PDB: 116 resultsInfo pagesStatus searchChemie searchBIRD

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7T0T	Crystal structure of the BCL6 BTB domain in complex with OICR-10562 Descriptor: DIMETHYL SULFOXIDE, Isoform 2 of B-cell lymphoma 6 protein, N-[5-chloro-2-(morpholin-4-yl)pyridin-4-yl]-2-[5-(3-cyano-4-hydroxy-5-methylphenyl)-3-methyl-2-(1-methyl-1H-pyrazol-4-yl)-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl]acetamide Authors: Kuntz, D.A, Prive, G.G. Deposit date: 2021-11-30 Release date: 2022-12-14 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of the BCL6 BTB domain in complex with OICR-10562 To Be Published
6XXS	Crystal structure of an NCoR1BBD2-BCL6BTB chimera in complex with the NcoR1 BBD1 corepressor peptide. Descriptor: B-cell lymphoma 6 protein, Nuclear receptor corepressor 1 Authors: Zacharchenko, T, Wright, S.C. Deposit date: 2020-01-28 Release date: 2020-12-02 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (3.25 Å) Cite: Functionalization of the BCL6 BTB domain into a noncovalent crystallization chaperone. Iucrj, 8, 2021
6XWF	Crystal structure of an NCoR1BBD2-BCL6BTB chimera Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, B-cell lymphoma 6 protein, CHLORIDE ION Authors: Zacharchenko, T, Wright, S.C. Deposit date: 2020-01-23 Release date: 2020-12-02 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Functionalization of the BCL6 BTB domain into a noncovalent crystallization chaperone. Iucrj, 8, 2021
6Y17	Crystal structure of an NCoR1BBD2-BCL6BTB chimera in complex with nebulinSH3-NCoR1BBD1 Descriptor: Nebulin,Nuclear receptor corepressor 1, Nuclear receptor corepressor 1,B-cell lymphoma 6 protein, SODIUM ION Authors: Zacharchenko, T, Wright, S.C. Deposit date: 2020-02-11 Release date: 2020-12-02 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.56 Å) Cite: Functionalization of the BCL6 BTB domain into a noncovalent crystallization chaperone. Iucrj, 8, 2021
6ZBU	Crystal structure of an NCoR1BBD2-BCL6BTB chimera in complex with the NcoR1 BBD1 corepressor peptide Descriptor: GLYCEROL, Nuclear receptor corepressor 1, Nuclear receptor corepressor 1,B-cell lymphoma 6 protein, ... Authors: Zacharchenko, T, Wright, S.C. Deposit date: 2020-06-09 Release date: 2020-12-02 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.46 Å) Cite: Functionalization of the BCL6 BTB domain into a noncovalent crystallization chaperone. Iucrj, 8, 2021
7LZR	Crystal structure of the BCL6 BTB domain in complex with OICR-10256 Descriptor: B-cell lymphoma 6 protein, CHLORIDE ION, GLYCEROL, ... Authors: Kuntz, D.A, Prive, G.G. Deposit date: 2021-03-10 Release date: 2022-03-16 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.34 Å) Cite: Crystal structure of the BCL6 BTB domain in complex with OICR-10256 To Be Published
7RV5	Crystal structure of the BCL6 BTB domain in complex with OICR-9287 Descriptor: 2-[2-(4-benzylpiperidin-1-yl)-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-N-(3-chloropyridin-4-yl)acetamide, Isoform 2 of B-cell lymphoma 6 protein Authors: Kuntz, D.A, Prive, G.G. Deposit date: 2021-08-18 Release date: 2022-08-24 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.21 Å) Cite: Structure of the BCL6 BTB domain To Be Published
7RV3	Crystal structure of the BCL6 BTB domain in complex with OICR-9124 Descriptor: CHLORIDE ION, Isoform 2 of B-cell lymphoma 6 protein, N-(3-chloropyridin-4-yl)-2-[2-(morpholin-4-yl)-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl]acetamide, ... Authors: Kuntz, D.A, Prive, G.G. Deposit date: 2021-08-18 Release date: 2022-08-24 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Structure of the BCL6 BTB domain To Be Published
