1ZBF
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![BU of 1zbf by Molmil](/molmil-images/mine/1zbf) | Crystal structure of B. halodurans RNase H catalytic domain mutant D132N | Descriptor: | SULFATE ION, ribonuclease H-related protein | Authors: | Nowotny, M, Gaidamakov, S.A, Crouch, R.J, Yang, W. | Deposit date: | 2005-04-08 | Release date: | 2005-07-12 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Crystal Structures of RNase H Bound to an RNA/DNA Hybrid: Substrate Specificity and Metal-Dependent Catalysis. Cell(Cambridge,Mass.), 121, 2005
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1ZHW
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![BU of 1zhw by Molmil](/molmil-images/mine/1zhw) | Structure of yeast oxysterol binding protein Osh4 in complex with 20-hydroxycholesterol | Descriptor: | 20-HYDROXYCHOLESTEROL, KES1 protein, LEAD (II) ION | Authors: | Im, Y.J, Raychaudhuri, S, Prinz, W.A, Hurley, J.H. | Deposit date: | 2005-04-26 | Release date: | 2005-09-06 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural mechanism for sterol sensing and transport by OSBP-related proteins Nature, 437, 2005
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1ZI7
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![BU of 1zi7 by Molmil](/molmil-images/mine/1zi7) | Structure of truncated yeast oxysterol binding protein Osh4 | Descriptor: | KES1 protein, SULFATE ION | Authors: | Im, Y.J, Raychaudhuri, S, Prinz, W.A, Hurley, J.H. | Deposit date: | 2005-04-27 | Release date: | 2005-09-06 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural mechanism for sterol sensing and transport by OSBP-related proteins Nature, 437, 2005
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2F95
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![BU of 2f95 by Molmil](/molmil-images/mine/2f95) | M intermediate structure of sensory rhodopsin II/transducer complex in combination with the ground state structure | Descriptor: | RETINAL, Sensory rhodopsin II, Sensory rhodopsin II transducer, ... | Authors: | Moukhametzianov, R.I, Klare, J.P, Efremov, R.G, Baecken, C, Goeppner, A, Labahn, J, Engelhard, M, Bueldt, G, Gordeliy, V.I. | Deposit date: | 2005-12-05 | Release date: | 2006-03-07 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Development of the signal in sensory rhodopsin and its transfer to the cognate transducer. Nature, 440, 2006
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1ZHX
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![BU of 1zhx by Molmil](/molmil-images/mine/1zhx) | Structure of yeast oxysterol binding protein Osh4 in complex with 25-hydroxycholesterol | Descriptor: | 25-HYDROXYCHOLESTEROL, KES1 protein | Authors: | Im, Y.J, Raychaudhuri, S, Prinz, W.A, Hurley, J.H. | Deposit date: | 2005-04-26 | Release date: | 2005-09-06 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural mechanism for sterol sensing and transport by OSBP-related proteins Nature, 437, 2005
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1ZI9
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![BU of 1zi9 by Molmil](/molmil-images/mine/1zi9) | Crystal Structure Analysis of the dienelactone hydrolase (E36D, C123S) mutant- 1.5 A | Descriptor: | Carboxymethylenebutenolidase, GLYCEROL, SULFATE ION | Authors: | Kim, H.-K, Liu, J.-W, Carr, P.D, Ollis, D.L. | Deposit date: | 2005-04-27 | Release date: | 2005-07-05 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Following directed evolution with crystallography: structural changes observed in changing the substrate specificity of dienelactone hydrolase. Acta Crystallogr.,Sect.D, 61, 2005
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1ZJ4
