7QKS
| |
7QKR
| Cryo-EM structure of ABC transporter STE6-2p from Pichia pastoris with Verapamil at 3.2 A resolution | Descriptor: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, Dexverapamil, MAGNESIUM ION, ... | Authors: | Schleker, E.S.M, Reinhart, C. | Deposit date: | 2021-12-18 | Release date: | 2022-10-26 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural and functional investigation of ABC transporter STE6-2p from Pichia pastoris reveals unexpected interaction with sterol molecules. Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
7R8E
| The structure of human ABCG1 E242Q complexed with ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL, Isoform 4 of ATP-binding cassette sub-family G member 1, ... | Authors: | Sun, Y, Li, X, Long, T. | Deposit date: | 2021-06-26 | Release date: | 2021-09-08 | Method: | ELECTRON MICROSCOPY (3.68 Å) | Cite: | Molecular basis of cholesterol efflux via ABCG subfamily transporters. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7R8C
| The structure of human ABCG1 | Descriptor: | Isoform 4 of ATP-binding cassette sub-family G member 1 | Authors: | Sun, Y, Li, X, Long, T. | Deposit date: | 2021-06-26 | Release date: | 2021-09-08 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Molecular basis of cholesterol efflux via ABCG subfamily transporters. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7R87
| The structure of human ABCG5-WT/ABCG8-I419E | Descriptor: | 2C7 Fab heavy chain, 2C7 Fab light chain, ATP-binding cassette sub-family G member 5, ... | Authors: | Sun, Y, Li, X, Long, T. | Deposit date: | 2021-06-26 | Release date: | 2021-09-08 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Molecular basis of cholesterol efflux via ABCG subfamily transporters. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7R8D
| The structure of human ABCG1 E242Q with cholesterol | Descriptor: | CHOLESTEROL, Isoform 4 of ATP-binding cassette sub-family G member 1 | Authors: | Sun, Y, Li, X, Long, T. | Deposit date: | 2021-06-26 | Release date: | 2021-09-08 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Molecular basis of cholesterol efflux via ABCG subfamily transporters. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7R8B
| The structure of human ABCG5/ABCG8 supplemented with cholesterol | Descriptor: | 2C7 Fab heavy chain, 2C7 Fab light chain, ATP-binding cassette sub-family G member 5, ... | Authors: | Sun, Y, Li, X, Long, T. | Deposit date: | 2021-06-26 | Release date: | 2021-09-08 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Molecular basis of cholesterol efflux via ABCG subfamily transporters. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7R8A
| The structure of human ABCG5/ABCG8 purified from mammalian cells | Descriptor: | 2C7 Fab heavy chain, 2C7 Fab light chain, ATP-binding cassette sub-family G member 5, ... | Authors: | Sun, Y, Li, X, Long, T. | Deposit date: | 2021-06-26 | Release date: | 2021-09-08 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Molecular basis of cholesterol efflux via ABCG subfamily transporters. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7R88
| The structure of human ABCG5-I529W/ABCG8-WT | Descriptor: | 2C7 Fab heavy chain, 2C7 Fab light chain, ATP-binding cassette sub-family G member 5, ... | Authors: | Sun, Y, Li, X, Long, T. | Deposit date: | 2021-06-26 | Release date: | 2021-09-08 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Molecular basis of cholesterol efflux via ABCG subfamily transporters. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7R89
| The structure of human ABCG5/ABCG8 purified from yeast | Descriptor: | 2C7 Fab heavy chain, 2C7 Fab light chain, ATP-binding cassette sub-family G member 5, ... | Authors: | Sun, Y, Li, X, Long, T. | Deposit date: | 2021-06-26 | Release date: | 2021-09-08 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Molecular basis of cholesterol efflux via ABCG subfamily transporters. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7RIT
| Drug-free A. baumannii MsbA | Descriptor: | ATP-dependent lipid A-core flippase | Authors: | Thelot, F, Liao, M. | Deposit date: | 2021-07-20 | Release date: | 2021-10-06 | Last modified: | 2021-11-10 | Method: | ELECTRON MICROSCOPY (5.2 Å) | Cite: | Distinct allosteric mechanisms of first-generation MsbA inhibitors. Science, 374, 2021
|
|
7RRA
| |
7RR9
| Cryo-EM Structure of Nanodisc reconstituted ABCD1 in nucleotide bound outward open conformation | Descriptor: | ATP-binding cassette sub-family D member 1, CHOLESTEROL, MAGNESIUM ION, ... | Authors: | Alam, A, Le, L.T.M, Thompson, J.R. | Deposit date: | 2021-08-09 | Release date: | 2022-01-19 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structures of the human peroxisomal fatty acid transporter ABCD1 in a lipid environment Commun Biol, 5, 2022
|
|
7ROQ