7RV9	Crystal structure of the BCL6 BTB domain in complex with OICR-10269 Descriptor: DIMETHYL SULFOXIDE, Isoform 2 of B-cell lymphoma 6 protein, N-[5-chloro-2-(4-methylpiperazin-1-yl)pyridin-4-yl]-2-{5-(3-cyano-4-hydroxy-5-methylphenyl)-3-[3-(1-methyl-1H-pyrazol-4-yl)prop-2-yn-1-yl]-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl}acetamide Authors: Kuntz, D.A, Prive, G.G. Deposit date: 2021-08-18 Release date: 2022-08-24 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Structure of the BCL6 BTB domain To Be Published
7RV6	Crystal structure of the BCL6 BTB domain in complex with OICR-9288 Descriptor: DIMETHYL SULFOXIDE, GLYCEROL, Isoform 2 of B-cell lymphoma 6 protein, ... Authors: Kuntz, D.A, Prive, G.G. Deposit date: 2021-08-18 Release date: 2022-08-24 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.683 Å) Cite: Structure of the BCL6 BTB domain To Be Published
7RV8	Crystal structure of the BCL6 BTB domain in complex with OICR-10268 Descriptor: DIMETHYL SULFOXIDE, Isoform 2 of B-cell lymphoma 6 protein, N-[5-chloro-2-(morpholin-4-yl)pyridin-4-yl]-2-{5-(3-cyano-4-hydroxy-5-methylphenyl)-3-[3-(1-methyl-1H-pyrazol-4-yl)prop-2-yn-1-yl]-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl}acetamide Authors: Kuntz, D.A, Prive, G.G. Deposit date: 2021-08-18 Release date: 2022-08-24 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.25 Å) Cite: Structure of the BCL6 BTB domain To Be Published
7RV4	Crystal structure of the BCL6 BTB domain in complex with OICR-9153 Descriptor: CHLORIDE ION, DIMETHYL SULFOXIDE, Isoform 2 of B-cell lymphoma 6 protein, ... Authors: Kuntz, D.A, Prive, G.G. Deposit date: 2021-08-18 Release date: 2022-08-24 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.25 Å) Cite: Structure of the BCL6 BTB domain To Be Published
7RV7	Crystal structure of the BCL6 BTB domain in complex with OICR-9322 Descriptor: CALCIUM ION, GLYCEROL, Isoform 2 of B-cell lymphoma 6 protein, ... Authors: Kuntz, D.A, Prive, G.G. Deposit date: 2021-08-18 Release date: 2022-08-24 Method: X-RAY DIFFRACTION (1.63 Å) Cite: Structure of the BCL6 BTB domain To Be Published
7RV0	Crystal structure of the BCL6 BTB domain in complex with OICR-8446 Descriptor: B-cell lymphoma 6 protein, CHLORIDE ION, FORMIC ACID, ... Authors: Kuntz, D.A, Prive, G.G. Deposit date: 2021-08-18 Release date: 2022-11-09 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Crystal structure of the BCL6 BTB domain in complex with OICR-8446 To Be Published
7RUY	Crystal structure of the BCL6 BTB domain in complex with OICR-8388 Descriptor: B-cell lymphoma 6 protein, FORMIC ACID, N-(3-chloropyridin-4-yl)-2-(2-{[(2,4-dimethoxyphenyl)methyl]amino}-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)acetamide Authors: Kuntz, D.A, Prive, G.G. Deposit date: 2021-08-18 Release date: 2022-11-09 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.27 Å) Cite: Crystal structure of the BCL6 BTB domain in complex with OICR-8388 To Be Published
7RV2	Crystal structure of the BCL6 BTB domain in complex with OICR-8828 Descriptor: B-cell lymphoma 6 protein, CHLORIDE ION, DIMETHYL SULFOXIDE, ... Authors: Kuntz, D.A, Prive, G.G. Deposit date: 2021-08-18 Release date: 2022-11-09 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.29 Å) Cite: Crystal structure of the BCL6 BTB domain in complex with OICR-8828 To Be Published
7RUZ	Crystal structure of the BCL6 BTB domain in complex with OICR-8445 Descriptor: 2-[2-(benzylamino)-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-N-(3-chloropyridin-4-yl)acetamide, B-cell lymphoma 6 protein, CHLORIDE ION, ... Authors: Kuntz, D.A, Prive, G.G. Deposit date: 2021-08-18 Release date: 2022-11-09 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.62 Å) Cite: Crystal structure of the BCL6 BTB domain in complex with OICR-8445 To Be Published
7RUX	Crystal structure of the BCL6 BTB domain in complex with OICR-8311 Descriptor: B-cell lymphoma 6 protein, FORMIC ACID, N-(3-chloropyridin-4-yl)-2-(3-(cyclopropylmethyl)-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)acetamide Authors: Kuntz, D.A, Prive, G.G. Deposit date: 2021-08-18 Release date: 2022-11-09 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Crystal structure of the BCL6 BTB domain in complex with OICR-8311 To Be Published
