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5YVO	Human Glutathione Transferase Omega1 covalently bound to ML175 inhibitor Descriptor: ACETATE ION, Glutathione S-transferase omega-1, N-{3-[(2-chloro-acetyl)-(4-nitro-phenyl)-amino]-propyl}-2,2,2-trifluoro-acetamide, ... Authors: Saisawang, C, Ketterman, A, Wongsantichon, J. Deposit date: 2017-11-27 Release date: 2018-11-28 Last modified: 2022-04-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Glutathione transferase Omega 1-1 (GSTO1-1) modulates Akt and MEK1/2 signaling in human neuroblastoma cell SH-SY5Y. Proteins, 87, 2019
5V3Q	Human GSTO1-1 complexed with ML175 Descriptor: Glutathione S-transferase omega-1, N-{3-[(2-chloro-acetyl)-(4-nitro-phenyl)-amino]-propyl}-2,2,2-trifluoro-acetamide, SULFATE ION Authors: Oakley, A.J. Deposit date: 2017-03-07 Release date: 2017-12-20 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.25 Å) Cite: GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity. Sci Rep, 7, 2017
7XJR	MLXase AlXyn26A Descriptor: AlXyn26A Authors: Zhang, Y.Z, Chen, X.L, Zhao, F, Yu, C.M. Deposit date: 2022-04-18 Release date: 2023-04-26 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.85 Å) Cite: A novel class of xylanases specifically degrade marine red algal beta 1,3/1,4-mixed-linkage xylan. J.Biol.Chem., 299, 2023
7XS3	AlXyn26A E243A-X3X4X Descriptor: AlXyn26A E243A-X3X4X, beta-D-xylopyranose-(1-3)-beta-D-xylopyranose-(1-4)-beta-D-xylopyranose Authors: Zhang, Y.Z, Chen, X.L, Zhao, F, Yu, C.M. Deposit date: 2022-05-12 Release date: 2023-05-17 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.9 Å) Cite: A novel class of xylanases specifically degrade marine red algal beta 1,3/1,4-mixed-linkage xylan. J.Biol.Chem., 299, 2023
5F74	Crystal structure of ChREBP:14-3-3 complex bound with AMP Descriptor: 14-3-3 protein beta/alpha, ADENOSINE MONOPHOSPHATE, Carbohydrate-responsive element-binding protein Authors: Jung, H, Uyeda, K. Deposit date: 2015-12-07 Release date: 2016-03-23 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Metabolite Regulation of Nuclear Localization of Carbohydrate-response Element-binding Protein (ChREBP): ROLE OF AMP AS AN ALLOSTERIC INHIBITOR. J.Biol.Chem., 291, 2016
6YGJ	small-molecule stabilizer of 14-3-3 and the Carbohydrate Response Element Binding Protein (ChREBP) protein-protein interaction Descriptor: 14-3-3 protein beta/alpha, Carbohydrate-responsive element-binding protein, [2-[2-oxidanylidene-2-(2-phenylethylamino)ethoxy]phenyl]phosphonic acid Authors: Ottmann, C, Visser, E.J. Deposit date: 2020-03-27 Release date: 2020-09-16 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.07 Å) Cite: Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein-protein interactions. Nat Commun, 11, 2020
8BTQ	Small molecule stabilizer for 14-3-3/ChREBP (Cmd1-soaking) Descriptor: 14-3-3 protein sigma, Carbohydrate-responsive element-binding protein, MAGNESIUM ION, ... Authors: Pennings, M.A.M, Visser, E.J, Ottmann, C. Deposit date: 2022-11-29 Release date: 2024-05-01 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity. Biorxiv, 2024
4GNT	Complex of ChREBP and 14-3-3beta Descriptor: 14-3-3 protein beta/alpha, Carbohydrate-responsive element-binding protein, SULFATE ION Authors: Zhang, H, Huang, N. Deposit date: 2012-08-17 Release date: 2012-10-24 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.41 Å) Cite: Crystal Structure of Carbohydrate Response Element Binding Protein (ChREBP) in complex with 14-3-3b To be Published