PDB: 53102 resultsInfo pagesStatus searchChemie searchBIRD

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8UV0	Discovery of (4-Pyrazolyl)-2-Aminopyrimidines as Potent and Selective Inhibitors of Cyclin-Dependent Kinase 2 Descriptor: 1-{(4M)-4-[2-{[1-(cyclopropanesulfonyl)piperidin-4-yl]amino}-5-(trifluoromethyl)pyrimidin-4-yl]-1H-pyrazol-1-yl}-2-methylpropan-2-ol, Cyclin-dependent kinase 2 Authors: Deller, M.C, Epling, L.B. Deposit date: 2023-11-02 Release date: 2024-02-14 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Discovery of (4-Pyrazolyl)-2-aminopyrimidines as Potent and Selective Inhibitors of Cyclin-Dependent Kinase 2. J.Med.Chem., 67, 2024
8UD8	Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution Descriptor: (4S,5aS,8S,8aR)-4-(2-methylpropyl)-N-[(1R,5Z,7R,8R,9R,10R,11S,12R)-10,11,12-trihydroxy-7-methyl-13-oxa-2-thiabicyclo[7.3.1]tridec-5-en-8-yl]octahydro-2H-oxepino[2,3-c]pyrrole-8-carboxamide (non-preferred name), 16S Ribosomal RNA, 23S Ribosomal RNA, ... Authors: Aleksandrova, E.V, Syroegin, E.A, Wu, K.J.Y, Tresco, B.I.C, Ramkissoon, A, See, D.N.Y, Liow, P, Dittemore, G.A, Yu, M, Testolin, G, Mitcheltree, M.J, Liu, R.Y, Svetlov, M.S, Myers, A.G, Polikanov, Y.S. Deposit date: 2023-09-28 Release date: 2024-02-21 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.6 Å) Cite: An antibiotic preorganized for ribosomal binding overcomes antimicrobial resistance. Science, 383, 2024
8UM2	Carboxy terminus of Oleate Hydratase in phosphate buffer Descriptor: Myosin-cross-reactive antigen Authors: Grace, C.R, Radka, C. Deposit date: 2023-10-17 Release date: 2024-01-31 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: The carboxy terminus causes interfacial assembly of oleate hydratase on a membrane bilayer. J.Biol.Chem., 300, 2024
8XQS	Structure of human class T GPCR TAS2R14-DNGi complex with Flufenamic acid. Descriptor: 2-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO] BENZOIC ACID, CHOLESTEROL, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, ... Authors: Hu, X.L, Wu, L.J, Hua, T, Liu, Z.J. Deposit date: 2024-01-05 Release date: 2024-07-10 Last modified: 2024-07-24 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Bitter taste TAS2R14 activation by intracellular tastants and cholesterol. Nature, 631, 2024
8XQO	Structure of human class T GPCR TAS2R14-Gi complex with Aristolochic acid A. Descriptor: 8-methoxy-6-nitro-naphtho[1,2-e][1,3]benzodioxole-5-carboxylic acid, CHOLESTEROL, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, ... Authors: Hu, X.L, Wu, L.J, Hua, T, Liu, Z.J. Deposit date: 2024-01-05 Release date: 2024-07-10 Last modified: 2024-10-09 Method: ELECTRON MICROSCOPY (2.77 Å) Cite: Bitter taste TAS2R14 activation by intracellular tastants and cholesterol. Nature, 631, 2024
8XQT	Structure of human class T GPCR TAS2R14-Gi complex. Descriptor: CHOLESTEROL, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... Authors: Hu, X.L, Pei, Y, Wu, L.J, Hua, T, Liu, Z.J. Deposit date: 2024-01-05 Release date: 2024-07-10 Last modified: 2024-07-24 Method: ELECTRON MICROSCOPY (2.94 Å) Cite: Bitter taste TAS2R14 activation by intracellular tastants and cholesterol. Nature, 631, 2024
5VKV	Solution NMR structure of the membrane electron transporter CcdA Descriptor: Cytochrome c-type biogenesis protein CcdA Authors: Zhou, Y, Bushweller, J.H. Deposit date: 2017-04-24 Release date: 2018-01-31 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Solution structure and elevator mechanism of the membrane electron transporter CcdA. Nat. Struct. Mol. Biol., 25, 2018
8VL3	Solution NMR structure of de novo designed protein F3 parent Descriptor: De novo designed protein F3 parent Authors: McShan, A.C, Simma, M.K. Deposit date: 2024-01-11 Release date: 2024-08-07 Method: SOLUTION NMR Cite: Solution NMR structure of de novo designed protein F3 parent To Be Published
8VL4	Solution NMR Structure of de novo design protein 312 parent Descriptor: De novo design protein 312 parent Authors: McShan, A.C, Simma, M.K. Deposit date: 2024-01-11 Release date: 2024-08-07 Method: SOLUTION NMR Cite: Solution NMR Structure of de novo design protein 312 parent To Be Published
8UD6	Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution Descriptor: (4S,5aS,8S,8aR)-4-(2-methylpropyl)-N-[(1R,5Z,7R,8R,9R,10R,11S,12R)-10,11,12-trihydroxy-7-methyl-13-oxa-2-thiabicyclo[7.3.1]tridec-5-en-8-yl]octahydro-2H-oxepino[2,3-c]pyrrole-8-carboxamide (non-preferred name), 16S Ribosomal RNA, 23S Ribosomal RNA, ... Authors: Aleksandrova, E.V, Syroegin, E.A, Wu, K.J.Y, Tresco, B.I.C, Ramkissoon, A, See, D.N.Y, Liow, P, Dittemore, G.A, Yu, M, Testolin, G, Mitcheltree, M.J, Liu, R.Y, Svetlov, M.S, Myers, A.G, Polikanov, Y.S. Deposit date: 2023-09-28 Release date: 2024-02-21 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.7 Å) Cite: An antibiotic preorganized for ribosomal binding overcomes antimicrobial resistance. Science, 383, 2024
8UM1	Structure of the Carboxy terminus of Oleate Hydratase Descriptor: Myosin-cross-reactive antigen Authors: Grace, C.R, Radka, C. Deposit date: 2023-10-17 Release date: 2024-01-31 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: The carboxy terminus causes interfacial assembly of oleate hydratase on a membrane bilayer. J.Biol.Chem., 300, 2024
