulation of Hsp70. Mol.Cell, 28, 2007
5XI9	Solution structure for human HSP70 substrate binding domain Descriptor: Heat shock 70 kDa protein 1A Authors: Hoshikawa, M, Tochio, N, Tate, S. Deposit date: 2017-04-26 Release date: 2018-05-16 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Substrate Binding Switches the Conformation at the Lynchpin Site in the Substrate-Binding Domain of Human Hsp70 to Enable Allosteric Interdomain Communication. Molecules, 23, 2018
5XIR	Solution structure for human HSP70 substrate binding domain L542Y mutant Descriptor: Heat shock 70 kDa protein 1A Authors: Hoshikawa, M, Tochio, N, Tate, S. Deposit date: 2017-04-27 Release date: 2018-05-16 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Substrate Binding Switches the Conformation at the Lynchpin Site in the Substrate-Binding Domain of Human Hsp70 to Enable Allosteric Interdomain Communication. Molecules, 23, 2018
4B9Q	Open conformation of ATP-bound Hsp70 homolog DnaK Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CHAPERONE PROTEIN DNAK, MAGNESIUM ION Authors: Kopp, J, Mayer, M.P, Sinning, I. Deposit date: 2012-09-06 Release date: 2012-11-14 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structure and Dynamics of the ATP-Bound Open Conformation of Hsp70 Chaperones Mol.Cell, 48, 2012
6P2U	Structure of Mortalin-NBD with N6-propargyladenosine-5'-diphosphate Descriptor: 9-{5-O-[(S)-hydroxy(phosphonooxy)phosphoryl]-alpha-D-ribofuranosyl}-N-(prop-2-yn-1-yl)-9H-purin-6-amine, MAGNESIUM ION, PHOSPHATE ION, ... Authors: Moseng, M.A, Page, R.C. Deposit date: 2019-05-22 Release date: 2019-06-19 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2 Å) Cite: 2- and N6-functionalized adenosine-5'-diphosphate analogs for the inhibition of mortalin. Febs Lett., 593, 2019
6PMT	Structure of Mortalin-NBD with adenosine-5'-monophosphate and thiodiphosphate Descriptor: ADENOSINE MONOPHOSPHATE, PHOSPHATE ION, Stress-70 protein, ... Authors: Moseng, M.A, Nix, J.C, Page, R.C. Deposit date: 2019-07-02 Release date: 2020-07-08 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structure of the mortalin nucleotide binding domain in complex with adenosine monophosphate to be published
1YUW	crystal structure of bovine hsc70(aa1-554)E213A/D214A mutant Descriptor: Heat shock cognate 71 kDa protein Authors: Jiang, J, Lafer, E.M, Prasad, K, Sousa, R. Deposit date: 2005-02-14 Release date: 2005-10-04 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural basis of interdomain communication in the Hsc70 chaperone Mol.Cell, 20, 2005
1QQN	D206S MUTANT OF BOVINE 70 KILODALTON HEAT SHOCK PROTEIN Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, D206S MUTANT OF BOVINE 70 KILODALTON HEAT SHOCK PROTEIN, ... Authors: Johnson, E.R, McKay, D.B. Deposit date: 1999-06-07 Release date: 1999-09-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Mapping the role of active site residues for transducing an ATP-induced conformational change in the bovine 70-kDa heat shock cognate protein. Biochemistry, 38, 1999
6RZQ	Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain - ANP-PnP bound state Descriptor: GLYCEROL, Heat shock protein 70, MAGNESIUM ION, ... Authors: Vakonakis, I, Day, J. Deposit date: 2019-06-13 Release date: 2019-10-02 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.81 Å) Cite: ThePlasmodium falciparumHsp70-x chaperone assists the heat stress response of the malaria parasite. Faseb J., 33, 2019
5MB9	Crystal structure of the eukaryotic ribosome associated complex (RAC), a unique Hsp70/Hsp40 pair Descriptor: ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... Authors: Gumiero, A, Weyer, F.A, Valentin Gese, G, Lapouge, K, Sinning, I. Deposit date: 2016-11-07 Release date: 2016-12-28 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Structural insights into a unique Hsp70-Hsp40 interaction in the eukaryotic ribosome-associated complex. Nat. Struct. Mol. Biol., 24, 2017
5MKS	HSP72-NBD bound to compound TCI 8 - Tyr15 in down-conformation Descriptor: 3-[(2~{R},3~{S},4~{R},5~{R})-5-[6-azanyl-8-[(4-chlorophenyl)methylamino]purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]propyl prop-2-enoate, Heat shock 70 kDa protein 1A Authors: Pettinger, J, Westwood, I.M, Cronin, N, Le Bihan, Y.-V, Van Montfort, R.L.M. Deposit date: 2016-12-05 Release date: 2017-03-01 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (1.99 Å) Cite: An Irreversible Inhibitor of HSP72 that Unexpectedly Targets Lysine-56. Angew. Chem. Int. Ed. Engl., 56, 2017
6S02	Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain - ADP bound state Descriptor: ADENOSINE-5'-DIPHOSPHATE, Heat shock protein 70, MAGNESIUM ION Authors: Vakonakis, I, Day, J. Deposit date: 2019-06-13 Release date: 2019-10-02 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.87 Å) Cite: ThePlasmodium falciparumHsp70-x chaperone assists the heat stress response of the malaria parasite. Faseb J., 33, 2019
1U00	HscA substrate binding domain complexed with the IscU recognition peptide ELPPVKIHC Descriptor: Chaperone protein hscA, IscU recognition peptide Authors: Cupp-Vickery, J.R, Peterson, J.C, Ta, D.T, Vickery, L.E. Deposit date: 2004-07-12 Release date: 2004-10-05 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Crystal Structure of the Molecular Chaperone HscA Substrate Binding Domain Complexed with the IscU Recognition Peptide ELPPVKIHC. J.Mol.Biol., 342, 2004
1S3X	The crystal structure of the human Hsp70 ATPase domain Descriptor: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Heat shock 70 kDa protein 1, ... Authors: Sriram, M, Osipiuk, J, Freeman, B, Morimoto, R.I, Joachimiak, A. Deposit date: 2004-01-14 Release date: 2004-01-20 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (1.84 Å) Cite: Human Hsp70 molecular chaperone binds two calcium ions within the ATPase domain Structure, 5, 1997
6SR6	Crystal structure of the RAC core with a pseudo substrate bound to Ssz1 SBD Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Putative heat shock protein, ... Authors: Valentin Gese, G, Lapouge, K, Kopp, J, Sinning, I. Deposit date: 2019-09-05 Release date: 2020-03-25 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.5 Å) Cite: The ribosome-associated complex RAC serves in a relay that directs nascent chains to Ssb. Nat Commun, 11, 2020
5MKR	HSP72-NBD bound to compound TCI 8 - Tyr15 in up-conformation Descriptor: 3-[(2~{R},3~{S},4~{R},5~{R})-5-[6-azanyl-8-[(4-chlorophenyl)methylamino]purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]propyl prop-2-enoate, CITRATE ANION, Heat shock 70 kDa protein 1A Authors: Pettinger, J, Westwood, I.M, Cronin, N, Le Bihan, Y.-V, Van Montfort, R.L.M. Deposit date: 2016-12-05 Release date: 2017-03-01 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (1.87 Å) Cite: An Irreversible Inhibitor of HSP72 that Unexpectedly Targets Lysine-56. Angew. Chem. Int. Ed. Engl., 56, 2017

 

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