8YW5
 
 | | Cryo-EM structure of the retatrutide-bound human GCGR-Gs complex | | Descriptor: | Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Li, W.Z, Zhou, Q.T, Cong, Z.T, Yuan, Q.N, Li, W.X, Zhao, F.H, Xu, H.E, Zhao, L.H, Yang, D.H, Wang, M.W. | | Deposit date: | 2024-03-29 | | Release date: | 2024-08-07 | | Method: | ELECTRON MICROSCOPY (2.84 Å) | | Cite: | Structural insights into the triple agonism at GLP-1R, GIPR and GCGR manifested by retatrutide.
Cell Discov, 10, 2024
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9FEF
 | | Cryo-EM structure of Trypanosoma cruzi (MDH)4-PEX5 complex | | Descriptor: | Peroxisome targeting signal 1 receptor, malate dehydrogenase | | Authors: | Lipinski, O, Sonani, R.R, Blat, A, Jemiola-Rzeminska, M, Patel, S.N, Sood, T, Dubin, G. | | Deposit date: | 2024-05-19 | | Release date: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (2.98 Å) | | Cite: | Cryo-EM structure of Trypanosoma cruzi (MDH)4-PEX5 complex
To Be Published
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8ZRK
 | | Cryo-EM structure of GPR119-Gs Complex with small molecule agonist GSK-1292263 | | Descriptor: | 5-[4-[[6-(4-methylsulfonylphenyl)pyridin-3-yl]oxymethyl]piperidin-1-yl]-3-propan-2-yl-1,2,4-oxadiazole, Glucose-dependent insulinotropic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Wong, T.S, Xiong, T.T, Zeng, Z.C, Gan, S.Y, Qiu, C, Du, Y. | | Deposit date: | 2024-06-04 | | Release date: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (2.82 Å) | | Cite: | Cryo-EM structure of GPR119-Gs complex
To be published
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9B6I
 | | Cryo-EM structure of the avian great tit TRPM8 channel in complex with the antagonist TC-I 2014 | | Descriptor: | 3-{7-(trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-benzimidazol-2-yl}-1-oxa-2-azaspiro[4.5]dec-2-ene, CALCIUM ION, CHOLESTEROL HEMISUCCINATE, ... | | Authors: | Yin, Y, Park, C.-G, Zhang, F, Fedor, J, Feng, S, Suo, Y, Im, W, Lee, S.-Y. | | Deposit date: | 2024-03-25 | | Release date: | 2024-08-21 | | Method: | ELECTRON MICROSCOPY (3.26 Å) | | Cite: | Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8.
Sci Adv, 10, 2024
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9BRD
 | | Synaptic Vesicle V-ATPase with synaptophysin and SidK, State 3 | | Descriptor: | (7R)-4,7-DIHYDROXY-N,N,N-TRIMETHYL-10-OXO-3,5,9-TRIOXA-4-PHOSPHAHEPTACOSAN-1-AMINIUM 4-OXIDE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Coupland, C.E, Rubinstein, J.L. | | Deposit date: | 2024-05-11 | | Release date: | 2024-06-26 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | High-resolution electron cryomicroscopy of V-ATPase in native synaptic vesicles.
Science, 385, 2024
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9IWQ
 | | Salmonella enterica serovar Typhimurium FliC(G426A)delta(204-292) forming the L-type straight filament | | Descriptor: | Flagellin | | Authors: | Waraich, K, Makino, F, Miyata, T, Kinoshita, M, Minamino, T, Namba, K. | | Deposit date: | 2024-07-25 | | Release date: | 2024-08-07 | | Method: | ELECTRON MICROSCOPY (2.08 Å) | | Cite: | Salmonella enterica serovar Typhimurium FliC(G426A)delta(204-292) forming the L-type straight filament
To Be Published
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9BHT
 | | Septin Hexameric Complex SEPT2/SEPT6/SEPT7 of Ciona intestinalis by Cryo-EM | | Descriptor: | CiSeptin-2, CiSeptin-6, CiSeptin-7, ... | | Authors: | Mendonca, D.C, Pereira, H.M, Garratt, R.C. | | Deposit date: | 2024-04-22 | | Release date: | 2024-07-10 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.26 Å) | | Cite: | Structural Insights into Ciona intestinalis Septins: Complexes Suggest a Mechanism for Nucleotide-dependent Interfacial Cross-talk.
J.Mol.Biol., 436, 2024
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9AXE
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9ASK
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8Y3U
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9FAC
 | | Additional cryo-EM structure of cardiac amyloid AL59 - mixed polymorph | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Monoclonal immunoglobulin light chains (LC) | | Authors: | Schulte, T, Speranzini, V, Chaves-Sanjuan, A, Milazzo, M, Ricagno, S. | | Deposit date: | 2024-05-10 | | Release date: | 2024-08-14 | | Last modified: | 2024-08-28 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Helical superstructures between amyloid and collagen in cardiac fibrils from a patient with AL amyloidosis.
