PDB: 278 件ウェブページステータス検索Chemie searchBIRD

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4GNI	Structure of the Ssz1 ATPase bound to ATP and Magnesium 分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Putative heat shock protein 著者 Bange, G, Sinning, I. 登録日 2012-08-17 公開日 2012-12-05 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.796 Å) 主引用文献 Structural characterization of a eukaryotic chaperone-the ribosome-associated complex. Nat.Struct.Mol.Biol., 20, 2013
4H5V	HSC70 NBD with Mg 分子名称: ACETATE ION, CHLORIDE ION, GLYCEROL, ... 著者 Stec, B. 登録日 2012-09-18 公開日 2014-03-19 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 New crystal structures of HSC-70 ATP binding domain confirm the role of individual binding pockets and suggest a new method of inhibition. Biochimie, 108, 2015
4EZS	Crystal structure of the substrate binding domain of E.coli DnaK in complex with metchnikowin (residues 20 to 26) 分子名称: Chaperone protein DnaK, Metchnikowin, SULFATE ION 著者 Zahn, M, Straeter, N. 登録日 2012-05-03 公開日 2013-04-24 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural studies of DnaK in complex with proline rich antimicrobial peptides reveal two different peptide binding modes To be Published
4EZY	Crystal structure of the substrate binding domain of E.coli DnaK in complex with the designer peptide NRLILTG 分子名称: Chaperone protein DnaK, SULFATE ION, synthetic peptide NRLILTG 著者 Zahn, M, Straeter, N. 登録日 2012-05-03 公開日 2013-04-17 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structural Studies on the Forward and Reverse Binding Modes of Peptides to the Chaperone DnaK. J.Mol.Biol., 425, 2013
4EZN	Crystal structure of the substrate binding domain of E.coli DnaK in complex with pyrrhocoricin 分子名称: Chaperone protein DnaK, Pyrrhocoricin 著者 Zahn, M, Straeter, N. 登録日 2012-05-03 公開日 2013-04-17 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural Studies on the Forward and Reverse Binding Modes of Peptides to the Chaperone DnaK. J.Mol.Biol., 425, 2013
4EZX	Crystal structure of the substrate binding domain of E.coli DnaK in complex with the designer peptide NRLMLTG 分子名称: Chaperone protein DnaK, SULFATE ION, synthetic peptide NRLMLTG 著者 Zahn, M, Straeter, N. 登録日 2012-05-03 公開日 2013-04-17 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural Studies on the Forward and Reverse Binding Modes of Peptides to the Chaperone DnaK. J.Mol.Biol., 425, 2013
4H5W	HSC70 NBD with betaine 分子名称: ACETATE ION, Heat shock cognate 71 kDa protein, MAGNESIUM ION, ... 著者 Stec, B. 登録日 2012-09-19 公開日 2014-03-19 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 New crystal structures of HSC-70 ATP binding domain confirm the role of individual binding pockets and suggest a new method of inhibition. Biochimie, 108, 2015
4HY9	Crystal structure of the substrate binding domain of E.coli DnaK in complex with pyrrhocoricin_LYZZ (residues 1 to 11) 分子名称: Chaperone protein DnaK, Pyrrhocoricin, SULFATE ION 著者 Zahn, M, Straeter, N. 登録日 2012-11-13 公開日 2013-04-17 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Structural Studies on the Forward and Reverse Binding Modes of Peptides to the Chaperone DnaK. J.Mol.Biol., 425, 2013
4FL9	Crystal Structure of bovine hsc70(aa1-554)E213A/D214A at 1.9A Resolution 分子名称: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Heat shock cognate 71 kDa protein, trimethylamine oxide 著者 Grimm, C. 登録日 2012-06-14 公開日 2013-10-02 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.901 Å) 主引用文献 Crystal Structure of bovine hsc70(aa1-554)E213A/D214A at 1.9A Resolution TO BE PUBLISHED
