PDB: 6 件ウェブページステータス検索Chemie searchBIRD

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6DC0	Tribbles (TRIB1) pseudokinase fused to CCAAT-enhancer binding protein (C/EBPalpha) degron 分子名称: Tribbles homolog 1,CCAAT/enhancer-binding protein alpha 著者 Jamieson, S.A, Brewster, J.L, Mace, P.D. 登録日 2018-05-03 公開日 2018-10-10 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Substrate binding allosterically relieves autoinhibition of the pseudokinase TRIB1. Sci Signal, 11, 2018
1NWQ	CRYSTAL STRUCTURE OF C/EBPALPHA-DNA COMPLEX 分子名称: 5'-D(*AP*AP*AP*CP*TP*GP*GP*AP*TP*TP*GP*CP*GP*CP*AP*AP*TP*AP*GP*GP*A)-3', 5'-D(*TP*TP*CP*CP*TP*AP*TP*TP*GP*CP*GP*CP*AP*AP*TP*CP*CP*AP*GP*TP*T)-3', CCAAT/enhancer binding protein alpha 著者 Miller, M, Shuman, J.D, Sebastian, T, Dauter, Z, Johnson, P.F. 登録日 2003-02-06 公開日 2003-05-13 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural Basis for DNA Recognition by the Basic Region Leucine Zipper Transcription Factor CCAAT/enhancer Binding Protein Alpha J.Biol.Chem., 278, 2003
8K8C	Crystal structure of C/EBPalpha BZIP domain bound to a high affinity DNA 分子名称: CCAAT/enhancer-binding protein alpha, DNA (5'-D(*CP*AP*TP*TP*AP*CP*GP*TP*AP*AP*TP*GP*A)-3'), DNA (5'-D(*CP*AP*TP*TP*AP*CP*GP*TP*AP*AP*TP*GP*T)-3'), ... 著者 Min, J.R, Chen, S.Z, Liu, K. 登録日 2023-07-29 公開日 2024-03-06 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 Structural basis for specific DNA sequence recognition by the transcription factor NFIL3. J.Biol.Chem., 300, 2024
4QL1	Crystal structure of human WDR5 in complex with compound OICR-9429 分子名称: 1,2-ETHANEDIOL, GLYCEROL, N-(4-(4-methylpiperazin-1-yl)-3'-(morpholinomethyl)-[1,1'-biphenyl]-3-yl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide, ... 著者 Dong, A, Dombrovski, L, Walker, J.R, Getlik, M, Kuznetsova, E, Smil, D, Barsyte, D, Li, F, Poda, G, Senisterra, G, Marcellus, R, Al-Awar, R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Schapira, M, Vedadi, M, Wu, H, Structural Genomics Consortium (SGC) 登録日 2014-06-10 公開日 2014-12-17 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Pharmacological targeting of the Wdr5-MLL interaction in C/EBP alpha N-terminal leukemia. Nat.Chem.Biol., 11, 2015
6Q6F	Crystal structure of IDH1 R132H in complex with HMS101 分子名称: (2~{R})-2-[2-[(3~{R})-3-(4-fluorophenyl)pyrrolidin-1-yl]ethyl]-1,4-dimethyl-piperazine, Isocitrate dehydrogenase [NADP] cytoplasmic 著者 Chaturvedi, A, Goparaju, R, Gupta, C, Kluenemann, T, Araujo Cruz, M.M, Kloos, A, Goerlich, K, Schottmann, R, Struys, E.A, Ganser, A, Preller, M, Heuser, M. 登録日 2018-12-10 公開日 2019-10-16 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 In vivo efficacy of mutant IDH1 inhibitor HMS-101 and structural resolution of distinct binding site. Leukemia, 34, 2020
4CRL	Crystal structure of human CDK8-Cyclin C in complex with cortistatin A 分子名称: CORTISTATIN A, CYCLIN-C, CYCLIN-DEPENDENT KINASE 8, ... 著者 Myers, A.G, Shair, M.D. 登録日 2014-02-27 公開日 2015-09-23 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Mediator Kinase Inhibition Further Activates Super-Enhancer- Associated Genes in Aml Nature, 526, 2015