7RV1	Crystal structure of the BCL6 BTB domain in complex with OICR-8826 Descriptor: (E)-3-(7-(2-((3-chloropyridin-4-yl)amino)-2-oxoethyl)-3-(3-(1-methyl-1H-pyrazol-4-yl)prop-2-yn-1-yl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)acrylamide, B-cell lymphoma 6 protein, DIMETHYL SULFOXIDE, ... Authors: Kuntz, D.A, Prive, G.G. Deposit date: 2021-08-18 Release date: 2022-11-09 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.17 Å) Cite: Crystal structure of the BCL6 BTB domain in complex with OICR-8826 To Be Published
7RUW	Crystal structure of the BCL6 BTB domain in complex with OICR-7859 Descriptor: 2-(2-amino-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-N-(3-chloropyridin-4-yl)acetamide, B-cell lymphoma 6 protein, CHLORIDE ION, ... Authors: Kuntz, D.A, Prive, G.G. Deposit date: 2021-08-18 Release date: 2022-11-09 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Crystal structure of the BCL6 BTB domain in complex with OICR-7859 To Be Published
6CQ1	BCL6 BTB domain in complex with 15a Descriptor: 2-{6-({[2-(1H-indol-3-yl)ethyl]carbamothioyl}amino)-3-[(4-methylpiperazin-1-yl)methyl]-1H-indol-1-yl}-N-(propan-2-yl)acetamide, B-cell lymphoma 6 protein Authors: Linhares, B.M, Cheng, H, Xue, F, Cierpicki, T. Deposit date: 2018-03-14 Release date: 2019-03-20 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.69921041 Å) Cite: Identification of Thiourea-Based Inhibitors of the B-Cell Lymphoma 6 BTB Domain via NMR-Based Fragment Screening and Computer-Aided Drug Design. J.Med.Chem., 61, 2018
6C3N	Crystal structure of BCL6 BTB domain in complex with compound 7CC5 Descriptor: B-cell lymphoma 6 protein, N-(2-phenylethyl)-N'-pyridin-3-ylthiourea Authors: Linhares, B, Cheng, H, Xue, F, Cierpicki, T. Deposit date: 2018-01-10 Release date: 2019-01-16 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.53170586 Å) Cite: Identification of Thiourea-Based Inhibitors of the B-Cell Lymphoma 6 BTB Domain via NMR-Based Fragment Screening and Computer-Aided Drug Design. J.Med.Chem., 61, 2018
6C3L	Crystal structure of BCL6 BTB domain with compound 15f Descriptor: B-cell lymphoma 6 protein, N-[2-(1H-indol-3-yl)ethyl]-N'-{3-[(4-methylpiperazin-1-yl)methyl]-1-[2-(morpholin-4-yl)-2-oxoethyl]-1H-indol-6-yl}thiourea Authors: Linhares, B, Cheng, H, Cierpicki, T, Xue, F. Deposit date: 2018-01-10 Release date: 2019-01-16 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.46092153 Å) Cite: Identification of Thiourea-Based Inhibitors of the B-Cell Lymphoma 6 BTB Domain via NMR-Based Fragment Screening and Computer-Aided Drug Design. J.Med.Chem., 61, 2018
5X4N	Crystal structure of the BCL6 BTB domain in complex with Compound 4 Descriptor: 1,2-ETHANEDIOL, 5-chloro-N4-phenylpyrimidine-2,4-diamine, B-cell lymphoma 6 protein Authors: Sogabe, S, Ida, K, Lane, W, Snell, G. Deposit date: 2017-02-13 Release date: 2017-05-24 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.94 Å) Cite: Discovery of a B-Cell Lymphoma 6 Protein-Protein Interaction Inhibitor by a Biophysics-Driven Fragment-Based Approach J. Med. Chem., 60, 2017
5X4O	Crystal structure of the BCL6 BTB domain in complex with Compound 5 Descriptor: B-cell lymphoma 6 protein, N-methyl-N-{3-[({2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl}amino)methyl]pyridin-2-yl}methanesulfonamide Authors: Sogabe, S, Ida, K, Lane, W, Snell, G. Deposit date: 2017-02-13 Release date: 2017-05-24 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Discovery of a B-Cell Lymphoma 6 Protein-Protein Interaction Inhibitor by a Biophysics-Driven Fragment-Based Approach J. Med. Chem., 60, 2017

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