4H5T	HSC70 NBD with ADP and Mg 分子名称: ADENOSINE-5'-DIPHOSPHATE, Heat shock cognate 71 kDa protein, MAGNESIUM ION, ... 著者 Stec, B. 登録日 2012-09-18 公開日 2014-03-19 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 New crystal structures of HSC-70 ATP binding domain confirm the role of individual binding pockets and suggest a new method of inhibition. Biochimie, 108, 2015
4H5N	HSC70 NBD with PO4, Na, Cl 分子名称: CHLORIDE ION, GLYCEROL, Heat shock cognate 71 kDa protein, ... 著者 Stec, B. 登録日 2012-09-18 公開日 2014-03-19 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 New crystal structures of HSC-70 ATP binding domain confirm the role of individual binding pockets and suggest a new method of inhibition. Biochimie, 108, 2015
4H5R	HSC70 NBD with Na, Cl and glycerol 分子名称: CHLORIDE ION, GLYCEROL, Heat shock cognate 71 kDa protein, ... 著者 Stec, B. 登録日 2012-09-18 公開日 2014-03-19 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 New crystal structures of HSC-70 ATP binding domain confirm the role of individual binding pockets and suggest a new method of inhibition. Biochimie, 108, 2015
4HYB	Crystal structure of the substrate binding domain of E.coli DnaK in complex with pyrrhocoricin_LYZI (residues 1 to 10) 分子名称: Chaperone protein DnaK, Pyrrhocoricin, SULFATE ION 著者 Zahn, M, Straeter, N. 登録日 2012-11-13 公開日 2013-04-17 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural Studies on the Forward and Reverse Binding Modes of Peptides to the Chaperone DnaK. J.Mol.Biol., 425, 2013
5AQX	Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues 分子名称: (1R,2S,3R,5R)-3-((5-(benzyloxy)quinazolin-4-yl)amino)-5-(hydroxymethyl)cyclopentane-1,2-diol, CHLORIDE ION, DIMETHYL SULFOXIDE, ... 著者 Jones, A.M, Westwood, I.M, Osborne, J.D, Matthews, T.P, Cheeseman, M.D, Rowlands, M.G, Jeganathan, F, Burke, R, Lee, D, Kadi, N, Liu, M, Richards, M, McAndrew, C, Yahya, N, Dobson, S.E, Jones, K, Workman, P, Collins, I, van Montfort, R.L.M. 登録日 2015-09-22 公開日 2016-10-05 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.12 Å) 主引用文献 A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms. Sci Rep, 6, 2016
5AR0	HSP72 with adenosine-derived inhibitor 分子名称: (2R,3R,4S,5R)-2-(6-amino-8-((quinolin-7-ylmethyl)amino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol, CHLORIDE ION, DIMETHYL SULFOXIDE, ... 著者 Cheeseman, M.D, Westwood, I.M, Barbeau, O, Rowlands, M.G, Jones, A.M, Jeganathan, F, Burke, R, Dobson, S.E, Workman, P, Collins, I, van Montfort, R.L.M, Jones, K. 登録日 2015-09-22 公開日 2016-05-11 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Exploiting Protein Conformational Change to Optimize Adenosine-Derived Inhibitors of Hsp70. J.Med.Chem., 59, 2016
5BPL	Crystal structure of ADP and Pi bound human Hsp70 NBD mutant R272K. 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ... 著者 Narayanan, D, Engh, R.A. 登録日 2015-05-28 公開日 2016-09-14 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Nucleotide binding to variants of the HSP70-NBD. To Be Published
5BPN	Crystal structure of nucleotide-free human Hsp70 NBD double mutant E268Q+R272K. 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, Heat shock 70 kDa protein 1A, ... 著者 Narayanan, D, Engh, R.A. 登録日 2015-05-28 公開日 2016-09-14 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Nucleotide binding to variants of the HSP70-NBD. To Be Published