8UD7	Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution Descriptor: (4S,5aS,8S,8aR)-4-(2-methylpropyl)-N-[(1R,5Z,7R,8R,9R,10R,11S,12R)-10,11,12-trihydroxy-7-methyl-13-oxa-2-thiabicyclo[7.3.1]tridec-5-en-8-yl]octahydro-2H-oxepino[2,3-c]pyrrole-8-carboxamide (non-preferred name), 16S Ribosomal RNA, 23S Ribosomal RNA, ... Authors: Aleksandrova, E.V, Syroegin, E.A, Wu, K.J.Y, Tresco, B.I.C, Ramkissoon, A, See, D.N.Y, Liow, P, Dittemore, G.A, Yu, M, Testolin, G, Mitcheltree, M.J, Liu, R.Y, Svetlov, M.S, Myers, A.G, Polikanov, Y.S. Deposit date: 2023-09-28 Release date: 2024-02-21 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.55 Å) Cite: An antibiotic preorganized for ribosomal binding overcomes antimicrobial resistance. Science, 383, 2024
8XQN	Structure of human class T GPCR TAS2R14-DNGi complex with Aristolochic acid A. Descriptor: 8-methoxy-6-nitro-naphtho[1,2-e][1,3]benzodioxole-5-carboxylic acid, CHOLESTEROL, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, ... Authors: Hu, X.L, Wu, L.J, Hua, T, Liu, Z.J. Deposit date: 2024-01-05 Release date: 2024-07-10 Last modified: 2024-07-31 Method: ELECTRON MICROSCOPY (3.05 Å) Cite: Bitter taste TAS2R14 activation by intracellular tastants and cholesterol. Nature, 631, 2024
8UNP	CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class E) Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Papasergi-Scott, M.M, Skiniotis, G. Deposit date: 2023-10-19 Release date: 2024-03-06 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
8UNY	CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class N) Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Papasergi-Scott, M.M, Skiniotis, G. Deposit date: 2023-10-19 Release date: 2024-03-06 Last modified: 2024-06-05 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
8UO0	CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class P) Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Papasergi-Scott, M.M, Skiniotis, G. Deposit date: 2023-10-19 Release date: 2024-03-06 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
8UK4	Crystal structure of human polymerase eta with incoming dTMPnPP nucleotide opposite urea lesion Descriptor: 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*(UD8)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), ... Authors: Tomar, R, Egli, M, Stone, M.P. Deposit date: 2023-10-12 Release date: 2024-03-20 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (3.02 Å) Cite: Replication Bypass of the N -(2-Deoxy-d-erythro-pentofuranosyl)-urea DNA Lesion by Human DNA Polymerase eta. Biochemistry, 63, 2024
6GH0	Two-quartet kit* G-quadruplex is formed via double-stranded pre-folded structure Descriptor: DNA (5'-D(*GP*GP*CP*GP*AP*GP*GP*AP*GP*GP*GP*GP*CP*GP*TP*GP*GP*CP*CP*GP*GP*C)-3') Authors: Kotar, A, Rigo, R, Sissi, C, Plavec, J. Deposit date: 2018-05-04 Release date: 2019-01-09 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Two-quartet kit* G-quadruplex is formed via double-stranded pre-folded structure. Nucleic Acids Res., 47, 2019
8UNT	CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class I) Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Papasergi-Scott, M.M, Skiniotis, G. Deposit date: 2023-10-19 Release date: 2024-03-06 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
8UNS	CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class H) Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Papasergi-Scott, M.M, Skiniotis, G. Deposit date: 2023-10-19 Release date: 2024-03-06 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
8UO4	CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class T) Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Papasergi-Scott, M.M, Skiniotis, G. Deposit date: 2023-10-19 Release date: 2024-03-06 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (4 Å) Cite: Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
6C2U	Solution structure of a phosphate-loop protein Descriptor: phosphate-loop protein Authors: Yang, F, Yang, W, Lin, Y.R, Romero Romero, M.L, Tawfik, D, Baker, D, Varani, G. Deposit date: 2018-01-09 Release date: 2018-11-21 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Simple yet functional phosphate-loop proteins. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
8UNN	CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class C) Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Papasergi-Scott, M.M, Skiniotis, G. Deposit date: 2023-10-19 Release date: 2024-03-06 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
8UO3	CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class S) Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Papasergi-Scott, M.M, Skiniotis, G. Deposit date: 2023-10-19 Release date: 2024-03-06 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
8UJV	Crystal structure of human polymerase eta with incoming dCMPnPP nucleotide opposite urea lesion Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*(UD8)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), ... Authors: Tomar, R, Egli, M, Stone, M.P. Deposit date: 2023-10-11 Release date: 2024-03-20 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (2.23 Å) Cite: Replication Bypass of the N -(2-Deoxy-d-erythro-pentofuranosyl)-urea DNA Lesion by Human DNA Polymerase eta. Biochemistry, 63, 2024

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