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1XB7
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X-ray structure of ERRalpha LBD in complex with a PGC-1alpha peptide at 2.5A resolution
Descriptor: IODIDE ION, Peroxisome proliferator activated receptor gamma coactivator 1 alpha, Steroid hormone receptor ERR1
Authors:Kallen, J, Schlaeppi, J.M, Bitsch, F, Filipuzzi, I, Schilb, A, Riou, V, Graham, A, Strauss, A, Geiser, M, Fournier, B.
Deposit date:2004-08-30
Release date:2004-09-14
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Evidence for Ligand-independent Transcriptional Activation of the Human Estrogen-related Receptor {alpha} (ERR{alpha}): CRYSTAL STRUCTURE OF ERR{alpha} LIGAND BINDING DOMAIN IN COMPLEX WITH PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR COACTIVATOR-1{alpha}
J.Biol.Chem., 279, 2004
3A1Q
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BU of 3a1q by Molmil
Crystal structure of the mouse RAP80 UIMs in complex with Lys63-linked di-ubiquitin
Descriptor: Ubiquitin, Ubiquitin interaction motif-containing protein 1
Authors:Sato, Y, Yoshikawa, A, Mimura, H, Yamashita, M, Yamagata, A, Fukai, S.
Deposit date:2009-04-21
Release date:2009-07-21
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by tandem UIMs of RAP80
Embo J., 28, 2009
1DXO
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BU of 1dxo by Molmil
Crystal structure of human NAD[P]H-QUINONE oxidoreductase CO with 2,3,5,6,tetramethyl-P-benzoquinone (duroquinone) at 2.5 Angstrom resolution
Descriptor: DUROQUINONE, FLAVIN-ADENINE DINUCLEOTIDE, QUINONE REDUCTASE
Authors:Faig, M, Bianchet, M.A, Chen, S, Winski, S, Ross, D, Amzel, L.M.
Deposit date:2000-01-12
Release date:2000-04-23
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of Recombinant Mouse and Human Nad(P)H:Quinone Oxidoreductases:Species Comparison and Structural Changes with Substrate Binding and Release
Proc.Natl.Acad.Sci.USA, 97, 2000
1DXQ
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CRYSTAL STRUCTURE OF MOUSE NAD[P]H-QUINONE OXIDOREDUCTASE
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, QUINONE REDUCTASE
Authors:Faig, M, Bianchet, M.A, Chen, S, Winski, S, Ross, D, Amzel, L.M.
Deposit date:2000-01-14
Release date:2000-04-17
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structures of Recombinant Mouse and Human Nad(P)H:Quinone Oxidoreductases:Species Comparison and Structural Changes with Substrate Binding and Release
Proc.Natl.Acad.Sci.USA, 97, 2000
1Z00
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BU of 1z00 by Molmil
Solution structure of the C-terminal domain of ERCC1 complexed with the C-terminal domain of XPF
Descriptor: DNA excision repair protein ERCC-1, DNA repair endonuclease XPF
Authors:Tripsianes, K, Folkers, G, Ab, E, Das, D, Odijk, H, Jaspers, N.G.J, Hoeijmakers, J.H.J, Kaptein, R, Boelens, R.
Deposit date:2005-03-01
Release date:2005-12-20
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:The Structure of the Human ERCC1/XPF Interaction Domains Reveals a Complementary Role for the Two Proteins in Nucleotide Excision Repair
Structure, 13, 2005
5T0J
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BU of 5t0j by Molmil
Structural basis for dynamic regulation of the human 26S proteasome
Descriptor: 26S protease regulatory subunit 10B, 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, ...
Authors:Chen, S, Wu, J, Lu, Y, Ma, Y.B, Lee, B.H, Yu, Z, Ouyang, Q, Finley, D, Kirschner, M.W, Mao, Y.
Deposit date:2016-08-16
Release date:2016-10-19
Last modified:2016-11-30
Method:ELECTRON MICROSCOPY (8 Å)
Cite:Structural basis for dynamic regulation of the human 26S proteasome.
Proc.Natl.Acad.Sci.USA, 113, 2016
3NR5
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BU of 3nr5 by Molmil
Crystal structure of human Maf1
Descriptor: Repressor of RNA polymerase III transcription MAF1 homolog
Authors:Ringel, R, Vannini, A, Kusser, A.G, Berninghausen, O, Kassavetis, G.A, Cramer, P.
Deposit date:2010-06-30
Release date:2010-10-13
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Molecular Basis of RNA Polymerase III Transcription Repression by Maf1
Cell(Cambridge,Mass.), 143, 2010
1U3Y
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BU of 1u3y by Molmil
Crystal structure of ILAC mutant of dimerisation domain of NF-kB p50 transcription factor
Descriptor: Nuclear factor NF-kappa-B p105 subunit
Authors:Chirgadze, D.Y, Demydchuk, M, Becker, M, Moran, S, Paoli, M.