5BN8	Crystal structure of nucleotide-free human Hsp70 NBD. 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, Heat shock 70 kDa protein 1A, ... 著者 Narayanan, D, Engh, R.A. 登録日 2015-05-25 公開日 2016-09-14 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.34 Å) 主引用文献 Nucleotide binding to variants of the HSP70-NBD. To Be Published
5BPM	Crystal structure of unhydrolyzed ATP bound human Hsp70 NBD double mutant E268Q+R272K. 分子名称: ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, Heat shock 70 kDa protein 1A, ... 著者 Narayanan, D, Engh, R.A. 登録日 2015-05-28 公開日 2016-09-14 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Nucleotide binding to variants of the HSP70-NBD. To Be Published
5BN9	Crystal structure of ADP bound human Hsp70 NBD mutant R272K. 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ... 著者 Narayanan, D, Engh, R.A. 登録日 2015-05-25 公開日 2016-09-14 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.689 Å) 主引用文献 Nucleotide binding to variants of the HSP70-NBD. To Be Published
5AQZ	HSP72 with adenosine-derived inhibitor 分子名称: 1,2-ETHANEDIOL, HEAT SHOCK 70 KDA PROTEIN 1A, SANGIVAMYCIN 著者 Cheeseman, M.D, Westwood, I.M, Barbeau, O, Rowlands, M.G, Jones, A.M, Jeganathan, F, Burke, R, Dobson, S.E, Workman, P, Collins, I, van Montfort, R.L.M, Jones, K. 登録日 2015-09-22 公開日 2016-05-11 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Exploiting Protein Conformational Change to Optimize Adenosine-Derived Inhibitors of Hsp70. J.Med.Chem., 59, 2016
5AQW	Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues 分子名称: (1S,2R,3R,5R)-3-(hydroxymethyl)-5-(quinazolin-4-ylamino)cyclopentane-1,2-diol, (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, 1,2-ETHANEDIOL, ... 著者 Jones, A.M, Westwood, I.M, Osborne, J.D, Matthews, T.P, Cheeseman, M.D, Rowlands, M.G, Jeganathan, F, Burke, R, Lee, D, Kadi, N, Liu, M, Richards, M, McAndrew, C, Yahya, N, Dobson, S.E, Jones, K, Workman, P, Collins, I, van Montfort, R.L.M. 登録日 2015-09-22 公開日 2016-10-05 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms. Sci Rep, 6, 2016
5AQY	Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues 分子名称: 1,2-ETHANEDIOL, ADENOSINE, DIMETHYL SULFOXIDE, ... 著者 Jones, A.M, Westwood, I.M, Osborne, J.D, Matthews, T.P, Cheeseman, M.D, Rowlands, M.G, Jeganathan, F, Burke, R, Lee, D, Kadi, N, Liu, M, Richards, M, McAndrew, C, Yahya, N, Dobson, S.E, Jones, K, Workman, P, Collins, I, van Montfort, R.L.M. 登録日 2015-09-22 公開日 2016-10-05 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.56 Å) 主引用文献 A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms. Sci Rep, 6, 2016
7OLC	Thermophilic eukaryotic 80S ribosome at idle POST state 分子名称: 18S rRNA, 26S rRNA, 40S ribosomal protein S0, ... 著者 Kisonaite, M, Wild, K, Sinning, I. 登録日 2021-05-19 公開日 2022-01-26 最終更新日 2022-04-06 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation. Nat Commun, 13, 2022
4E81	Crystal structure of the substrate binding domain of E.coli DnaK in complex with a short apidaecin peptide 分子名称: Chaperone protein DnaK, SULFATE ION, apidaecin peptide fragment 著者 Zahn, M, Straeter, N. 登録日 2012-03-19 公開日 2012-05-30 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Api88 is a novel antibacterial designer Peptide to treat systemic infections with multidrug-resistant gram-negative pathogens. Acs Chem.Biol., 7, 2012

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