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![BU of 1zj4 by Molmil](/molmil-images/mine/1zj4) | Crystal Structure Analysis of the dienelactone hydrolase mutant (E36D, C123S) bound with the PMS moiety of the protease inhibitor, Phenylmethylsulfonyl fluoride (PMSF)- 1.7 A | Descriptor: | Carboxymethylenebutenolidase, GLYCEROL, SULFATE ION | Authors: | Kim, H.-K, Liu, J.-W, Carr, P.D, Ollis, D.L. | Deposit date: | 2005-04-28 | Release date: | 2005-07-05 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Following directed evolution with crystallography: structural changes observed in changing the substrate specificity of dienelactone hydrolase. Acta Crystallogr.,Sect.D, 61, 2005
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2FCY
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![BU of 2fcy by Molmil](/molmil-images/mine/2fcy) | HIV-1 DIS kissing-loop in complex with Neomycin | Descriptor: | CHLORIDE ION, HIV-1 DIS RNA, NEOMYCIN, ... | Authors: | Ennifar, E, Paillart, J.C, Marquet, R, Dumas, P. | Deposit date: | 2005-12-13 | Release date: | 2006-05-16 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Targeting the dimerization initiation site of HIV-1 RNA with aminoglycosides: from crystal to cell. Nucleic Acids Res., 34, 2006
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4K2J
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![BU of 4k2j by Molmil](/molmil-images/mine/4k2j) | |
1ZML
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![BU of 1zml by Molmil](/molmil-images/mine/1zml) | Crystal Structure of the Catalytic Domain of Factor XI in complex with (R)-1-(4-(4-(hydroxymethyl)-1,3,2-dioxaborolan-2-yl)phenethyl)guanidine | Descriptor: | (R)-1-(4-(4-(HYDROXYMETHYL)-1,3,2-DIOXABOROLAN-2-YL)PHENETHYL)GUANIDINE, BICARBONATE ION, Coagulation factor XI, ... | Authors: | Lazarova, T.I, Jin, L, Rynkiewicz, M.J, Gorga, J.C, Bibbins, F, Meyers, H.V, Babine, R.E, Strickler, J.E. | Deposit date: | 2005-05-10 | Release date: | 2006-05-09 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Synthesis and in vitro biological evaluation of aryl boronic acids as potential inhibitors of factor XIa. Bioorg.Med.Chem.Lett., 16, 2006
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1Z38
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![BU of 1z38 by Molmil](/molmil-images/mine/1z38) | Crystal structure of Trichomonas vaginalis purine nucleoside phosphorylase complexed with inosine | Descriptor: | INOSINE, purine nucleoside phosphorylase | Authors: | Zhang, Y, Wang, W.H, Wu, S.W, Wang, C.C, Ealick, S.E. | Deposit date: | 2005-03-10 | Release date: | 2005-03-29 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Identification of a subversive substrate of Trichomonas vaginalis purine nucleoside phosphorylase and the crystal structure of the enzyme-substrate complex. J.Biol.Chem., 280, 2005
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1ZP6
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![BU of 1zp6 by Molmil](/molmil-images/mine/1zp6) | Crystal Structure of Atu3015, a Putative Cytidylate Kinase from Agrobacterium tumefaciens, Northeast Structural Genomics Target AtR62 | Descriptor: | SULFATE ION, hypothetical protein Atu3015 | Authors: | Forouhar, F, Abashidze, M, Vorobiev, S.M, Kuzin, A, Conover, K, Acton, T.B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2005-05-16 | Release date: | 2005-05-24 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Crystal Structure of Atu3015, a Putative Cytidylate Kinase from Agrobacterium tumefaciens, Northeast Structural Genomics Target AtR62 To be Published
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1ZPB
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![BU of 1zpb by Molmil](/molmil-images/mine/1zpb) | Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with 4-Methyl-pentanoic acid {1-[4-guanidino-1-(thiazole-2-carbonyl)-butylcarbamoyl]-2-methyl-propyl}-amide | Descriptor: | 4-METHYL-PENTANOIC ACID {1-[4-GUANIDINO-1-(THIAZOLE-2-CARBONYL)-BUTYLCARBAMOYL]-2-METHYL-PROPYL}-AMIDE, Coagulation factor XI, SULFATE ION | Authors: | Deng, H, Bannister, T.D, Jin, L, Nagafuji, P, Celatka, C.A, Lin, J, Lazarova, T.I, Rynkiewicz, M.J, Quinn, J, Bibbins, F, Pandey, P, Gorga, J, Babine, R.E, Meyers, H.V, Abdel-Meguid, S.S, Strickler, J.E. | Deposit date: | 2005-05-16 | Release date: | 2006-04-18 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Synthesis, SAR exploration, and X-ray crystal structures of factor XIa inhibitors containing an alpha-ketothiazole arginine Bioorg.Med.Chem.Lett., 16, 2006