Deposit date:2004-07-22
Release date:2004-08-17
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.901 Å)
Cite:Snapshot of Protein Structure Evolution Reveals Conservation of Functional Dimerization through Intertwined Folding
Structure, 12, 2004
1U42
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BU of 1u42 by Molmil
Crystal structure of MLAM mutant of dimerisation domain of NF-kB p50 transcription factor
Descriptor: Nuclear factor NF-kappa-B p105 subunit
Authors:Chirgadze, D.Y, Demydchuk, M, Becker, M, Moran, S, Paoli, M.
Deposit date:2004-07-23
Release date:2004-08-17
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.699 Å)
Cite:Snapshot of Protein Structure Evolution Reveals Conservation of Functional Dimerization through Intertwined Folding
Structure, 12, 2004
1ZAI
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BU of 1zai by Molmil
Fructose-1,6-bisphosphate Schiff base intermediate in FBP aldolase from rabbit muscle
Descriptor: 1,6-FRUCTOSE DIPHOSPHATE (LINEAR FORM), Fructose-bisphosphate aldolase A
Authors:St-Jean, M, Lafrance-Vanasse, J, Liotard, B, Sygusch, J.
Deposit date:2005-04-06
Release date:2005-05-10
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:High Resolution Reaction Intermediates of Rabbit Muscle Fructose-1,6-bisphosphate Aldolase: substrate cleavage and induced fit.
J.Biol.Chem., 280, 2005
2YPS
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BU of 2yps by Molmil
Crystal structure of the PX domain of human sorting nexin 3
Descriptor: SORTING NEXIN-3
Authors:Canning, P, Kiyani, W, Froese, D.S, Krojer, T, Strain-Damerell, C, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Yue, W.W.
Deposit date:2012-10-31
Release date:2013-03-20
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of the Px Domain of Human Sorting Nexin 3
To be Published
3ODS
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BU of 3ods by Molmil
Crystal structure of the K185A mutant of the N-terminal domain of human Symplekin
Descriptor: 1,2-ETHANEDIOL, Symplekin
Authors:Tong, L, Xiang, K.
Deposit date:2010-08-11
Release date:2010-10-06
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex.
Nature, 467, 2010
3M11
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BU of 3m11 by Molmil
Crystal Structure of Aurora A Kinase complexed with inhibitor
Descriptor: 1-(4-{2-[(5,6-diphenylfuro[2,3-d]pyrimidin-4-yl)amino]ethyl}phenyl)-3-phenylurea, Serine/threonine-protein kinase 6
Authors:Wu, J.S, Leou, J.S, Coumar, M.S, Hsieh, H.P, Wu, S.Y.
Deposit date:2010-03-03
Release date:2011-03-09
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Fast-forwarding hit to lead: aurora and epidermal growth factor receptor kinase inhibitor lead identification
J.Med.Chem., 53, 2010
5T1G
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BU of 5t1g by Molmil
chromo shadow domain of CBX1 in complex with a histone peptide
Descriptor: Chromobox protein homolog 1, Histone H3.1, UNKNOWN ATOM OR ION
Authors:Liu, Y, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2016-08-19
Release date:2016-09-14
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:chromo shadow domain of CBX1 in complex with a histone peptide
To Be Published
5T1I
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BU of 5t1i by Molmil
CBX3 chromo shadow domain in complex with histone H3 peptide
Descriptor: Chromobox protein homolog 3, Histone H3.1, UNKNOWN ATOM OR ION
Authors:Liu, Y, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2016-08-19
Release date:2016-09-14
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Peptide recognition by heterochromatin protein 1 (HP1) chromoshadow domains revisited: Plasticity in the pseudosymmetric histone binding site of human HP1.
J. Biol. Chem., 292, 2017
1FJC
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BU of 1fjc by Molmil
SOLUTION STRUCTURE OF NUCLEOLIN RBD2
Descriptor: NUCLEOLIN RBD2
Authors:Allain, F.H.-T, Gilbert, D.E, Bouvet, P, Feigon, J.
Deposit date:2000-08-07
Release date:2000-10-16
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Solution structure of the two N-terminal RNA-binding domains of nucleolin and NMR study of the interaction with its RNA target.
J.Mol.Biol., 303, 2000
5U2F
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BU of 5u2f by Molmil
BRD4 first bromodomain (BD1) in complex with dual PI3 kinase (PI3K) inhibitor SF2558HA
Descriptor: Bromodomain-containing protein 4, N-hydroxy-4-[5-(morpholin-4-yl)-7-oxo-7H-thieno[3,2-b]pyran-3-yl]benzamide
Authors:Andrews, F.H, Kutateladze, T.G.
Deposit date:2016-11-30
Release date:2017-02-08
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.525 Å)
Cite:Dual-activity PI3K-BRD4 inhibitor for the orthogonal inhibition of MYC to block tumor growth and metastasis.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
1U2V
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BU of 1u2v by Molmil
Crystal structure of Arp2/3 complex with bound ADP and calcium
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Actin-Related Protein 2, Actin-Related Protein 3, ...