| Alternative Structure of Human ABCA1 | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Aller, S.G. | Deposit date: | 2021-08-01 | Release date: | 2022-01-19 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Refined ABCA1 with Domain-swapped Regulatory Domains Plos One, 2022
|
|
7SHN
| Cryo-EM structure of oleoyl-CoA-bound human peroxisomal fatty acid transporter ABCD1 | Descriptor: | ATP-binding cassette sub-family D member 1, S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9Z)-octadec-9-enethioate (non-preferred name) | Authors: | Wang, R, Li, X. | Deposit date: | 2021-10-09 | Release date: | 2021-11-03 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis of acyl-CoA transport across the peroxisomal membrane by human ABCD1. Cell Res., 32, 2022
|
|
7SHM
| |
7S5V
| Human KATP channel in open conformation, focused on SUR | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... | Authors: | Zhao, C, MacKinnon, R. | Deposit date: | 2021-09-12 | Release date: | 2021-12-01 | Last modified: | 2021-12-08 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Molecular structure of an open human K ATP channel. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7S61
| Human KATP channel in open conformation, focused on Kir and one SUR, position 5 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... | Authors: | Zhao, C, MacKinnon, R. | Deposit date: | 2021-09-12 | Release date: | 2021-12-01 | Last modified: | 2021-12-08 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Molecular structure of an open human K ATP channel. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7S60
| Human KATP channel in open conformation, focused on Kir and one SUR, position 4 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... | Authors: | Zhao, C, MacKinnon, R. | Deposit date: | 2021-09-12 | Release date: | 2021-12-01 | Last modified: | 2021-12-08 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Molecular structure of an open human K ATP channel. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7S5Z
| Human KATP channel in open conformation, focused on Kir and one SUR, position 3 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... | Authors: | Zhao, C, MacKinnon, R. | Deposit date: | 2021-09-12 | Release date: | 2021-12-01 | Last modified: | 2021-12-08 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Molecular structure of an open human K ATP channel. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7S5Y
| Human KATP channel in open conformation, focused on Kir and one SUR, position 2 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... | Authors: | Zhao, C, MacKinnon, R. | Deposit date: | 2021-09-12 | Release date: | 2021-12-01 | Last modified: | 2021-12-08 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Molecular structure of an open human K ATP channel. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7S5X
| Human KATP channel in open conformation, focused on Kir and one SUR, position 1 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... | Authors: | Zhao, C, MacKinnon, R. | Deposit date: | 2021-09-12 | Release date: | 2021-12-01 | Last modified: | 2021-12-08 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Molecular structure of an open human K ATP channel. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7SEL
| E. coli MsbA in complex with LPS and inhibitor G7090 (compound 3) | Descriptor: | (2E)-3-{7-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-1-methylnaphthalen-2-yl}prop-2-enoic acid, (2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-[(2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-carboxy-2-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-5-[[(3~{R})-3-dodecanoyloxytetradecanoyl]amino]-6-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-3-oxidanyl-5-[[(3~{R})-3-oxidanyltetradecanoyl]amino]-4-[(3~{R})-3-oxidanyltetradecanoyl]oxy-6-phosphonooxy-oxan-2-yl]methoxy]-3-phosphonooxy-4-[(3~{R})-3-tetradecanoyloxytetradecanoyl]oxy-oxan-2-yl]methoxy]-5-oxidanyl-oxan-4-yl]oxy-4,5-bis(oxidanyl)oxane-2-carboxylic acid, ATP-dependent lipid A-core flippase | Authors: | Payandeh, J, Koth, C.M, Verma, V.A. | Deposit date: | 2021-09-30 | Release date: | 2022-03-09 | Last modified: | 2022-03-23 | Method: | X-RAY DIFFRACTION (2.978 Å) | Cite: | Discovery of Inhibitors of the Lipopolysaccharide Transporter MsbA: From a Screening Hit to Potent Wild-Type Gram-Negative Activity. J.Med.Chem., 65, 2022
|
|
7SGR
| Structure of hemolysin A secretion system HlyB/D complex | Descriptor: | Alpha-hemolysin translocation ATP-binding protein HlyB, Membrane fusion protein (MFP) family protein,Hemolysin secretion protein D, chromosomal, ... | Authors: | Zhao, H, Chen, J. | Deposit date: | 2021-10-07 | Release date: | 2022-09-14 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | The hemolysin A secretion system is a multi-engine pump containing three ABC transporters. Cell, 185, 2022
|
|
7SVD
| |