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1ZA7
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![BU of 1za7 by Molmil](/molmil-images/mine/1za7) | The crystal structure of salt stable cowpea cholorotic mottle virus at 2.7 angstroms resolution. | Descriptor: | Coat protein | Authors: | Bothner, B, Speir, J.A, Qu, C, Willits, D.A, Young, M.J, Johnson, J.E. | Deposit date: | 2005-04-05 | Release date: | 2006-03-21 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Enhanced local symmetry interactions globally stabilize a mutant virus capsid that maintains infectivity and capsid dynamics. J.Virol., 80, 2006
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1ZBP
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![BU of 1zbp by Molmil](/molmil-images/mine/1zbp) | X-Ray Crystal Structure of Protein VPA1032 from Vibrio parahaemolyticus. Northeast Structural Genomics Consortium Target VpR44 | Descriptor: | hypothetical protein VPA1032 | Authors: | Forouhar, F, Yong, W, Vorobiev, S.M, Ciao, M, Acton, T.B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2005-04-08 | Release date: | 2005-04-19 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Functional insights from structural genomics. J.STRUCT.FUNCT.GENOM., 8, 2007
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1ZDL
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![BU of 1zdl by Molmil](/molmil-images/mine/1zdl) | Crystal Structure of Mouse Thioredoxin Reductase Type 2 | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Thioredoxin reductase 2, ... | Authors: | Biterova, E.I, Turanov, A.A, Gladyshev, V.N, Barycki, J.J. | Deposit date: | 2005-04-14 | Release date: | 2005-11-01 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structures of oxidized and reduced mitochondrial thioredoxin reductase provide molecular details of the reaction mechanism. Proc.Natl.Acad.Sci.Usa, 102, 2005
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1Z35
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![BU of 1z35 by Molmil](/molmil-images/mine/1z35) | Crystal structure of Trichomonas vaginalis purine nucleoside phosphorylase complexed with 2-fluoroadenosine | Descriptor: | 2-(6-AMINO-2-FLUORO-PURIN-9-YL)-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-3,4-DIOL, purine nucleoside phosphorylase | Authors: | Zhang, Y, Wang, W.H, Wu, S.W, Wang, C.C, Ealick, S.E. | Deposit date: | 2005-03-10 | Release date: | 2005-03-29 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Identification of a subversive substrate of Trichomonas vaginalis purine nucleoside phosphorylase and the crystal structure of the enzyme-substrate complex. J.Biol.Chem., 280, 2005
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1ZHR
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![BU of 1zhr by Molmil](/molmil-images/mine/1zhr) | Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with Benzamidine (S434A-T475A-C482S-K437A Mutant) | Descriptor: | BENZAMIDINE, coagulation factor XI | Authors: | Jin, L, Pandey, P, Babine, R.E, Weaver, D.T, Abdel-Meguid, S.S, Strickler, J.E. | Deposit date: | 2005-04-26 | Release date: | 2005-09-20 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Mutation of surface residues to promote crystallization of activated factor XI as a complex with benzamidine: an essential step for the iterative structure-based design of factor XI inhibitors. Acta Crystallogr.,Sect.D, 61, 2005
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1ZIX