Authors:Nolen, B.J, Littlefield, R.S, Pollard, T.D.
Deposit date:2004-07-20
Release date:2004-11-09
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Crystal structures of actin-related protein 2/3 complex with bound ATP or ADP
Proc.Natl.Acad.Sci.Usa, 101, 2004
1U3Z
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BU of 1u3z by Molmil
Crystal structure of MLAC mutant of dimerisation domain of NF-kB p50 transcription factor
Descriptor: Nuclear factor NF-kappa-B p105 subunit
Authors:Chirgadze, D.Y, Demydchuk, M, Becker, M, Moran, S, Paoli, M.
Deposit date:2004-07-23
Release date:2004-08-17
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Snapshot of Protein Structure Evolution Reveals Conservation of Functional Dimerization through Intertwined Folding
Structure, 12, 2004
3B0F
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BU of 3b0f by Molmil
Crystal structure of the UBA domain of p62 and its interaction with ubiquitin
Descriptor: SULFATE ION, Sequestosome-1
Authors:Isogai, S, Morimoto, D, Arita, K, Unzai, S, Tenno, T, Hasegawa, J, Sou, Y, Komatsu, M, Tanaka, K, Shirakawa, M, Tochio, H.
Deposit date:2011-06-09
Release date:2011-06-29
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structure of the ubiquitin-associated (UBA) domain of p62 and its interaction with ubiquitin.
J.Biol.Chem., 286, 2011
1FST
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BU of 1fst by Molmil
CRYSTAL STRUCTURE OF TRUNCATED HUMAN RHOGDI TRIPLE MUTANT
Descriptor: RHO GDP-DISSOCIATION INHIBITOR 1
Authors:Longenecker, K.L, Garrard, S.M, Sheffield, P.J, Derewenda, Z.S.
Deposit date:2000-09-11
Release date:2001-05-02
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Protein crystallization by rational mutagenesis of surface residues: Lys to Ala mutations promote crystallization of RhoGDI.
Acta Crystallogr.,Sect.D, 57, 2001
1FCX
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BU of 1fcx by Molmil
ISOTYPE SELECTIVITY OF THE HUMAN RETINOIC ACID NUCLEAR RECEPTOR HRAR: THE COMPLEX WITH THE RARGAMMA-SELECTIVE RETINOID BMS184394
Descriptor: 6-[HYDROXY-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTALEN-2-YL)-METHYL]-NAPHTALENE-2-CARBOXYLIC ACID, DODECYL-ALPHA-D-MALTOSIDE, RETINOIC ACID RECEPTOR GAMMA-1
Authors:Klaholz, B.P, Mitschler, A, Moras, D, Structural Proteomics in Europe (SPINE)
Deposit date:2000-07-19
Release date:2000-09-11
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Structural basis for isotype selectivity of the human retinoic acid nuclear receptor.
J.Mol.Biol., 302, 2000
1SJR
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BU of 1sjr by Molmil
NMR Structure of RRM2 from Human Polypyrimidine Tract Binding Protein Isoform 1 (PTB1)
Descriptor: Polypyrimidine tract-binding protein 1
Authors:Simpson, P.J, Monie, T.P, Szendroi, A, Davydova, N, Tyzack, J.K, Conte, M.R, Read, C.M, Cary, P.D, Svergun, D.I, Konarev, P.V, Petoukhov, M.V, Curry, S, Matthews, S.J.
Deposit date:2004-03-04
Release date:2004-09-14
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Structure and RNA Interactions of the N-Terminal RRM Domains of PTB
Structure, 12, 2004
2YLM
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BU of 2ylm by Molmil
Mechanism of USP7 (HAUSP) activation by its C-terminal ubiquitin-like domain (HUBL) and allosteric regulation by GMP-synthetase.
Descriptor: CHLORIDE ION, UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7
Authors:Faesen, A.C, Perrakis, A, Sixma, T.K.
Deposit date:2011-06-03
Release date:2011-10-19
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Mechanism of Usp7/Hausp Activation by its C- Terminal Ubiquitin-Like Domain and Allosteric Regulation by Gmp-Synthetase
Mol.Cell, 44, 2011
1W60
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BU of 1w60 by Molmil
NATIVE HUMAN PCNA
Descriptor: PROLIFERATING CELL NUCLEAR ANTIGEN
Authors:Kontopidis, G, Wu, S, Zheleva, D, Taylor, P, Mcinnes, C, Lane, D, Fischer, P, Walkinshaw, M.
Deposit date:2004-08-11
Release date:2005-01-13
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Structural and Biochemical Studies of Human Proliferating Cell Nuclear Antigen Complexes Provide a Rationale for Cyclin Association and Inhibitor Design
Proc.Natl.Acad.Sci.USA, 102, 2005

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