Nat Commun, 15, 2024
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9IUY
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8Z0T
 | | Structure of the human ige-fc bound to its high affinity receptor fc(epsilon) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Du, S, Deng, M.J, Xiao, J.Y. | | Deposit date: | 2024-04-10 | | Release date: | 2024-07-10 | | Last modified: | 2024-09-11 | | Method: | ELECTRON MICROSCOPY (3.58 Å) | | Cite: | Structural insights into the high-affinity IgE receptor Fc epsilon RI complex.
Nature, 2024
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8YF7
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8Y84
 | | Structure of the high affinity receptor fc(epsilon)ri TM | | Descriptor: | CHOLESTEROL HEMISUCCINATE, High affinity immunoglobulin epsilon receptor subunit alpha, High affinity immunoglobulin epsilon receptor subunit beta, ... | | Authors: | Du, S, Deng, M.J, Xiao, J.Y. | | Deposit date: | 2024-02-05 | | Release date: | 2024-07-10 | | Last modified: | 2024-09-04 | | Method: | ELECTRON MICROSCOPY (2.98 Å) | | Cite: | Structural insights into the high-affinity IgE receptor Fc epsilon RI complex.
Nature, 2024
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9CVG
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9CHP
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8Y9B
 | | TcdB1 in complex with mini-binder | | Descriptor: | De novo design mini-binder, Toxin B, ZINC ION | | Authors: | Lv, X.C, Lu, P.L. | | Deposit date: | 2024-02-06 | | Release date: | 2024-08-28 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | TcdB1 in complex with mini-binder
To Be Published
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9FCH
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9C4C
 | | The structure of two MntR dimers bound to the native mnep promoter sequence | | Descriptor: | DNA (38-MER), DNA (39-MER), HTH-type transcriptional regulator MntR, ... | | Authors: | Shi, H, Fu, Y, Glasfeld, A, Ahuja, S. | | Deposit date: | 2024-06-04 | | Release date: | 2024-08-14 | | Method: | ELECTRON MICROSCOPY (3.09 Å) | | Cite: | The structure of two MntR dimers bound to the native mnep promoter sequence.
To Be Published
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9C9Y
 | | Human TOP3B-TDRD3 core complex in DNA pre-cleavage state | | Descriptor: | DNA (5'-D(P*AP*CP*TP*AP*AP*AP*AP*T)-3'), DNA topoisomerase 3-beta-1, MANGANESE (II) ION, ... | | Authors: | Yang, X, Chen, X, Yang, W, Pommier, Y. | | Deposit date: | 2024-06-16 | | Release date: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (3.35 Å) | | Cite: | Structural Insights into human Topoisomerase 3-beta DNA and RNA catalytic cycles and topo-gate dynamics
To Be Published
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9B8O
 | | Synaptic Vesicle V-ATPase with synaptophysin and SidK, State 3, Vo | | Descriptor: | (7R)-4,7-DIHYDROXY-N,N,N-TRIMETHYL-10-OXO-3,5,9-TRIOXA-4-PHOSPHAHEPTACOSAN-1-AMINIUM 4-OXIDE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Coupland, C.E, Rubinstein, J.L. | | Deposit date: | 2024-03-31 | | Release date: | 2024-06-26 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | High-resolution electron cryomicroscopy of V-ATPase in native synaptic vesicles.
Science, 385, 2024
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8YQQ
 | | Structure of HKU1B RBD with TMPRSS2 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, Transmembrane protease serine 2 | | Authors: | Gao, X, Cui, S, Ding, W, Zhu, K, Shang, K, Zhu, H. | | Deposit date: | 2024-03-19 | | Release date: | 2024-08-28 | | Method: | ELECTRON MICROSCOPY (3.95 Å) | | Cite: | Structural basis for the interaction between human coronavirus HKU1 spike receptor binding domain and its receptor TMPRSS2.
Cell Discov, 10, 2024
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9FOR
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9C0D
 | | E.Faecium GroEL | | Descriptor: | Chaperonin GroEL | | Authors: | Watson, E.R, Lander, G.C. | | Deposit date: | 2024-05-25 | | Release date: | 2024-08-07 | | Last modified: | 2024-08-14 | | Method: | ELECTRON MICROSCOPY (3.97 Å) | | Cite: | Bis-sulfonamido-2-phenylbenzoxazoles Validate the GroES/EL Chaperone System as a Viable Antibiotic Target.
J.Am.Chem.Soc., 146, 2024
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