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![BU of 1zix by Molmil](/molmil-images/mine/1zix) | Crystal Structure Analysis of the dienelactone hydrolase mutant (E36D, R105H, C123S, G211D, K234N)- 1.8 A | Descriptor: | Carboxymethylenebutenolidase, GLYCEROL | Authors: | Kim, H.-K, Liu, J.-W, Carr, P.D, Ollis, D.L. | Deposit date: | 2005-04-27 | Release date: | 2005-07-05 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Following directed evolution with crystallography: structural changes observed in changing the substrate specificity of dienelactone hydrolase. Acta Crystallogr.,Sect.D, 61, 2005
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2ACQ
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![BU of 2acq by Molmil](/molmil-images/mine/2acq) | AN ANION BINDING SITE IN HUMAN ALDOSE REDUCTASE: MECHANISTIC IMPLICATIONS FOR THE BINDING OF CITRATE, CACODYLATE, AND GLUCOSE-6-PHOSPHATE | Descriptor: | 6-O-phosphono-alpha-D-glucopyranose, ALDOSE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Harrison, D.H, Bohren, K.M, Gabbay, K.H, Petsko, G.A, Ringe, D. | Deposit date: | 1994-04-15 | Release date: | 1994-07-31 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | An anion binding site in human aldose reductase: mechanistic implications for the binding of citrate, cacodylate, and glucose 6-phosphate. Biochemistry, 33, 1994
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2DST
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![BU of 2dst by Molmil](/molmil-images/mine/2dst) | Crystal Structure Analysis of TT1977 | Descriptor: | Hypothetical protein TTHA1544 | Authors: | Xie, Y, Kishishita, S, Murayama, K, Shirouzu, M, Chen, L, Liu, Z.J, Wang, B.C, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2006-07-06 | Release date: | 2007-01-06 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of the minimized alpha/beta-hydrolase fold protein from Thermus thermophilus HB8. Acta Crystallogr.,Sect.F, 63, 2007
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2A1N
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![BU of 2a1n by Molmil](/molmil-images/mine/2a1n) | |
2A6E
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![BU of 2a6e by Molmil](/molmil-images/mine/2a6e) | Crystal structure of the T. Thermophilus RNA polymerase holoenzyme | Descriptor: | DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... | Authors: | Artsimovitch, I, Vassylyeva, M.N, Svetlov, D, Svetlov, V, Perederina, A, Igarashi, N, Matsugaki, N, Wakatsuki, S, Tahirov, T.H, Vassylyev, D.G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2005-07-02 | Release date: | 2005-09-20 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins. Cell(Cambridge,Mass.), 122, 2005
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2A7S
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![BU of 2a7s by Molmil](/molmil-images/mine/2a7s) | Crystal Structure of the Acyl-CoA Carboxylase, AccD5, from Mycobacterium tuberculosis | Descriptor: | Probable propionyl-CoA carboxylase beta chain 5 | Authors: | Lin, T, Melgar, M, Purdon, J, Tseng, T, Tsai, S.C. | Deposit date: | 2005-07-06 | Release date: | 2006-02-21 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structure-based inhibitor design of AccD5, an essential acyl-CoA carboxylase carboxyltransferase domain of Mycobacterium tuberculosis. Proc.Natl.Acad.Sci.Usa, 103, 2006
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2A8P
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![BU of 2a8p by Molmil](/molmil-images/mine/2a8p) | 2.7 Angstrom Crystal Structure of the Complex Between the Nuclear SnoRNA Decapping Nudix Hydrolase X29 and Manganese | Descriptor: | MANGANESE (II) ION, U8 snoRNA-binding protein X29 | Authors: | Scarsdale, J.N, Peculis, B.A, Wright, H.T. | Deposit date: | 2005-07-08 | Release date: | 2006-03-28 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structures of U8 snoRNA decapping nudix hydrolase, X29, and its metal and cap complexes Structure, 14, 2006
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